Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 243 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Structure Image Brutto MW Target Reference Reference 2
SGK1-Sanofi-14g C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78
SGK1-Sanofi-14h C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters , 6,73-78
SGK1-Sanofi-14n C17H12CIFN6O2S 418.83 SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78
SGK1-Sanofi-308-R C23H23FN6O4S 498.53 SGK1
SGK1-Sanofi-308-S C23H23FN6O4S 498.53 SGK1
SGK1-Sanofi-ex.290-R C24H25ClN6O5S 545.01 SGK1
SGK1-Sanofi-ex.290-S C24H25ClN6O5S 545.01 SGK1
SL-327 (MEK1-2 Inhibitor) C16H12F3N3S 335.4 MEK1, MEK2 Hetman M. (2002) J. Biol. Chem. 277 49577 Ohno M. (2001) Nat. Neurosci. 4 1238
SL0101-1 C25H24O12 516.46 RSK Smith (2005) Cancer Res. 65 1027 Goden Sayeski (2006) Am. J. Cell. Physiol. 291 1308
Sodium salicylate HOC6H4COONa 160.10 p38 Schwenger P. (1998) Mol Cell Biol. Jan 18(1) 78-84
Sodium valproate C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734 Kostrouchova (2007) Folia Biologica 53 37
SP600125 (JNK Inhibitor II, SAPK Inhibitor II) C14H8N2O 220.2 JNK Shin M. Boyd Y.D. (2002) Biochim. Biophys. Acta 1589 311 Bennett B.L. (2001) Proc. Natl. Acad. Sci. USA 98 13681
Sphingosine Kinase Inhibitor (SKI II) C15H11ClN2OS 339.2 SphK1 French (2003) Cancer Res. 63 5962. French (2006) J.Pharmacol.Exp.Ther. 318 596
SRC Inhibitor 1 C22H19N3O3 373.4 Src Tian G. (2001) Biochemistry 40 7084
SRT 1720 C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716
Staurosporine C28H26N4O3 466.54 Broad spectrum Boix J. (1997) Neuropharmacology 36 811-821 Wiesner D.A. and Dawson G. (1996) J. Neurochem. 66 1418-1425
STO 609 C19H10N2O3 • CH3CO2H 374.4 CaMKK Levine Y. (2007) J. Biol. Chem. 282 20351 Tokumitsu H. (2003) J. Biol. Chem. 278 10908
STOCK1S-50699 C29H31IN2S2 598.60 WNK Mori T. (2013) Biochem J. 1 455(3) 339-45
STOCK2S-26016 C20H19N3O2 333.38976 WNK Mori T. (2013) Biochem J. 1 455(3) 339-45
SU-5416 (VEGFR2 Kinase Inhibitor III) C15H14N2O 238.3 VEGF-R Tille J.C. (2003) Exp. Cell Res. 285 286 Itokawa T. (2002) Mol. Cancer Ther. 1 295
SU-6656 C19H21N3O3S 371.5 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319 Blake R.A. (2000) Mol. Cell. Biol. 20 9018
SU-6668 C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.
Sulfasalazine C18H14N4O5S 398.39 glutathione-S-transferase Liptay S. (1999) Br. J. Pharmacol. 128 1361 Volin M.V. (1999) Arthritis Rheum. 42 1927
Sunitinib (SU-11248) C22H27FN4O2 398.47 RTK Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39
SYK Inhibitor I C18H15N3O3S 353.4 SYK Lai J.Y. (2003) Bioorg. Med. Chem. Lett. 13 3111
SYK Inhibitor II C14H15F3N6O • 2HCl•2H2O 449.3 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936
SYK Inhibitor III C9H7NO4 193.2 SYK Wang W.Y. (2006) Mol. Pharmacol. 70 1380
SYK Inhibitor IV (BAY 61-3606) C20H18N6O3 • HCl • H2O 444.9 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869 Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275
Tenovin-6 C25H34N4O2S 454.6
TG003 C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254
Torin1 C35H28F3N5O2 607.62 mTOR Liu Q. (2012) J Biol Chem. 287 9742-52
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.
Ubiquitin E1 Inhibitor (PYR-41) C17H13N3O7 • 3H2O 425.4 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472
UCN-01 C28H26N4O4 482.5 PKC Reinhardt H.C. (2007) Cancer Cell 11 175 Jiang X. (2004) Mol. Cancer Ther. 3 1221
Uo126 C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623 Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839
Volasertib C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102 Grinshtein N (2011) Cancer Res 71(4) 1385-1395
VPS34-IN1 C21H24ClN7O 425.91 Vps34 Bago R (2014) Biochem J.
VPS34-IN2 (PIK-III) C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology
VX-680 C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262
VX-745 C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105
Withaferin A C28H38O6 470.6 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253
WNK-463 C21H24F3N7O2 463.46 WNK Yamada K (2016) Nat Chem Biol. 12(11) 896-898
Wortmannin (KY 12420) C23H24O8 428.4 PI3K Cross M.J. (1995) J. Biol. Chem. 270 25352 Nakamura I. (1995) FEBS Lett. 361 79
WP1130 C19H18BrN3O 384.26972 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085. V Kapuria (2010) Cancer Res 70(22) 9265-9276
Wyeth PDK1 Inhibitor Compound 1 C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549
Y-27632 C14H21N3O • 2HCl • H2O 338.3 ROCK Watanabe K. (2007) Nature Biotech. 25 681 Chitaley K. (2001) Nat. Med. 7 119
Zearalenone C18H22O5 318.4 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42
ZM 336372 C23H23N3O3 389.4 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559

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