Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
CZC-25146 | C22H25FN6O4S | 488.54 | LRRK2 | Ramsden N. (2011) ASC Chemical Biology |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 104 | 3 |
AMPK | 80 | 18 |
ASK1 | 121 | 1 |
Aurora A | 70 | 4 |
Aurora B | 58 | 2 |
BRK | 62 | 20 |
BRSK1 | 88 | 1 |
BRSK2 | 69 | 10 |
BTK | 89 | 1 |
CAMK1 | 90 | 0 |
CAMKK beta |
10
|
1 |
CDK2-Cyclin A | 123 | 39 |
CDK9-Cyclin T1 | 95 | 2 |
CHK1 | 96 | 8 |
CHK2 |
7
|
1 |
CK1 delta | 104 | 1 |
CK1 gamma 2 | 104 | 1 |
CK2 | 99 | 3 |
CLK2 | 71 | 8 |
CSK | 102 | 4 |
DAPK1 | 50 | 10 |
DDR2 | 76 | 4 |
DYRK1A | 93 | 13 |
DYRK2 | 56 | 1 |
DYRK3 | 86 | 0 |
EF2K | 112 | 2 |
EIF2AK3 | 85 | 7 |
EPH-A2 | 119 | 11 |
EPH-A4 | 110 | 6 |
EPH-B1 | 100 | 7 |
EPH-B2 | 111 | 25 |
EPH-B3 | 108 | 9 |
EPH-B4 | 128 | 1 |
ERK1 | 97 | 20 |
ERK2 | 127 | 17 |
ERK8 | 61 | 2 |
FGF-R1 | 87 | 0 |
GCK | 72 | 2 |
GSK3 beta | 91 | 8 |
HER4 | 59 | 6 |
HIPK1 | 94 | 14 |
HIPK2 | 87 | 6 |
HIPK3 | 100 | 9 |
IGF-1R | 47 | 2 |
IKK beta | 108 | 1 |
IKK epsilon | 118 | 19 |
IR | 52 | 11 |
IRAK1 | 87 | 3 |
IRAK4 | 73 | 3 |
IRR | 82 | 1 |
JAK2 | 75 | 12 |
JNK1 | 21 | 5 |
JNK2 | 25 | 7 |
JNK3 | 23 | 5 |
Lck | 101 | 9 |
LKB1 | 90 | 5 |
MAPKAP-K2 | 96 | 6 |
MAPKAP-K3 | 68 | 7 |
MARK1 | 100 | 11 |
MARK2 | 76 | 1 |
MARK3 | 49 | 11 |
MARK4 | 92 | 13 |
MEKK1 | 110 | 11 |
MELK | 91 | 6 |
MINK1 | 107 | 1 |
MKK1 | 109 | 6 |
MKK2 | 112 | 10 |
MKK6 | 84 | 1 |
MLK1 | 16 | 5 |
MLK3 | 22 | 4 |
MNK1 | 79 | 0 |
MNK2 | 92 | 27 |
MPSK1 | 112 | 10 |
MSK1 | 97 | 4 |
MST2 | 105 | 30 |
MST3 | 109 | 12 |
MST4 | 122 | 36 |
NEK2a | 97 | 2 |
NEK6 | 117 | 8 |
NUAK1 | 53 | 1 |
OSR1 | 94 | 10 |
p38 alpha MAPK | 108 | 6 |
p38 beta MAPK | 109 | 4 |
p38 delta MAPK | 97 | 11 |
p38 gamma MAPK | 99 | 3 |
PAK2 | 106 | 8 |
PAK4 | 42 | 3 |
PAK5 | 89 | 19 |
PAK6 | 101 | 10 |
PDK1 | 92 | 0 |
PHK | 26 | 0 |
PIM1 | 113 | 1 |
PIM2 | 107 | 12 |
PIM3 | 107 | 3 |
PKA | 97 | 4 |
PKB alpha | 107 | 14 |
PKB beta | 94 | 0 |
PKC alpha | 110 | 6 |
PKC gamma | 118 | 0 |
PKC zeta | 110 | 6 |
PKD1 | 94 | 1 |
PLK1 | 83 | 46 |
PRAK | 100 | 0 |
PRK2 | 74 | 4 |
RIPK2 | 82 | 3 |
ROCK 2 | 117 | 16 |
RSK1 | 54 | 0 |
RSK2 | 79 | 2 |
S6K1 | 98 | 5 |
SGK1 | 114 | 1 |
SIK2 | 68 | 11 |
SIK3 | 97 | 7 |
SmMLCK | 64 | 2 |
Src | 87 | 4 |
SRPK1 | 101 | 10 |
STK33 | 31 | 6 |
SYK | 101 | 1 |
TAK1 | 111 | 18 |
TAO1 | 87 | 8 |
TBK1 | 102 | 4 |
TESK1 | 98 | 1 |
TIE2 | 84 | 8 |
TLK1 | 103 | 14 |
TrkA | 106 | 14 |
TSSK1 | 35 | 1 |
TTBK1 | 106 | 6 |
TTK | 81 | 1 |
VEGFR1 | 11 | 2 |
WNK1 | 113 | 10 |
YES1 | 83 | 6 |
ZAP70 | 100 | 7 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 74 | 12 |
AMPK | 36 | 4 |
ASK1 | 105 | 5 |
Aurora A |
9
|
1 |
Aurora B |
8
|
1 |
BRK | 60 | 72 |
BRSK1 | 27 | 0 |
BRSK2 | 18 | 5 |
BTK | 41 | 6 |
CAMK1 | 80 | 15 |
CAMKK beta |
8
|
1 |
CDK2-Cyclin A | 101 | 1 |
CDK9-Cyclin T1 | 76 | 5 |
CHK1 | 32 | 6 |
CHK2 |
4
|
0 |
CK1 delta | 87 | 3 |
CK1 gamma 2 | 94 | 10 |
CK2 | 51 | 8 |
CLK2 | 67 | 65 |
CSK | 67 | 5 |
DAPK1 | 11 | 2 |
DDR2 | 31 | 7 |
DYRK1A | 73 | 2 |
DYRK2 | 16 | 2 |
DYRK3 | 39 | 5 |
EF2K | 94 | 8 |
EIF2AK3 | 42 | 11 |
EPH-A2 | 102 | 6 |
EPH-A4 | 94 | 17 |
EPH-B1 | 79 | 3 |
EPH-B2 | 95 | 4 |
EPH-B3 | 93 | 5 |
EPH-B4 | 95 | 7 |
ERK1 | 80 | 2 |
ERK2 | 106 | 2 |
ERK8 | 17 | 0 |
FGF-R1 | 30 | 2 |
GCK | 34 | 2 |
GSK3 beta | 90 | 23 |
HER4 | 14 | 1 |
HIPK1 | 123 | 2 |
HIPK2 | 34 | 4 |
HIPK3 | 61 | 7 |
IGF-1R |
8
|
5 |
IKK beta | 90 | 20 |
IKK epsilon | 57 | 1 |
IR | 27 | 4 |
IRAK1 | 34 | 7 |
IRAK4 | 16 | 0 |
IRR | 41 | 7 |
JAK2 | 22 | 0 |
JNK1 |
2
|
0 |
JNK2 |
7
|
4 |
JNK3 | 13 | 1 |
Lck | 82 | 24 |
LKB1 | 82 | 3 |
MAPKAP-K2 | 89 | 1 |
MAPKAP-K3 | 58 | 6 |
MARK1 | 23 | 17 |
MARK2 | 40 | 3 |
MARK3 | 14 | 4 |
MARK4 | 44 | 2 |
MEKK1 | 87 | 6 |
MELK | 44 | 4 |
MINK1 | 83 | 5 |
MKK1 | 81 | 3 |
MKK2 | 78 | 1 |
MKK6 | 45 | 3 |
MLK1 |
8
|
0 |
MLK3 | 11 | 0 |
MNK1 | 45 | 3 |
MNK2 | 46 | 27 |
MPSK1 | 100 | 8 |
MSK1 | 75 | 7 |
MST2 | 46 | 25 |
MST3 | 98 | 3 |
MST4 | 109 | 20 |
NEK2a | 58 | 4 |
NEK6 | 89 | 18 |
NUAK1 | 20 | 11 |
OSR1 | 73 | 0 |
p38 alpha MAPK | 85 | 13 |
p38 beta MAPK | 104 | 7 |
p38 delta MAPK | 88 | 15 |
p38 gamma MAPK | 93 | 9 |
PAK2 | 101 | 12 |
PAK4 |
9
|
6 |
PAK5 | 38 | 6 |
PAK6 | 80 | 16 |
PDK1 | 60 | 1 |
PHK |
8
|
0 |
PIM1 | 96 | 3 |
PIM2 | 94 | 12 |
PIM3 | 76 | 4 |
PKA | 82 | 1 |
PKB alpha | 98 | 9 |
PKB beta | 80 | 12 |
PKC alpha | 97 | 4 |
PKC gamma | 76 | 8 |
PKC zeta | 99 | 1 |
PKD1 | 41 | 3 |
PLK1 | 20 | 12 |
PRAK | 90 | 24 |
PRK2 | 33 | 8 |
RIPK2 | 48 | 14 |
ROCK 2 | 93 | 10 |
RSK1 | 12 | 0 |
RSK2 | 39 | 4 |
S6K1 | 35 | 2 |
SGK1 | 98 | 5 |
SIK2 | 17 | 1 |
SIK3 | 58 | 14 |
SmMLCK | 18 | 3 |
Src | 52 | 3 |
SRPK1 | 67 | 4 |
STK33 | 20 | 3 |
SYK | 38 | 3 |
TAK1 | 69 | 11 |
TAO1 | 48 | 3 |
TBK1 | 54 | 1 |
TESK1 | 68 | 19 |
TIE2 | 36 | 11 |
TLK1 | 93 | 4 |
TrkA | 57 | 19 |
TSSK1 |
9
|
2 |
TTBK1 | 93 | 4 |
TTK | 36 | 3 |
VEGFR1 |
6
|
4 |
WNK1 | 92 | 4 |
YES1 | 22 | 9 |
ZAP70 | 44 | 0 |