Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
CZC-25146   C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology


1.00 103
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 0.10 96
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 1.00 124
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

110
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

10.00 103
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

100.00 117
EMD638683   C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8

US2011060050
 10.00 109
EMD638683   C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8

US2011060050
 1.00 105
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727


 10.00 101
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727


 1.00 84