189

Compound name
Ruxolitinib
Alt Name
Jakafi
Jakavi
INCB18424
Compound Image
Ruxolitinib.png
SMILES
C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
MW
306.37
Brutto
C17H18N6
InChI
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChI Key
HFNKQEVNSGCOJV-OAHLLOKOSA-N
Approval Jurisdiction
2011 FDA, 2012 EMA
Approved for clinical use
Myelofibrosis
CAS
941678-49-5
PubChem CID
25126798
Action
JAKs
Approved Drug List
1
Patent
<a href="http://www.wipo.int/patentscope/search/en/result.jsf?query=ALLNUM%3AWO2008157208">WO2008157208</a>
Commercial Vendor
Incyte Novartis