Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 243 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Structure Image Brutto MW Target Reference Reference 2
CKI-7 C11H12ClN3O2S • 2HCl 358.67 CK1 Rena G. (2004) EMBO Rep. 5 60-65
Compound C (Dorsomorphin) C24H25N5O 399.5 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33 Kim E.K. (2004) J. Biol. Chem. 279 19970
Cot-Tpl2 Inhibitor Compound 10b (Abbott) C20H15N3OS 345.42 Cot-Tpl2 Cusack K. (2009) Bioorganic and MedicinalChemistry Letters 19 1722-1725
Cot-Tpl2 Inhibitor Compound 38 (Abbott) C21H12F3N5OS 439.41 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 4952-4955
Cot-Tpl2 Inhibitor Compound 41 (Abbott) C21H14N6O2S 414.44 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 4952-4955
CP-690550 (Tasocitinib) C16H20N6O 312.38 JAK Manshouri T. (2008) Cancer Sci. 99(6) 1265-73
Crenolanib C26H29N5O2 443.5 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24
Curcumin C21H20O6 368.4 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488 Salvioli S. (2007) eCAM 4 181
CZC-25146 C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology
D 4476 C23H18N4O3 398.41 CK1 Liverton N.J. (1999) J. Med. Chem 42 2180-2190
Dasatinib C22H26ClN7O2S 487 BCR-ABL, Src Kantarjian H. N Engl J Med. (2010) 2260-70
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26 Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37
EGCG (Epigallocatechin Gallate) C22H18O11 458.4 PKC Dell'Aica I. (2004) EMBO Rep. 5 418-422 Tachibana H. (2004) Nat. Struct. Mol. Biol. 11 380
EMD638683 C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8
ER-27319 C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544
ETP 46464 C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727
Febuxostat (TMX-67, Adenuric, Uloric) C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36 Grabowski B (2010) Br J Clin Pharmacol. 70 57-64
FMK (Caspase Inhibitor I) C22H30FN3O7 467.5 Caspase Martin U. (2007) Apoptosis 12 525 Misaghi S. (2004) Chem. Biol. 11 1677
Fostamatinib C23H26FN6O9P 580.46
GDC-0941 C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32
Genentech LRRK2 inhibitor compound 18 (GNE-7915) C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33
Genentech LRRK2 inhibitor compound 19 C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33
Genistein C15H10O5 270.2 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109 Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124
GF 109203X (Go 6850) C25H24N4O2 412.5 PKC Hers I. (1999) FEBS Lett. 460 433 Ku W.-C. (1997) Biochem. Biophys. Res. Commun. 241 730
Gleevec (Imatinib) C29H31N7O 493.6 BCR-ABL Druker B. J. (2000) J. Clin. Invest. 105 3-7
Gö 6976 C24H18N4O 378.4 PKC Gschwendt M. (1996) FEBS Lett. 392 77 Wenzel-Seifert K. (1994) Biochem. Biophys. Res. Commun. 200 1536
Gö 7874 C27H26N4O4 • HCl 507 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55
GSK2334470 C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69
GSK2578215A C24H18FN3O2 399.42 LRRK2 Reith A. (2012) Bioorg. Med. Chem. Lett.
GSK2606414 C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207
GSK269962A C29H30N8O5 570.61 ROCK Doe C. (2007) J Pharmacol Exp Ther 320 89-98
GSK429286 C21H16F4N4O2 432.37 ROCK Goodman K. (2007) J. Med. Chem. 50 (1), 6-9 Nichols (2009) Biochem.J. 424 47
GSK461364 C27H28F3N5O2S 543.6 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92 K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7
GSK650394A C25H22N2O2 382.45 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483
GW441756 hydrochloride C17H13N3O • HCl 311.77 Trk A Wood E.R. (2004) Bioorg. Med. Chem. Lett. 14 953-957
GW501516 C21H18F3NO3S2 453.5 PPARd Sznaidman M.L. (2003) Bioorg Med Chem Lett 13(9) 1517-21
GW5074 (Raf1 Kinase Inhibitor I) C15H8Br2INO2 520.9 cRAF1 Lackey K. (2000) Bioorg. Med. Chem. Lett. 10 223
GW843682X (GSK-PLK1 Compound 2) C22H18F3N3O4S 477.46 PLK1 Emmitte K.A. (2009) Bioorganic and Medicinal Chemistry Letters 19 1018-1021
H-1152 (Rho Kinase Inhibitor) C16H21N3O2S • 2HCl 392.3 ROCK Ikenoya M. (2002) J. Neurochem. 81 9 Sasaki Y. (2002) Pharmacol. Ther. 93 225
H-7, Dihydrochloride C14H17N3O2S • 2HCl 364.3 serine/threonine kinases Ku W.C. (1997) Biochem. Biophys. Res. Commun. 241 730 Jarvis W.D. (1994) Cancer Res. 54 1707
H-8, Dihydrochloride C12H15N3O2S • 2HCl 338.3 serine/threonine kinases Ido M. (1991) Br. J. Cancer 64 1103 Hagiwara M. (1987) Mol. Pharmacol. 31 523
H-89, Dihydrochloride C20H20BrN3O2S • 2HCl 519.3 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000 Davies S.P. (2000) Biochem. J. 351 95
HA-1077, Dihydrochloride (Fasudil) C14H17N3O2S • 2HCl 364.3 PKA Watanabe K. (2007) Nature Biotechnology 25 681 Swärd K. (2000) J. Physiol. 522 33
HA-1100 (Hydroxyfasudil) C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842
Harmaline C13H14N2O 214.263 serotonin, monoamine oxidase Herraiz T. (2013) Drug Test. 1002/dta.1530.
Harmalol C12H12N2O • HCl • 2H2O 272.73 serotonin, monoamine oxidase Riba J. (2012) Drug Test. 610-6.
Harmane C12H10N2 182.22 serotonin, monoamine oxidase Smith KL. (2013) J Psychopharmacol. 162-70
Harmine C13H12N2O 212.25 serotonin, monoamine oxidase Song Y. (2004) Biochem. Biophys. Res. Commun. 317 128–132
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.
HG-9-91-01 C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91

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