Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Febuxostat (TMX-67, Adenuric, Uloric)   C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36
Grabowski B (2010) Br J Clin Pharmacol. 70 57-64

10.00 87
Fostamatinib   C23H26FN6O9P 580.46

1.00 96
Fostamatinib   C23H26FN6O9P 580.46

0.10 106
Fostamatinib   C23H26FN6O9P 580.46

10.00 74
GDC-0941   C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32

WO2007129161
1.00 79
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


1.00 52
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


10.00 32
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


1.00 56
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


10.00 31
Genistein   C15H10O5 270.20 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109
Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124
WO1999045920
25.00 78