Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

WO2007117466
 5.00 110
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

WO2007117466
 1.00 113
Chloroquine   C18H26ClN3 319.87 Anti Malarial

1.00 111
Chloroquine   C18H26ClN3 319.87 Anti Malarial

10.00 124
Crenolanib   C26H29N5O2 443.50 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24


 1.00 107
CZC-25146   C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology


10.00 93
CZC-25146   C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology


1.00 106
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 0.10 112
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 1.00 112
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

109