Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Cot-Tpl2 Inhibitor Compound 41 (Abbott) | C21H14N6O2S | 414.44 | Cot-Tpl2 | George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495… |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 77 | 0 |
ASK1 | 104 | 1 |
Aurora A | 103 | 9 |
Aurora B | 84 | 7 |
BRSK1 | 110 | 5 |
BRSK2 | 92 | 6 |
BTK | 95 | 8 |
CAMK1 | 105 | 8 |
CAMKK beta | 84 | 8 |
CDK2-Cyclin A | 91 | 1 |
CHK1 | 79 | 4 |
CHK2 | 97 | 8 |
CK1 delta | 90 | 2 |
CK2 | 30 | 3 |
CLK2 | 80 | 3 |
CSK | 86 | 12 |
DAPK1 | 88 | 6 |
DYRK1A | 21 | 8 |
DYRK2 |
7
|
0 |
DYRK3 | 15 | 1 |
EF2K | 100 | 12 |
EPH-A2 | 94 | 8 |
EPH-A4 | 103 | 5 |
EPH-B1 | 95 | 10 |
EPH-B2 | 106 | 6 |
EPH-B3 | 93 | 3 |
EPH-B4 | 97 | 0 |
ERK1 | 97 | 5 |
ERK2 | 96 | 11 |
ERK8 | 85 | 5 |
FGF-R1 | 105 | 0 |
GCK | 78 | 5 |
GSK3 beta | 38 | 2 |
HER4 | 88 | 11 |
HIPK1 | 104 | 5 |
HIPK2 | 64 | 5 |
HIPK3 | 96 | 3 |
IGF-1R | 107 | 15 |
IKK beta | 94 | 0 |
IKK epsilon | 89 | 0 |
IR | 111 | 10 |
IRAK4 | 88 | 6 |
IRR | 79 | 0 |
JAK2 | 97 | 4 |
JNK1 | 93 | 5 |
JNK2 | 99 | 10 |
JNK3 | 105 | 4 |
Lck | 113 | 7 |
LKB1 | 80 | 0 |
MAPKAP-K2 | 93 | 1 |
MAPKAP-K3 | 82 | 4 |
MARK1 | 89 | 1 |
MARK2 | 80 | 2 |
MARK3 | 94 | 5 |
MARK4 | 86 | 0 |
MEKK1 | 99 | 4 |
MELK | 77 | 10 |
MINK1 | 84 | 5 |
MKK1 | 85 | 12 |
MKK2 | 81 | 2 |
MKK6 | 104 | 6 |
MLK1 | 95 | 10 |
MLK3 | 81 | 5 |
MNK1 | 100 | 1 |
MNK2 | 94 | 0 |
MSK1 | 90 | 9 |
MST2 | 98 | 4 |
MST4 | 93 | 2 |
NEK2a | 94 | 5 |
NEK6 | 98 | 10 |
NUAK1 | 92 | 7 |
p38 alpha MAPK | 106 | 2 |
p38 beta MAPK | 97 | 3 |
p38 delta MAPK | 92 | 5 |
p38 gamma MAPK | 86 | 8 |
PAK2 | 93 | 1 |
PAK4 | 89 | 11 |
PAK5 | 81 | 2 |
PAK6 | 89 | 2 |
PDK1 | 79 | 7 |
PHK | 100 | 6 |
PIM1 | 70 | 7 |
PIM2 | 85 | 11 |
PIM3 | 79 | 0 |
PKA | 108 | 1 |
PKB alpha | 96 | 3 |
PKB beta | 77 | 14 |
PKC alpha | 76 | 6 |
PKC zeta | 100 | 2 |
PKD1 | 89 | 2 |
PLK1 | 90 | 1 |
PRAK | 104 | 4 |
PRK2 | 80 | 10 |
RIPK2 | 94 | 6 |
ROCK 2 | 73 | 5 |
RSK1 | 88 | 1 |
RSK2 | 77 | 2 |
S6K1 | 96 | 8 |
SGK1 | 100 | 5 |
SmMLCK | 86 | 11 |
Src | 85 | 2 |
SRPK1 | 99 | 7 |
SYK | 107 | 5 |
TAK1 | 82 | 5 |
TAO1 | 82 | 2 |
TBK1 | 87 | 2 |
TrkA | 83 | 6 |
TTK | 79 | 1 |
VEGFR1 | 84 | 14 |
YES1 | 91 | 10 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 49 | 4 |
ASK1 | 112 | 1 |
Aurora A | 78 | 1 |
Aurora B | 58 | 2 |
BRSK1 | 90 | 8 |
BRSK2 | 95 | 3 |
BTK | 71 | 7 |
CAMK1 | 85 | 6 |
CAMKK beta | 23 | 2 |
CDK2-Cyclin A | 105 | 2 |
CHK1 | 87 | 2 |
CHK2 | 59 | 0 |
CK1 delta | 59 | 5 |
CK2 |
6
|
1 |
CLK2 | 12 | 1 |
CSK | 100 | 4 |
DAPK1 | 18 | 2 |
DYRK1A |
3
|
1 |
DYRK2 |
2
|
0 |
DYRK3 |
6
|
2 |
EF2K | 101 | 9 |
EPH-A2 | 89 | 4 |
EPH-A4 | 112 | 9 |
EPH-B1 | 107 | 6 |
EPH-B2 | 99 | 8 |
EPH-B3 | 96 | 12 |
EPH-B4 | 96 | 3 |
ERK1 | 78 | 1 |
ERK2 | 96 | 15 |
ERK8 |
2
|
0 |
FGF-R1 | 61 | 6 |
GCK | 13 | 1 |
GSK3 beta |
10
|
2 |
HER4 | 73 | 4 |
HIPK1 |
9
|
2 |
HIPK2 |
10
|
10 |
HIPK3 |
10
|
0 |
IGF-1R | 95 | 11 |
IKK beta | 64 | 1 |
IKK epsilon | 69 | 2 |
IR | 108 | 4 |
IRAK4 | 74 | 2 |
IRR | 26 | 6 |
JAK2 | 74 | 0 |
JNK1 | 77 | 9 |
JNK2 | 85 | 3 |
JNK3 | 72 | 6 |
Lck | 99 | 8 |
LKB1 | 59 | 4 |
MAPKAP-K2 | 85 | 1 |
MAPKAP-K3 | 87 | 0 |
MARK1 | 78 | 1 |
MARK2 | 83 | 7 |
MARK3 | 71 | 6 |
MARK4 | 78 | 3 |
MEKK1 | 51 | 7 |
MELK | 62 | 1 |
MINK1 | 21 | 2 |
MKK1 | 78 | 7 |
MKK2 | 75 | 2 |
MKK6 | 99 | 9 |
MLK1 | 42 | 1 |
MLK3 | 25 | 0 |
MNK1 | 84 | 6 |
MNK2 | 58 | 6 |
MSK1 | 20 | 1 |
MST2 | 75 | 0 |
MST4 | 61 | 6 |
NEK2a | 80 | 9 |
NEK6 | 94 | 6 |
NUAK1 | 78 | 1 |
p38 alpha MAPK | 98 | 11 |
p38 beta MAPK | 104 | 6 |
p38 delta MAPK | 54 | 6 |
p38 gamma MAPK | 65 | 7 |
PAK2 | 90 | 7 |
PAK4 | 54 | 3 |
PAK5 | 66 | 6 |
PAK6 | 87 | 3 |
PDK1 | 91 | 12 |
PHK | 84 | 1 |
PIM1 | 18 | 5 |
PIM2 | 14 | 0 |
PIM3 | 21 | 4 |
PKA | 72 | 1 |
PKB alpha | 78 | 1 |
PKB beta | 62 | 2 |
PKC alpha | 30 | 1 |
PKC zeta | 67 | 5 |
PKD1 | 80 | 6 |
PLK1 | 24 | 3 |
PRAK | 56 | 1 |
PRK2 | 53 | 15 |
RIPK2 | 22 | 1 |
ROCK 2 | 38 | 0 |
RSK1 | 33 | 7 |
RSK2 | 44 | 5 |
S6K1 | 64 | 13 |
SGK1 | 68 | 2 |
SmMLCK | 35 | 5 |
Src | 92 | 2 |
SRPK1 | 48 | 6 |
SYK | 95 | 3 |
TAK1 | 75 | 11 |
TAO1 | 36 | 0 |
TBK1 | 63 | 11 |
TrkA | 89 | 6 |
TTK | 51 | 5 |
VEGFR1 | 24 | 6 |
YES1 | 87 | 1 |