Inhibitor | Dimethyl fumarate  

Screen Conc:

Kinase	% Activity Remaining	Standard Deviation
ABL	95	6
AMPK	109	2
AMPK (hum)	102	15
ASK1	105	0
Aurora A	114	14
Aurora B	98	11
BRK	110	2
BRSK1	91	3
BRSK2	108	15
BTK	135	7
CAMK1	99	3
CAMKK beta	93	9
CDK2-Cyclin A	87	15
CDK9-Cyclin T1	103	8
CHK1	97	18
CHK2	100	2
CK1 delta	105	7
CK1 gamma 2	101	3
CK2	91	2
CLK2	101	8
CSK	86	3
DAPK1	104	5
DDR2	99	23
DYRK1A	113	2
DYRK2	103	2
DYRK3	106	8
EF2K	111	10
EIF2AK3	102	20
EPH-A2	129	12
EPH-A4	119	0
EPH-B1	104	15
EPH-B2	120	7
EPH-B3	114	12
EPH-B4	136	26
ERK1	100	14
ERK2	105	11
ERK5	97	8
ERK8	96	8
FGF-R1	109	30
GCK	114	33
GSK3 beta	108	18
HER4	108	6
HIPK1	117	31
HIPK2	94	2
HIPK3	86	11
IGF-1R	117	5
IKK beta	85	8
IKK epsilon	93	0
IR	79	6
IRAK1	97	4
IRAK4	117	7
IRR	112	7
JAK2	116	1
JNK1	109	12
JNK2	101	13
JNK3	100	17
Lck	84	2
LKB1	100	1
MAP4K3	85	18
MAP4K5	91	20
MAPKAP-K2	93	9
MAPKAP-K3	106	24
MARK1	108	16
MARK2	111	25
MARK3	132	9
MARK4	96	12
MEKK1	112	27
MELK	107	26
MINK1	129	36
MKK1	118	15
MKK2	106	21
MKK6	103	26
MLK1	135	13
MLK3	105	20
MNK1	105	11
MNK2	110	14
MPSK1	109	11
MSK1	113	22
MST2	97	24
MST3	112	6
MST4	101	23
NEK2a	102	5
NEK6	124	39
NUAK1	101	16
OSR1	116	8
p38 alpha MAPK	106	14
p38 beta MAPK	104	6
p38 delta MAPK	110	20
p38 gamma MAPK	104	5
PAK2	86	7
PAK4	95	2
PAK5	93	11
PAK6	103	11
PDGFRA	104	15
PDK1	111	0
PHK	84	20
PIM1	101	2
PIM2	116	7
PIM3	92	8
PKA	99	15
PKB alpha	103	5
PKB beta	106	6
PKC alpha	105	18
PKC gamma	114	6
PKC zeta	118	24
PKD1	112	14
PLK1	91	6
PRAK	94	14
PRK2	84	6
RIPK2	111	9
ROCK 2	98	19
RSK1	90	9
RSK2	117	4
S6K1	115	9
SGK1	100	11
SIK2	103	9
SIK3	110	9
SmMLCK	102	1
Src	103	14
SRPK1	103	11
STK33	102	2
SYK	116	5
TAK1	103	0
TAO1	123	17
TBK1	106	28
TESK1	109	4
TGFBR1	95	11
TIE2	99	13
TLK1	110	1
TrkA	83	11
TSSK1	80	17
TTBK1	109	27
TTBK2	96	7
TTK	93	11
ULK1	103	17
ULK2	109	9
VEGFR1	98	2
WNK1	114	6
YES1	118	10
ZAP70	112	2

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	98	3
AMPK	106	8
AMPK (hum)	87	5
ASK1	93	8
Aurora A	117	3
Aurora B	90	11
BRK	102	1
BRSK1	100	30
BRSK2	91	11
BTK	88	37
CAMK1	88	9
CAMKK beta	92	21
CDK2-Cyclin A	77	8
CDK9-Cyclin T1	91	1
CHK1	101	20
CHK2	90	2
CK1 delta	88	1
CK1 gamma 2	92	1
CK2	98	13
CLK2	92	9
CSK	87	5
DAPK1	99	11
DDR2	103	1
DYRK1A	105	7
DYRK2	91	17
DYRK3	105	5
EF2K	99	21
EIF2AK3	95	6
EPH-A2	106	17
EPH-A4	98	4
EPH-B1	101	7
EPH-B2	118	10
EPH-B3	97	13
EPH-B4	115	24
ERK1	95	10
ERK2	85	10
ERK5	88	0
ERK8	89	1
FGF-R1	85	7
GCK	92	21
GSK3 beta	92	13
HER4	110	18
HIPK1	87	22
HIPK2	98	0
HIPK3	81	9
IGF-1R	93	26
IKK beta	84	3
IKK epsilon	80	4
IR	60	5
IRAK1	101	3
IRAK4	88	13
IRR	103	9
JAK2	100	11
JNK1	99	14
JNK2	90	9
JNK3	103	4
Lck	74	2
LKB1	93	19
MAP4K3	92	1
MAP4K5	91	8
MAPKAP-K2	92	3
MAPKAP-K3	87	1
MARK1	98	3
MARK2	91	4
MARK3	105	24
MARK4	76	21
MEKK1	90	24
MELK	93	0
MINK1	95	29
MKK1	96	20
MKK2	105	5
MKK6	92	3
MLK1	87	18
MLK3	100	14
MNK1	101	6
MNK2	101	1
MPSK1	114	9
MSK1	107	13
MST2	88	23
MST3	106	23
MST4	95	17
NEK2a	100	6
NEK6	103	19
NUAK1	97	15
OSR1	96	2
p38 alpha MAPK	90	11
p38 beta MAPK	111	4
p38 delta MAPK	92	13
p38 gamma MAPK	87	9
PAK2	101	1
PAK4	76	5
PAK5	87	9
PAK6	90	0
PDGFRA	101	8
PDK1	94	21
PHK	82	23
PIM1	99	2
PIM2	117	12
PIM3	96	17
PKA	92	14
PKB alpha	93	17
PKB beta	81	4
PKC alpha	99	7
PKC gamma	106	1
PKC zeta	89	1
PKD1	92	25
PLK1	94	15
PRAK	96	0
PRK2	83	31
RIPK2	93	17
ROCK 2	81	18
RSK1	91	11
RSK2	90	27
S6K1	99	13
SGK1	93	8
SIK2	82	14
SIK3	98	6
SmMLCK	79	24
Src	120	22
SRPK1	91	5
STK33	93	5
SYK	106	16
TAK1	105	11
TAO1	91	2
TBK1	89	14
TESK1	84	2
TGFBR1	93	4
TIE2	92	7
TLK1	103	8
TrkA	88	13
TSSK1	73	11
TTBK1	88	3
TTBK2	96	0
TTK	98	14
ULK1	97	9
ULK2	106	2
VEGFR1	108	2
WNK1	109	11
YES1	114	13
ZAP70	116	8

Screen Conc: 100.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	105	9
AMPK	104	13
AMPK (hum)	95	17
ASK1	88	7
Aurora A	120	7
Aurora B	102	8
BRK	112	11
BRSK1	93	18
BRSK2	99	16
BTK	113	23
CAMK1	96	1
CAMKK beta	101	13
CDK2-Cyclin A	75	2
CDK9-Cyclin T1	98	13
CHK1	93	9
CHK2	98	6
CK1 delta	94	3
CK1 gamma 2	101	9
CK2	95	5
CLK2	100	8
CSK	82	8
DAPK1	102	5
DDR2	100	2
DYRK1A	109	5
DYRK2	94	6
DYRK3	117	23
EF2K	106	6
EIF2AK3	107	8
EPH-A2	124	5
EPH-A4	105	9
EPH-B1	103	6
EPH-B2	118	6
EPH-B3	105	5
EPH-B4	122	10
ERK1	99	1
ERK2	88	27
ERK5	94	0
ERK8	100	5
FGF-R1	101	21
GCK	107	14
GSK3 beta	96	21
HER4	123	34
HIPK1	95	17
HIPK2	101	6
HIPK3	94	6
IGF-1R	92	5
IKK beta	91	5
IKK epsilon	96	11
IR	62	14
IRAK1	100	1
IRAK4	104	8
IRR	108	10
JAK2	105	5
JNK1	92	5
JNK2	94	8
JNK3	103	0
Lck	72	3
LKB1	97	15
MAP4K3	81	7
MAP4K5	87	7
MAPKAP-K2	86	1
MAPKAP-K3	97	4
MARK1	115	1
MARK2	108	7
MARK3	108	16
MARK4	92	7
MEKK1	95	13
MELK	103	14
MINK1	113	24
MKK1	109	3
MKK2	101	13
MKK6	88	10
MLK1	112	10
MLK3	97	2
MNK1	103	12
MNK2	107	7
MPSK1	116	6
MSK1	105	7
MST2	95	25
MST3	104	12
MST4	106	12
NEK2a	100	3
NEK6	110	22
NUAK1	104	3
OSR1	107	1
p38 alpha MAPK	99	13
p38 beta MAPK	112	20
p38 delta MAPK	102	18
p38 gamma MAPK	96	10
PAK2	104	9
PAK4	88	19
PAK5	125	6
PAK6	98	4
PDGFRA	103	0
PDK1	107	10
PHK	87	30
PIM1	107	5
PIM2	109	9
PIM3	106	1
PKA	96	19
PKB alpha	94	7
PKB beta	93	6
PKC alpha	101	2
PKC gamma	113	14
PKC zeta	103	17
PKD1	108	11
PLK1	100	3
PRAK	92	5
PRK2	108	9
RIPK2	104	12
ROCK 2	89	17
RSK1	92	1
RSK2	103	21
S6K1	101	10
SGK1	96	0
SIK2	94	17
SIK3	109	27
SmMLCK	99	5
Src	104	5
SRPK1	101	15
STK33	99	4
SYK	118	17
TAK1	115	1
TAO1	109	18
TBK1	100	8
TESK1	89	4
TGFBR1	101	24
TIE2	100	9
TLK1	117	1
TrkA	96	2
TSSK1	85	7
TTBK1	101	3
TTBK2	99	13
TTK	93	11
ULK1	99	18
ULK2	109	5
VEGFR1	110	3
WNK1	104	19
YES1	116	19
ZAP70	116	17