421

Compound name
Afatinib
Compound Image
Afatinib.png
SMILES
CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
MW
485.90
Brutto
C24H25ClFN5O3
InChI
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChI Key
ULXXDDBFHOBEHA-CWDCEQMOSA-N
Approval Jurisdiction
2013 FDA 2013 EMA
Approved for clinical use
NSCLC With EGFR Mutations
CAS
850140-72-6
PubChem CID
10184653
Action
EGFR
Approved Drug List
1
Commercial Vendor
Boehringer Ingelheim