441

Compound name
Neratinib
Alt Name
HKI-272
Nerlynx
Compound Image
Neratinib.png
SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
MW
557.00
Brutto
C30H29ClN6O3
InChI
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChI Key
JWNPDZNEKVCWMY-VQHVLOKHSA-N
Approval Jurisdiction
2017 FDA 2018 EMA
Approved for clinical use
HER2-Positive Breast Cancer
CAS
698387-09-6
PubChem CID
9915743
Action
EGFR
Approved Drug List
1
Commercial Vendor
Wyeth-Pfizer-Puma