Inhibitor | Akti 1/2  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Akti 1/2   C34H29N7O 551.60 612847-09-3 10196499 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27 Barnett S.F. (2005) Biochem. J. 385 399

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
YES1 86 4
TBK1 103 11
SYK 83 2
SRPK1 87 1
Src 97 3
SmMLCK 86 7
SGK1 106 5
S6K1 98 1
RSK2 85 7
RSK1 94 4
ROCK 2 92 7
PRK2 78 1
PRAK 93 5
PLK1 83 2
PKD1 90 4
PKC zeta 101 0
PKC alpha 101 5
PKB beta 101 6
PKB alpha 85 3
PKA 90 8
PIM3 97 5
PIM2 95 6
PIM1 83 12
PHK 104 1
PDK1 91 9
PAK6 112 8
PAK5 87 7
PAK4 99 4
p38 gamma MAPK 110 7
p38 delta MAPK 104 5
p38 beta MAPK 103 10
p38 alpha MAPK 111 5
NEK7 86 0
NEK6 83 1
NEK2a 92 6
MST4 92 1
MST2 103 0
MSK1 84 2
MNK2 93 11
MNK1 81 0
MKK1 75 2
MELK 86 10
MARK3 86 1
MAPKAP-K3 76 3
MAPKAP-K2 84 6
Lck 81 4
JNK3 79 3
JNK2 95 0
JNK1 85 0
IRR 91 3
IKK epsilon 107 7
IKK beta 91 11
HIPK3 72 2
HIPK2 98 6
GSK3 beta 83 3
FGF-R1 89 8
ERK8 80 5
ERK2 71 15
ERK1 95 3
EPH-A2 95 6
EF2K 107 11
DYRK3 87 6
DYRK2 105 3
DYRK1A 97 11
CSK 97 11
CK2 85 1
CK1 delta 106 7
CHK2 83 7
CHK1 97 0
CDK2-Cyclin A 92 3
CAMK1 90 3
BRSK2 93 0
Aurora C 83 0
Aurora B 83 5
AMPK 96 14
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
YES1 88 8
TBK1 106 10
SYK 84 10
SRPK1 84 9
Src 118 1
SmMLCK 11 4
SGK1 82 3
S6K1 71 6
RSK2 74 1
RSK1 67 1
ROCK 2 91 1
PRK2 67 10
PRAK 79 5
PLK1 89 2
PKD1 82 14
PKC zeta 96 9
PKC alpha 87 8
PKB beta 87 14
PKB alpha 64 8
PKA 76 5
PIM3 59 6
PIM2 89 3
PIM1 56 6
PHK 101 9
PDK1 94 7
PAK6 92 1
PAK5 60 3
PAK4 48 4
p38 gamma MAPK 93 9
p38 delta MAPK 98 11
p38 beta MAPK 113 3
p38 alpha MAPK 98 13
NEK7 84 10
NEK6 75 3
NEK2a 99 3
MST4 80 4
MST2 78 2
MSK1 93 14
MNK2 79 3
MNK1 84 1
MKK1 76 10
MELK 67 0
MARK3 95 12
MAPKAP-K3 71 5
MAPKAP-K2 59 1
Lck 64 6
JNK3 80 7
JNK2 81 12
JNK1 70 9
IRR 81 13
IKK epsilon 67 6
IKK beta 89 2
HIPK3 65 2
HIPK2 84 3
GSK3 beta 77 9
FGF-R1 75 3
ERK8 70 1
ERK2 75 14
ERK1 99 5
EPH-A2 84 7
EF2K 40 6
DYRK3 74 1
DYRK2 118 1
DYRK1A 93 12
CSK 103 15
CK2 91 14
CK1 delta 110 2
CHK2 82 7
CHK1 85 2
CDK2-Cyclin A 97 13
CAMKK beta 108 9
CAMKK alpha 62 3
CAMK1
3
 0
BRSK2 92 12
Aurora C 65 0
Aurora B 60 3
AMPK 92 10
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
YES1 79 6
VEGFR1 71 3
TTK 92 3
TrkA 76 7
TBK1 88 4
TAO1 87 4
TAK1 78 8
SYK 89 7
SRPK1 84 7
Src 105 9
SmMLCK 82 13
SGK1 98 4
S6K1 106 8
RSK2 74 1
RSK1 97 4
ROCK 2 82 10
RIPK2 57 3
PRK2 79 7
PRAK 92 5
PLK1 98 4
PKD1 86 7
PKC zeta 113 4
PKC alpha 82 3
PKB beta 65 7
PKB alpha 95 4
PKA 100 10
PIM3 63 1
PIM2 86 1
PIM1 80 0
PHK 102 11
PDK1 108 4
PAK6 109 8
PAK5 63 1
PAK4 68 9
PAK2 92 8
p38 gamma MAPK 97 3
p38 delta MAPK 88 8
p38 beta MAPK 108 9
p38 alpha MAPK 82 1
NUAK1 71 0
NEK6 117 8
NEK2a 90 3
MST4 83 2
MST2 66 1
MSK1 94 4
MNK2 100 2
MNK1 110 2
MLK3 89 4
MLK1 73 0
MKK6 101 11
MKK2 101 3
MKK1 84 12
MINK1 54 9
MELK 79 2
MEKK1 98 2
MARK4 103 3
MARK3 98 5
MARK2 93 3
MARK1 79 1
MAPKAP-K3 88 2
MAPKAP-K2 91 3
LKB1 89 0
Lck 90 4
JNK3 104 9
JNK2 92 11
JNK1 90 2
JAK2 103 2
IRR 94 3
IRAK4 93 6
IR 109 3
IKK epsilon 76 3
IKK beta 93 8
IGF-1R 96 0
HIPK3 95 8
HIPK2 81 4
HIPK1 77 2
HER4 95 4
GSK3 beta 103 1
GCK 89 2
FGF-R1 80 7
ERK8 87 4
ERK2 103 4
ERK1 92 8
EPH-B4 95 13
EPH-B3 96 14
EPH-B2 100 8
EPH-B1 100 8
EPH-A4 101 1
EPH-A2 103 6
EF2K 61 6
DYRK3 91 11
DYRK2 88 5
DYRK1A 84 2
DAPK1 91 4
CSK 102 2
CLK2 96 10
CK2 111 0
CK1 delta 94 0
CHK2 89 11
CHK1 98 10
CDK2-Cyclin A 108 14
CAMKK beta 104 1
CAMK1 44 7
BTK 75 2
BRSK2 95 5
BRSK1 94 4
Aurora B 100 10
Aurora A 94 4
ASK1 109 3
AMPK 87 6
Screen Conc: 100.00µM
Kinase % Activity Remaining Standard Deviation
YES1 61 2
TBK1 100 4
SYK 44 2
SRPK1 67 0
Src 62 5
SmMLCK
-1
 0
SGK1 14 5
S6K1 34 11
RSK2 22 1
RSK1 36 1
ROCK 2 92 9
PRK2 59 2
PRAK 51 4
PLK1 83 2
PKD1 81 3
PKC zeta 104 8
PKC alpha 96 3
PKB beta 26 2
PKB alpha
6
 0
PKA 39 0
PIM3 16 1
PIM2 23 0
PIM1 17 1
PHK 59 2
PDK1 98 15
PAK6 66 1
PAK5 63 5
PAK4 33 1
p38 gamma MAPK 87 0
p38 delta MAPK 89 3
p38 beta MAPK 86 15
p38 alpha MAPK 83 2
NEK7 15 0
NEK6 44 1
NEK2a 70 2
MST4 92 6
MST2 83 7
MSK1 41 1
MNK2 77 10
MNK1 82 0
MKK1 14 3
MELK 45 5
MARK3 90 8
MAPKAP-K3 52 2
MAPKAP-K2 12 0
Lck 31 3
JNK3 42 1
JNK2 80 7
JNK1 48 1
IRR 68 1
IKK epsilon 100 1
IKK beta 98 2
HIPK3 68 2
HIPK2 61 1
GSK3 beta 43 9
FGF-R1 55 0
ERK8 51 1
ERK2 45 1
ERK1 87 2
EPH-A2 69 1
EF2K 43 1
DYRK3 60 4
DYRK2 106 0
DYRK1A 99 5
CSK 92 0
CK2 84 7
CK1 delta 88 5
CHK2 58 3
CHK1 88 5
CDK2-Cyclin A 93 3
CAMK1
8
 0
BRSK2 76 9
Aurora C 70 15
Aurora B 56 11
AMPK 97 0