Inhibitor | Princeton's TrkA inhibitor compound 20h  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
EPH-A4
0
 5
Aurora A
0
 0
IR
1
 0
CLK2
1
 0
ERK8
1
 0
IRAK4
2
 1
IGF-1R
2
 1
Src
2
 0
PHK
2
 0
AMPK
3
 1
MST2
3
 0
CDK2-Cyclin A
3
 1
CHK2
4
 1
EPH-B2
4
 0
TrkA
4
 1
EPH-B4
4
 1
HIPK1
5
 1
HIPK2
5
 0
MEKK1
5
 1
Lck
5
 3
SmMLCK
5
 0
p38 delta MAPK
5
 1
MELK
5
 2
RSK1
6
 0
EPH-B3
6
 4
YES1
6
 0
NUAK1
7
 0
Aurora B
7
 1
RIPK2
8
 2
MINK1
8
 1
LKB1
8
 1
BTK
8
 0
CSK
9
 1
PKC alpha 11 2
PIM1 11 1
CAMK1 11 0
S6K1 11 6
SRPK1 11 3
FGF-R1 11 0
EPH-A2 13 2
PAK2 16 2
MST4 17 0
HIPK3 17 1
MLK1 17 2
RSK2 18 7
CAMKK beta 19 2
VEGFR1 19 1
PAK4 20 6
PIM3 21 1
MSK1 22 5
PAK5 22 0
PAK6 27 1
TAK1 27 0
SYK 28 7
JAK2 30 0
PRK2 32 2
GCK 33 5
GSK3 beta 37 3
MKK1 40 2
BRSK2 40 1
SGK1 41 8
BRSK1 41 11
TTK 42 4
MARK4 43 3
DYRK3 43 1
MARK2 44 3
PKD1 45 5
p38 gamma MAPK 45 5
PKB beta 46 1
p38 alpha MAPK 47 5
p38 beta MAPK 48 7
HER4 51 0
MLK3 51 0
CHK1 52 6
IRR 52 0
JNK1 53 9
PKB alpha 53 1
JNK2 54 5
JNK3 54 3
PKA 54 2
MARK3 57 2
MARK1 58 1
PKC zeta 58 4
DYRK1A 61 3
ROCK 2 63 5
DAPK1 63 5
CK1 delta 68 8
NEK2a 71 4
MNK2 73 3
IKK epsilon 76 9
PIM2 77 11
MNK1 77 13
MAPKAP-K2 80 0
DYRK2 80 3
IKK beta 84 7
MAPKAP-K3 85 7
CK2 85 1
ERK2 85 8
NEK6 85 10
EF2K 92 10
TBK1 93 1
PRAK 96 9
ERK1 99 1
PDK1 106 8
PLK1 114 3
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ERK8
1
 0
IGF-1R
2
 0
CLK2
3
 0
Aurora A
3
 0
IRAK4
5
 2
EPH-B2 11 1
YES1 11 2
TrkA 14 1
HIPK2 14 2
EPH-B4 15 1
MST2 16 0
IR 19 3
CHK2 20 1
RIPK2 20 0
CAMKK beta 22 0
EPH-B3 22 3
Src 22 3
EPH-A4 22 6
HIPK3 30 2
RSK1 31 1
CDK2-Cyclin A 35 2
NUAK1 40 4
PKC alpha 41 1
MELK 42 9
TAO1 42 5
Lck 43 9
PHK 43 0
PAK2 44 6
HIPK1 45 2
MEKK1 46 1
GSK3 beta 46 1
EPH-A2 46 13
FGF-R1 47 4
MST4 50 0
SmMLCK 51 6
EPH-B1 53 0
PIM3 53 13
PIM1 54 7
CHK1 54 1
VEGFR1 56 15
MSK1 59 3
CAMK1 62 9
PAK5 62 3
AMPK 63 5
LKB1 64 4
Aurora B 65 0
RSK2 67 1
IRR 69 9
MINK1 69 12
HER4 69 8
PAK4 69 5
MARK1 70 11
SRPK1 71 12
PAK6 71 12
TTK 75 2
p38 gamma MAPK 77 2
MLK1 78 4
PKB beta 80 8
PRK2 80 13
MARK2 81 10
BRSK1 82 13
SYK 82 14
MLK3 84 3
JAK2 84 9
MKK2 86 7
TBK1 87 3
p38 beta MAPK 87 1
BRSK2 88 5
SGK1 89 4
PKD1 89 3
DYRK3 89 11
ROCK 2 90 0
MAPKAP-K3 91 6
IKK epsilon 91 3
PIM2 94 1
MKK6 94 14
JNK3 94 4
S6K1 95 6
PRAK 96 3
MKK1 96 2
BTK 96 1
PLK1 97 2
p38 delta MAPK 97 4
MNK1 97 9
PKA 98 7
JNK1 98 8
JNK2 98 1
MAPKAP-K2 98 4
ERK2 99 6
DAPK1 99 5
CK1 delta 99 6
GCK 101 4
MARK4 101 8
p38 alpha MAPK 101 9
DYRK2 101 9
MARK3 103 8
CSK 103 12
ERK1 103 9
DYRK1A 103 8
NEK6 103 5
PKC zeta 104 4
PDK1 105 0
PKB alpha 105 3
ASK1 106 1
TAK1 107 3
IKK beta 107 3
NEK2a 108 2
EF2K 113 8
CK2 119 11
MNK2 120 5
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ERK8
1
 1
IGF-1R
2
 0
CLK2
3
 0
Aurora A
3
 0
IRAK4
3
 0
EPH-B2
4
 7
YES1 11 1
Lck 13 1
HIPK2 13 0
EPH-B4 13 0
IR 14 3
CDK2-Cyclin A 15 4
PHK 15 2
MELK 15 5
RIPK2 17 0
CHK2 18 1
TrkA 19 8
MST2 19 0
CAMKK beta 19 2
EPH-B3 20 4
Src 20 3
p38 delta MAPK 24 2
RSK1 29 1
EPH-A4 29 13
HIPK3 31 3
TAO1 33 1
MEKK1 35 0
EPH-A2 36 7
EPH-B1 36 5
NUAK1 37 5
GSK3 beta 41 3
HIPK1 42 2
Aurora B 42 7
FGF-R1 43 3
SmMLCK 43 5
PAK2 44 1
PKC alpha 45 7
AMPK 47 2
PIM1 49 1
MST4 50 1
MSK1 51 1
VEGFR1 52 11
CHK1 53 10
BTK 53 3
PAK5 58 3
CAMK1 59 9
SRPK1 59 6
LKB1 62 4
RSK2 64 7
SYK 64 2
MINK1 64 4
HER4 64 15
PAK4 67 5
MLK1 69 4
PIM3 72 4
PAK6 72 5
TTK 73 9
p38 beta MAPK 76 5
MAPKAP-K3 77 2
MKK2 77 7
MLK3 77 12
PRK2 78 2
MARK1 78 9
TBK1 78 4
DYRK3 78 4
ERK1 78 6
JAK2 80 8
IKK epsilon 80 8
p38 gamma MAPK 80 6
BRSK2 80 3
IRR 80 15
BRSK1 81 9
ROCK 2 82 3
TAK1 84 7
MKK1 85 1
PKD1 85 1
PLK1 85 1
MAPKAP-K2 86 2
PKB alpha 86 10
CK1 delta 87 2
MARK2 87 5
DYRK2 87 7
NEK2a 87 1
CSK 88 12
PKA 88 0
p38 alpha MAPK 89 0
MARK3 89 1
SGK1 90 1
IKK beta 92 3
PIM2 92 1
S6K1 92 2
MNK2 92 11
GCK 93 2
JNK2 94 5
PRAK 94 1
PKB beta 94 2
MKK6 95 2
DAPK1 96 8
EF2K 96 10
PDK1 98 5
PKC zeta 98 9
JNK1 99 4
DYRK1A 101 5
ASK1 101 12
NEK6 101 3
MNK1 103 13
ERK2 103 9
CK2 104 7
JNK3 107 0
MARK4 118 13