Inhibitor | A-769662  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
A-769662   C20H12N2O3S 360.39 844499-71-4 54708532 AMPK Activator Cool B. (2006) Cell Metabolism 3 403-416

Screening Results Chart

Screening Results Tables

Screen Conc: 50.00µM
Kinase % Activity Remaining Standard Deviation
YES1 13 2
TBK1 55 4
SYK 36 3
SRPK1 42 8
Src 65 13
SmMLCK 39 12
SGK1 54 1
S6K1 66 5
RSK2 27 7
RSK1
9
 0
ROCK 2 49 7
PRK2 85 9
PRAK 25 1
PLK1 28 1
PKD1 25 12
PKC zeta 67 6
PKC alpha 60 0
PKB beta 37 5
PKB alpha 62 1
PKA 41 10
PIM3
5
 0
PIM2 17 0
PIM1
5
 0
PHK 65 3
PDK1 81 0
PAK6 92 11
PAK5 50 6
PAK4 38 0
p38 gamma MAPK 80 6
p38 delta MAPK 116 12
p38 beta MAPK 84 4
p38 alpha MAPK 122 12
NEK7 102 4
NEK6 94 8
NEK2a 52 9
MST4 57 3
MST2 36 0
MSK1 39 4
MNK2 80 4
MNK1 66 4
MKK1 27 10
MELK 64 5
MARK3 87 4
MAPKAP-K3 48 1
MAPKAP-K2 32 2
Lck 58 4
JNK3 70 4
JNK2 89 10
JNK1 102 3
IRR 90 4
IKK epsilon 47 1
IKK beta 60 0
HIPK3 52 2
HIPK2 58 2
GSK3 beta 17 4
FGF-R1 95 11
ERK8 36 4
ERK2 74 2
ERK1 102 3
EPH-A2 64 6
EF2K 73 3
DYRK3 47 4
DYRK2 84 0
DYRK1A 60 10
CSK 46 1
CK2 95 0
CK1 delta 60 6
CHK2 52 4
CHK1 98 4
CDK2-Cyclin A 84 6
CAMKK beta 48 9
CAMK1 45 0
BRSK2 63 4
Aurora C 30 4
Aurora B 25 2
AMPK 67 3
Screen Conc: 100.00µM
Kinase % Activity Remaining Standard Deviation
YES1 16 0
VEGFR1 11 2
TTK 48 1
TrkA 28 4
TBK1 29 2
TAO1 18 1
TAK1 72 8
SYK 42 10
SRPK1 35 1
Src
10
 1
SmMLCK 20 0
SGK1 48 1
S6K1 38 1
RSK2 13 2
RSK1 12 5
ROCK 2 75 5
RIPK2 139 3
PRK2 59 2
PRAK 15 4
PLK1 25 2
PKD1 24 1
PKC zeta 28 6
PKC alpha 90 11
PKB beta 11 2
PKB alpha 78 2
PKA 95 10
PIM3
7
 2
PIM2 18 1
PIM1
7
 1
PHK 73 1
PDK1 90 2
PAK6 82 8
PAK5 39 1
PAK4 41 2
PAK2 63 8
p38 gamma MAPK 83 6
p38 delta MAPK 124 10
p38 beta MAPK 77 3
p38 alpha MAPK 90 5
NUAK1
10
 0
NEK6 137 5
NEK2a 19 0
MST4 14 0
MST2 20 0
MSK1 42 7
MNK2 86 1
MNK1 93 5
MLK3
4
 1
MLK1 18 2
MKK6 84 10
MKK2 19 0
MKK1 29 3
MINK1
5
 0
MELK 21 0
MEKK1
7
 0
MARK4 45 4
MARK3 38 4
MARK2 49 2
MARK1 68 6
MAPKAP-K3
8
 3
MAPKAP-K2 30 4
LKB1 65 6
Lck 58 5
JNK3 62 11
JNK2 88 1
JNK1 93 8
JAK2 32 1
IRR 51 6
IRAK4 34 3
IR 69 9
IKK epsilon 12 0
IKK beta 39 3
IGF-1R 65 5
HIPK3 43 6
HIPK2 19 3
HIPK1 35 2
HER4
8
 4
GSK3 beta 46 6
GCK 14 2
FGF-R1 50 8
ERK8 24 4
ERK2 49 10
ERK1 63 11
EPH-B4 49 4
EPH-B3 55 4
EPH-B2 13 2
EPH-B1 97 4
EPH-A4 64 4
EPH-A2 40 5
EF2K 64 5
DYRK3
6
 1
DYRK2 33 2
DYRK1A 26 3
DAPK1 83 5
CSK 82 10
CLK2 30 4
CK2 86 5
CK1 delta 88 4
CHK2 33 3
CHK1 43 3
CDK2-Cyclin A 121 0
CAMKK beta 78 4
CAMK1
7
 1
BTK
10
 1
BRSK2 28 1
BRSK1 51 4
Aurora B 22 2
Aurora A 64 4
ASK1 250 7
AMPK 62 5
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
YES1 96 7
VEGFR1 65 4
TTK 76 2
TrkA 69 2
TBK1 67 8
TAO1 83 4
TAK1 83 3
SYK 106 0
SRPK1 107 0
Src 44 5
SmMLCK 76 2
SGK1 103 1
S6K1 78 1
RSK2 74 4
RSK1 80 7
ROCK 2 91 2
RIPK2 110 4
PRK2 85 8
PRAK 52 4
PLK1 88 1
PKD1 62 6
PKC zeta 96 7
PKC alpha 94 6
PKB beta 56 5
PKB alpha 94 0
PKA 89 1
PIM3 18 1
PIM2 71 5
PIM1 26 2
PHK 96 0
PDK1 93 3
PAK6 69 3
PAK5 58 2
PAK4 52 8
PAK2 94 2
p38 gamma MAPK 95 3
p38 delta MAPK 107 7
p38 beta MAPK 89 2
p38 alpha MAPK 97 2
NUAK1 61 7
NEK6 104 6
NEK2a 73 1
MST4 74 5
MST2 60 10
MSK1 69 3
MNK2 102 3
MNK1 104 2
MLK3 43 6
MLK1 59 4
MKK6 85 15
MKK2 74 3
MKK1 79 1
MINK1 65 6
MELK 46 1
MEKK1 26 5
MARK4 92 6
MARK3 78 4
MARK2 64 4
MARK1 59 3
MAPKAP-K3 57 1
MAPKAP-K2 77 1
LKB1 86 3
Lck 88 5
JNK3 75 3
JNK2 94 1
JNK1 99 5
JAK2 83 6
IRR 88 5
IRAK4 82 4
IR 103 1
IKK epsilon 69 4
IKK beta 86 0
IGF-1R 94 8
HIPK3 97 1
HIPK2 99 6
HIPK1 74 7
HER4 33 7
GSK3 beta 80 1
GCK 76 5
FGF-R1 109 11
ERK8 81 3
ERK2 103 8
ERK1 83 3
EPH-B4 82 8
EPH-B3 81 11
EPH-B2 93 5
EPH-B1 110 6
EPH-A4 93 1
EPH-A2 82 7
EF2K 89 4
DYRK3 54 6
DYRK2 63 0
DYRK1A 75 3
DAPK1 107 1
CSK 79 2
CLK2 81 2
CK2 110 5
CK1 delta 88 5
CHK2 79 4
CHK1 69 2
CDK2-Cyclin A 100 3
CAMKK beta 87 5
CAMK1 68 3
BTK 52 5
BRSK2 64 4
BRSK1 76 5
Aurora B 53 0
Aurora A 93 7
ASK1 140 5
AMPK 135 15