Inhibitor | Pirfenidone  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Pirfenidone   C12H11NO 185.23 53179-13-8 40632 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125 Iyer (1999) J.Pharmacol.Exp.Ther. 289 211

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
MKK2 35 8
MKK1 65 10
MARK4 74 3
TTK 76 7
CAMK1 81 1
TESK1 82 8
PLK1 82 9
p38 alpha MAPK 83 7
ROCK 2 84 6
MAPKAP-K3 84 9
JNK2 86 1
JNK3 86 11
ERK8 86 13
EF2K 87 6
Aurora B 87 0
JNK1 87 3
RIPK2 87 7
CSK 87 1
MKK6 88 7
IKK beta 88 6
PAK4 89 4
SmMLCK 89 0
SRPK1 89 8
MLK1 89 8
JAK2 90 10
STK33 90 4
CHK1 90 2
TSSK1 91 16
PKB beta 91 8
DYRK1A 91 15
PRK2 91 1
NEK6 91 9
PKD1 91 6
p38 delta MAPK 91 2
TBK1 91 0
BRK 92 16
MNK2 93 7
IRAK1 93 27
MAPKAP-K2 93 2
DYRK3 93 5
BRSK1 93 4
PKC gamma 94 8
RSK2 94 0
LKB1 95 14
IRAK4 95 0
NEK2a 95 8
PRAK 95 7
MSK1 95 3
PIM3 95 8
PDK1 95 3
HIPK3 96 6
PAK5 96 2
PAK6 96 3
p38 gamma MAPK 96 8
MPSK1 96 6
PHK 96 6
BRSK2 96 3
PIM2 96 7
CDK2-Cyclin A 97 0
ERK2 97 1
PKA 97 7
PKC zeta 97 13
CHK2 97 0
MLK3 98 5
DYRK2 98 3
MARK1 98 6
MELK 98 10
GSK3 beta 99 0
IRR 99 7
EPH-A4 99 9
ASK1 99 3
MNK1 99 0
IKK epsilon 99 2
SGK1 100 4
TAO1 100 5
PAK2 100 6
ZAP70 100 21
DAPK1 100 16
NUAK1 100 6
CK1 delta 102 13
MARK2 102 1
MST4 102 2
Src 102 5
Lck 102 12
IGF-1R 102 1
PKB alpha 102 12
CK2 103 4
HIPK1 103 4
SYK 103 9
AMPK 103 2
MEKK1 103 0
IR 103 3
EPH-B1 104 2
FGF-R1 104 22
EIF2AK3 105 3
HIPK2 106 14
PIM1 106 12
HER4 106 19
VEGFR1 107 15
Aurora A 107 2
TTBK1 107 15
CAMKK beta 108 2
MARK3 108 3
GCK 108 0
MINK1 108 3
EPH-B2 109 3
YES1 109 2
S6K1 111 7
p38 beta MAPK 111 1
EPH-A2 111 3
ABL 112 15
TrkA 112 3
CLK2 112 7
EPH-B3 112 15
MST2 112 10
RSK1 114 1
BTK 115 10
ERK1 115 6
TLK1 115 1
OSR1 115 8
PKC alpha 118 9
TIE2 118 18
TAK1 119 35
EPH-B4 120 8
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
MKK2 58 4
TTK 73 11
MKK1 77 0
STK33 82 9
IRAK4 83 4
JNK3 83 1
EF2K 83 2
JNK1 85 2
JNK2 85 12
RIPK2 86 11
IKK beta 87 10
MPSK1 87 0
TSSK1 87 11
PAK5 88 4
MNK2 90 2
PKA 90 10
MAPKAP-K3 92 4
Aurora B 93 5
ROCK 2 94 8
MELK 94 4
TESK1 94 6
ERK2 95 4
BRSK1 95 10
SRPK1 95 9
MLK1 95 12
ERK8 95 8
EPH-B3 96 5
Lck 96 18
PLK1 96 1
PDK1 97 9
CAMKK beta 97 1
CHK1 97 8
CK1 delta 97 12
p38 delta MAPK 97 10
RSK2 98 2
CAMK1 98 3
MARK4 98 25
CSK 98 1
CK2 98 0
MSK1 98 5
AMPK 99 5
PKB beta 99 11
MARK1 99 16
NEK6 99 2
TBK1 99 14
PKC alpha 99 20
PKC gamma 99 11
SYK 99 17
HIPK3 100 12
PRAK 100 2
VEGFR1 100 13
MNK1 101 12
BRK 101 5
PAK2 101 7
PAK4 101 8
FGF-R1 101 8
SmMLCK 102 8
p38 alpha MAPK 102 10
GSK3 beta 102 2
DYRK1A 103 1
TAK1 103 21
LKB1 103 16
DYRK3 103 9
PHK 103 0
CDK2-Cyclin A 103 5
JAK2 103 7
TrkA 103 14
MARK2 104 7
IKK epsilon 104 7
IRR 104 3
IRAK1 105 6
MST4 105 6
PIM1 105 9
IGF-1R 105 5
EPH-A4 106 9
MKK6 106 5
PAK6 106 8
GCK 106 9
BRSK2 106 0
MINK1 106 1
MEKK1 106 6
ABL 106 5
EIF2AK3 106 9
Aurora A 106 4
RSK1 107 4
DYRK2 107 2
NEK2a 107 9
MAPKAP-K2 108 5
PKB alpha 108 11
MARK3 108 0
MLK3 108 16
EPH-B1 109 22
PKC zeta 109 5
p38 gamma MAPK 109 3
TIE2 110 4
IR 110 4
ZAP70 110 1
PIM3 111 5
MST2 112 15
EPH-B4 112 9
DAPK1 112 3
TLK1 113 6
EPH-A2 113 11
SGK1 113 4
OSR1 114 20
ASK1 114 25
S6K1 115 10
NUAK1 115 1
PIM2 118 8
YES1 118 8
HIPK1 118 3
TAO1 118 4
CHK2 119 7
BTK 119 4
CLK2 120 16
EPH-B2 120 19
p38 beta MAPK 120 11
PRK2 121 9
PKD1 122 12
HIPK2 122 2
Src 123 11
HER4 123 23
TTBK1 124 0
ERK1 125 13