Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Lenalidomide (Revlimid) C13H13N3O3 259.26 TNF-α Rushworth S.A. (2013) Cellular Signalling 25 1 106-112


 1.00 110
LFM-A13   C11H8Br2N2O2 360.00 BTK Vassilev J.Biol.Chem. 274 1646
Mahajan et al J.Biol.Chem. 274 9587

100.00 113
LFM-A13   C11H8Br2N2O2 360.00 BTK Vassilev J.Biol.Chem. 274 1646
Mahajan et al J.Biol.Chem. 274 9587

10.00 108
LRRK2-IN1   C31H38N8O3 570.69 LRRK2 Deng X. (2011) Nat. Chem. Biol. 7 203

WO2010080712
 10.00 110
LRRK2-IN1   C31H38N8O3 570.69 LRRK2 Deng X. (2011) Nat. Chem. Biol. 7 203

WO2010080712
 1.00 114
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953
Li (2006) J.Med.Chem. 49 2138

10.00 109
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953
Li (2006) J.Med.Chem. 49 2138

1.00 111
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


 1.00 106
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


 0.10 102
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


 10.00 128