Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
LFM-A13   C11H8Br2N2O2 360.00 BTK Vassilev J.Biol.Chem. 274 1646
Mahajan et al J.Biol.Chem. 274 9587

10.00 101
LiCl   ClLi 42.39 GSK3b Galli C. (2013) Clin Oral Implants Res. 921-7.

WO2001074164
33
LiCl   ClLi 42.39 GSK3b Galli C. (2013) Clin Oral Implants Res. 921-7.

WO2001074164
64
LRRK2-IN1   C31H38N8O3 570.69 LRRK2 Deng X. (2011) Nat. Chem. Biol. 7 203

WO2010080712
10.00 67
LRRK2-IN1   C31H38N8O3 570.69 LRRK2 Deng X. (2011) Nat. Chem. Biol. 7 203

WO2010080712
1.00 96
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
5.00 95
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066
Cardone M.H. (1998) Science 282 1318
WO2013097266
10.00 90
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
0.10 102
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
1.00 67
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
0.01 92