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Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 243 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Structure Image Brutto MW Target Reference Reference 2
(5Z)-7-Oxozeaenol C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485 Windheim et al (2007) Biochem.J. 404 179
1 NA-PP1 (PP1 Analog) C19H19N5 317.4 Src Bishop A. C. (2000) Nature 407 395 Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
1 NM-PP1 (PP1 Analog II) C20H21N5 331.4 Src Ira G. (2004) Nature 431 1011 Papa F.R. (2003) Science 302 1533
2-Aminopurine C5H5N5 135.1267 PKR
A-443654 C24H23ON5x2HCl 470.39 Akt1 Shi Y. (2005) Neoplasia 7 992-1000.
A-769662 C20H12N2O3S 360.39 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416
A-83-01 C25H19N5S 421.52 ALK5 Tojo (2005) Cancer.Sci. 96 791
AG1296 (Tyrphostin) C16H14N2O2 266.29 PDGF Kovalenko M. (1994) Cancer Res. 54 6106
AG1478 (Tyrphostin) C16H14ClN3O2 315.75 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047
AG490 C17H14N2O3 294.3 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247 Eriksen K.W. (2001) Leukemia 15 787
AG879 (Tyrphostin) C18H24N2OS 316.5 Tyrosine-kinases Konrad R.J. (1996) J. Biol. Chem. 271 24179 Levitzki A. Gazit A. (1995) Science 267 1782
Akt Inhibitor IV C31H27IN4S 614.6 Akt Kau T. R. (2003) Cancer Cell 4 463
Akti 1/2 C34H29N7O 551.6 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27 Barnett S.F. (2005) Biochem. J. 385 399
Alsterpaullone C16H11N3O3 293.3 GSK3b, CDK5/p25, CDK1/cyclin B Leost M. (2000) Eur. J. Biochem. 267 5983 Schultz C. (1999) J. Med. Chem. 42 2909
Amgen TBK 1 inhibitor (Compound II) C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470
Amgen-NIK-28 C20H20N4O 332.4 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244
Amlexanox C16H14N2O4 298.293 TBK1, IKKe
ARA014418 C12H12N4O4S 308.3 GSK3 Noble W. (2005) Proc. Natl. Acad. Sci. USA 102 6990 Bhat R. (2003) J. Biol. Chem. 278 45937
AS601245 (JNK Inhibitor V) C20H16N6S 372.5 JNK Gaillard P. (2005) J. Med. Chem. 48 4596 Carboni S. (2005) J. Neurochem. 92 1054
AX 20017 C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804
AZD8055 C25H31N5O4 465.5 mTOR C1, mTOR C2 Chresta C.M. (2010) Cancer Res. 70 288-298 Sini P. (2010) Autophagy 6(4)
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181
Bay 65-1942 C22H26ClN3O4 431.91 IKKb Ziegelbauer K. (2005) British Journal of Pharmacology 145 178-192 (compound A) Moss N.C. (2007) Am J Physiol Heart Circ Physiol 293 H2248-53
BAY-11-7082 C10H9NO2S 207.2 NFKBIA Kamthong P.J. (2001) Biochem. J. 356 Izban K.F. (2000) Hum. Pathol. 31 1482
BAY439006 (Sorafenib, Nexavar) C21H16ClF3N4O3 464.8 Raf Lyons J.F. (2001) Endocrine Related Cancer 8 3 219-225 Wilhelm S.M. (2004) Cancer Res. 64(19) 7099-109
BI 2536 C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322
BI-78D3 C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813
BI-D-1870 C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38
BI605906 (BIX02514) C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104
BIO (6-Bromoindirubin-3'-oxime) C16H10BrN3O2 356.2 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957 Polychronopoulos P. (2004) J. Med. Chem. 47 935
BIRB-0796 (Doramapimod) C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008
Blebbistatin C18H16N2O2 292.3 myosin II Shu S. (2005) Proc. Natl. Acad. Sci. USA 102 1472 Kovacs M. (2004) J. Biol. Chem. 279 35557
BML-258 (SK1-I) C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391
BMS345541 (IKK Inhibitor III) C14H17N5 255.32 IKBKB Du Z. (2012) J Interferon Cytokine Res. 368-77
Bosutinib C26H29Cl2N5O3 530.45 src Vultur A. Mol Cancer Ther. (2008) 1185-94
BX-320 C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874
BX-517 C15H14N4O2 282.3 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818
BX-517 Analog (compound 7b) C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825
BX-795 C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874
BX-912 C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74
Caffeine C8H10N4O2 194.19 ATM Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150
CAY10576 C22H19N3O5S2 469.5 IKKe
CCT250862 NEK
Celastrol C29H38O4 450.6 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13
CGP-57380 C11H9FN6 244.23 MNK Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511 Proud C.G. (2005) Immunity 23 177-189
CGP-57380 analog (SHN-093) C12H11FN6 258.25 MNK Proud C.G. (2005) Immunity 23 177-189
CGP-57380 analog (SHN-095) C13H14N6 254.29 MNK
Chelerythrine Chloride C21H18NO4Cl 383.8 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209 Jarvis W.D. (1994) Cancer Res. 54 1707
CHIR 99021 (CT 99021) C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588
Chloroquine C18H26ClN3 319.87214 Anti Malarial

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