This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
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| Inhibitor | Brutto | MW | Action | Reference | Screen Conc | % Activity Remaining |
|---|---|---|---|---|---|---|
| Saracatinib (AZD0530) | C27H32ClN5O5 | 542.03 | Src |
H Laurent (2006) J. Med. Chem. 49(22) 6465-6488 |
0.10 | 114 |
| Saracatinib (AZD0530) | C27H32ClN5O5 | 542.03 | Src |
H Laurent (2006) J. Med. Chem. 49(22) 6465-6488 |
1.00 | 99 |
| SB-431542 | C22H16N4O3 · xH2O | 384.39 | ALK |
Inman et al (2002) Mol.Pharmacol. 62 65 |
10.00 | 92 |
| SB-431542 | C22H16N4O3 · xH2O | 384.39 | ALK |
Inman et al (2002) Mol.Pharmacol. 62 65 |
1.00 | 83 |
| SB-505124 | C20H21N3O2 · xHCl · yH2O | 335.40 | ALK |
Byfield (2004) Mol.Pharmacol. 65 744 |
0.10 | 101 |
| SB-505124 | C20H21N3O2 · xHCl · yH2O | 335.40 | ALK |
Byfield (2004) Mol.Pharmacol. 65 744 |
1.00 | 115 |
| SB-590885 | C27H27N5O2 | 453.54 | B-Raf |
King (2006) Cancer Res. 66 11100 |
0.10 | 95 |
| SB-590885 | C27H27N5O2 | 453.54 | B-Raf |
King (2006) Cancer Res. 66 11100 |
1.00 | 80 |
| SB-590885 | C27H27N5O2 | 453.54 | B-Raf |
King (2006) Cancer Res. 66 11100 |
10.00 | 100 |
| SB-747651A | C16H22N8O | 342.40 |
Naqvi (2012) Biochem. J. 441 (347–357) |
0.10 | 98 |