Inhibitor | PP2  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PP2   C15H16ClN5 301.77 172889-27-9 4878 Src Kirihara T. (2013) Exp Eye Res. S0014

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
Lck
2
 1
EPH-B3
5
 1
EPH-B1
5
 1
EPH-B4
6
 0
CSK
6
 0
Src
7
 5
EPH-A4
7
 1
RIPK2
8
 1
EPH-B2
10
 0
BTK 14 2
CK1 delta 14 2
YES1 15 1
HER4 18 2
FGF-R1 19 1
EPH-A2 20 3
MKK1 25 4
p38 alpha MAPK 25 0
p38 beta MAPK 25 3
VEGFR1 26 5
PKA 28 1
MELK 35 1
MKK2 37 2
PKC alpha 39 3
TrkA 40 8
MSK1 42 2
MLK3 43 11
SmMLCK 49 2
MST4 59 2
CLK2 59 9
BRSK1 59 1
RSK1 64 3
PKD1 64 0
Aurora B 66 0
JNK3 66 10
IR 69 2
IRAK4 70 6
MST2 71 6
GCK 71 9
ERK8 71 5
CAMKK beta 72 9
IGF-1R 72 2
MNK2 73 3
CAMK1 73 10
MINK1 74 5
PAK2 74 1
PAK4 74 12
CHK2 75 10
ERK1 75 10
TAK1 77 7
RSK2 77 12
MARK3 77 5
MARK4 77 2
PAK5 78 0
MAPKAP-K3 80 10
S6K1 80 9
JNK2 81 1
JAK2 81 4
BRSK2 81 1
MNK1 82 9
IRR 82 5
MLK1 83 3
ERK2 84 2
AMPK 84 5
ROCK 2 84 2
IKK beta 85 10
MKK6 85 2
MARK2 86 7
DAPK1 87 3
LKB1 89 3
p38 delta MAPK 89 13
ASK1 91 1
HIPK2 91 5
PKB beta 91 13
TTK 91 5
DYRK2 91 8
IKK epsilon 92 1
PRK2 92 8
DYRK1A 93 8
TBK1 94 10
EF2K 94 2
NEK6 95 1
PIM2 95 4
CHK1 95 6
PKC zeta 95 2
Aurora A 96 7
PKB alpha 96 2
SYK 96 4
PAK6 96 1
PRAK 97 1
PHK 97 3
PIM3 97 5
CK2 98 6
HIPK1 99 3
MAPKAP-K2 99 3
TAO1 99 7
DYRK3 100 5
NUAK1 100 1
JNK1 101 12
PDK1 101 4
CDK2-Cyclin A 101 5
NEK2a 102 5
SGK1 102 11
p38 gamma MAPK 104 6
PIM1 105 3
MEKK1 105 11
GSK3 beta 105 2
HIPK3 108 7
SRPK1 108 2
PLK1 109 5
MARK1 115 1
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
Lck
6
 1
RIPK2
6
 2
Src
8
 3
EPH-B3
8
 0
EPH-B4
8
 0
EPH-B2
10
 2
EPH-A4 13 1
BTK 16 2
YES1 17 8
CK1 delta 17 1
CSK 21 1
HER4 24 1
EPH-B1 25 1
EPH-A2 28 4
FGF-R1 32 1
VEGFR1 34 3
p38 beta MAPK 36 6
TrkA 40 8
MKK1 51 5
CLK2 63 3
ERK8 67 4
MLK1 68 4
MELK 68 7
EF2K 68 8
PKC alpha 70 5
IKK epsilon 71 7
JNK3 71 2
MSK1 71 0
S6K1 72 0
ROCK 2 72 12
SmMLCK 73 4
MINK1 74 6
p38 alpha MAPK 74 2
CDK2-Cyclin A 76 14
ERK2 77 0
PKA 77 6
MST4 77 3
MST2 78 4
JAK2 78 8
BRSK2 78 7
IRAK4 78 10
p38 delta MAPK 79 2
MNK2 79 0
TAO1 80 9
GSK3 beta 80 2
MKK2 81 13
RSK1 81 6
TTK 81 11
ERK1 82 6
LKB1 82 3
AMPK 82 6
CAMKK beta 82 6
IR 84 13
IRR 84 9
Aurora B 84 9
JNK2 84 3
BRSK1 84 13
PIM3 84 4
HIPK1 84 2
PAK4 85 5
PKD1 85 7
CHK2 86 2
RSK2 86 1
CAMK1 87 10
PRK2 87 10
MLK3 87 13
HIPK2 87 15
PKB beta 88 8
DYRK3 88 5
PAK6 88 5
CHK1 88 11
MNK1 88 5
DAPK1 89 11
MARK3 89 8
MAPKAP-K3 89 10
PAK2 89 1
MKK6 90 5
TAK1 90 12
NUAK1 91 1
PDK1 91 1
PRAK 91 9
GCK 92 9
MARK1 92 4
MEKK1 92 5
HIPK3 92 6
MARK4 93 7
p38 gamma MAPK 93 10
CK2 93 9
PKB alpha 93 8
DYRK1A 94 7
MARK2 95 0
NEK6 96 2
TBK1 96 7
PAK5 97 5
SYK 97 8
NEK2a 98 7
PHK 99 4
IGF-1R 99 10
IKK beta 100 10
PLK1 101 4
JNK1 101 1
PIM2 101 1
ASK1 101 12
PKC zeta 103 7
DYRK2 104 3
Aurora A 105 8
PIM1 106 1
SRPK1 107 9
MAPKAP-K2 107 3
SGK1 109 0
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
BTK
9
 2
YES1 11 0
Src 17 0
EPH-B3 23 12
EPH-A2 29 9
Lck 30 0
CK1 delta 59 5
CSK 67 7
IRR 72 3
FGF-R1 75 16
CAMKK beta 75 11
TBK1 76 11
PRK2 78 1
PKB beta 79 12
MAPKAP-K2 79 13
p38 beta MAPK 81 1
ROCK 2 82 5
GSK3 beta 82 8
IR 82 16
PKA 84 0
MKK1 85 0
S6K1 86 9
PKD1 87 6
IKK beta 87 10
MELK 87 6
IKK epsilon 87 3
CDK2-Cyclin A 87 1
NEK6 88 5
MSK1 88 3
VEGFR1 88 3
NEK2a 89 5
PAK4 90 2
p38 gamma MAPK 91 25
p38 delta MAPK 91 17
CHK1 91 0
JNK2 91 2
DYRK2 92 8
MST4 93 6
MST2 93 2
DYRK1A 93 1
PDK1 93 7
PLK1 93 3
PHK 94 2
BRSK2 94 6
PIM3 94 2
PAK5 94 10
DYRK3 95 8
ERK8 95 1
PAK6 95 4
MARK3 96 13
SRPK1 96 12
ERK1 96 3
EF2K 96 3
AMPK 97 3
PIM2 97 2
IGF-1R 97 9
JNK1 97 9
PKC alpha 97 0
PKB alpha 98 11
PIM1 98 15
MNK1 98 2
CK2 100 1
PKC zeta 101 3
CAMK1 102 7
ERK2 102 0
RSK1 102 4
SmMLCK 104 8
p38 alpha MAPK 105 15
SGK1 105 6
SYK 105 3
HIPK2 105 20
PRAK 106 6
CHK2 109 0
MNK2 111 19
RSK2 125 25