| Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
|---|---|---|---|---|---|---|---|
| IRAK-4 kinase inhibitor a | C22H24N4O6 | 440.45 | IRAK4 | Wang Z. (2006) Structure 14 1835-1844 |
| Kinase | % Activity Remaining Sort descending | Standard Deviation |
|---|---|---|
| IRAK4 |
2
|
1 |
| CLK2 |
6
|
2 |
| CK1 delta |
10
|
1 |
| MINK1 | 14 | 3 |
| TAK1 | 17 | 4 |
| TrkA | 27 | 3 |
| DYRK1A | 28 | 4 |
| MLK3 | 30 | 4 |
| GCK | 32 | 2 |
| VEGFR1 | 35 | 7 |
| PHK | 35 | 1 |
| CAMKK beta | 44 | 1 |
| DYRK3 | 44 | 2 |
| SRPK1 | 44 | 3 |
| MLK1 | 47 | 0 |
| IRR | 47 | 0 |
| TTK | 55 | 8 |
| GSK3 beta | 59 | 4 |
| Aurora B | 60 | 1 |
| MEKK1 | 61 | 3 |
| NUAK1 | 62 | 9 |
| RSK1 | 66 | 1 |
| PAK4 | 66 | 3 |
| PIM1 | 69 | 1 |
| SmMLCK | 69 | 2 |
| MARK4 | 69 | 2 |
| DYRK2 | 70 | 2 |
| MST4 | 71 | 0 |
| BTK | 71 | 6 |
| MSK1 | 73 | 3 |
| RSK2 | 73 | 5 |
| PIM3 | 73 | 2 |
| PKB beta | 74 | 10 |
| PIM2 | 74 | 3 |
| MARK2 | 74 | 3 |
| CHK1 | 75 | 2 |
| NEK2a | 76 | 9 |
| Lck | 76 | 2 |
| MARK1 | 77 | 1 |
| JNK3 | 77 | 0 |
| NEK6 | 77 | 1 |
| CHK2 | 78 | 6 |
| AMPK | 79 | 8 |
| DAPK1 | 79 | 6 |
| MKK1 | 79 | 3 |
| BRSK2 | 80 | 3 |
| MELK | 80 | 9 |
| p38 beta MAPK | 81 | 9 |
| Aurora A | 81 | 2 |
| BRSK1 | 81 | 1 |
| S6K1 | 81 | 6 |
| FGF-R1 | 81 | 1 |
| HIPK2 | 83 | 1 |
| MKK2 | 83 | 8 |
| p38 alpha MAPK | 83 | 5 |
| MAPKAP-K3 | 83 | 5 |
| MARK3 | 84 | 4 |
| ERK8 | 84 | 8 |
| TAO1 | 85 | 3 |
| ROCK 2 | 85 | 14 |
| p38 gamma MAPK | 85 | 5 |
| EPH-B3 | 86 | 9 |
| PDK1 | 86 | 4 |
| CSK | 87 | 4 |
| TBK1 | 87 | 13 |
| PAK5 | 87 | 1 |
| PAK6 | 87 | 5 |
| MST2 | 87 | 2 |
| RIPK2 | 88 | 1 |
| PRAK | 88 | 6 |
| MKK6 | 88 | 5 |
| ERK1 | 89 | 3 |
| JAK2 | 89 | 1 |
| IKK epsilon | 90 | 2 |
| EPH-B2 | 92 | 11 |
| SGK1 | 92 | 5 |
| PRK2 | 92 | 2 |
| CAMK1 | 92 | 11 |
| PLK1 | 92 | 3 |
| p38 delta MAPK | 93 | 11 |
| ERK2 | 93 | 11 |
| PKB alpha | 93 | 4 |
| PKA | 93 | 1 |
| CK2 | 94 | 12 |
| PKC alpha | 94 | 8 |
| LKB1 | 94 | 7 |
| HIPK1 | 94 | 6 |
| SYK | 96 | 1 |
| YES1 | 96 | 6 |
| JNK2 | 96 | 1 |
| PKD1 | 96 | 3 |
| CDK2-Cyclin A | 97 | 7 |
| MNK1 | 97 | 10 |
| EPH-A4 | 97 | 2 |
| HIPK3 | 98 | 2 |
| Src | 98 | 5 |
| PKC zeta | 98 | 15 |
| MAPKAP-K2 | 99 | 8 |
| ASK1 | 101 | 11 |
| EF2K | 101 | 7 |
| JNK1 | 103 | 2 |
| IGF-1R | 103 | 3 |
| IR | 103 | 4 |
| MNK2 | 104 | 3 |
| HER4 | 106 | 12 |
| EPH-B1 | 106 | 7 |
| EPH-A2 | 109 | 6 |
| IKK beta | 111 | 6 |
| EPH-B4 | 112 | 5 |
| PAK2 | 121 | 14 |
| Kinase | % Activity Remaining Sort descending | Standard Deviation |
|---|---|---|
| IRAK4 |
6
|
0 |
| IRAK1 | 11 | 3 |
| MINK1 | 30 | 2 |
| CLK2 | 50 | 13 |
| DYRK1A | 54 | 2 |
| PHK | 62 | 6 |
| IRR | 69 | 10 |
| TAK1 | 71 | 11 |
| CK1 delta | 72 | 2 |
| MKK2 | 77 | 15 |
| PKB beta | 79 | 2 |
| Aurora B | 80 | 4 |
| RSK2 | 80 | 20 |
| SmMLCK | 81 | 20 |
| MLK3 | 81 | 5 |
| CK2 | 81 | 12 |
| PKD1 | 82 | 1 |
| ERK8 | 83 | 21 |
| VEGFR1 | 83 | 9 |
| STK33 | 84 | 4 |
| DYRK3 | 86 | 1 |
| MARK4 | 86 | 5 |
| NUAK1 | 86 | 18 |
| HIPK2 | 87 | 11 |
| IKK beta | 87 | 0 |
| DAPK1 | 87 | 9 |
| TTBK1 | 87 | 14 |
| IGF-1R | 88 | 2 |
| CSK | 88 | 7 |
| CDK2-Cyclin A | 89 | 7 |
| BRSK2 | 89 | 9 |
| PIM2 | 90 | 1 |
| ASK1 | 90 | 7 |
| HIPK3 | 90 | 16 |
| SRPK1 | 90 | 13 |
| NEK2a | 90 | 0 |
| MPSK1 | 91 | 17 |
| PAK4 | 91 | 0 |
| JAK2 | 91 | 3 |
| IR | 91 | 5 |
| MAPKAP-K3 | 91 | 1 |
| TTK | 91 | 8 |
| SGK1 | 91 | 2 |
| MKK1 | 92 | 1 |
| NEK6 | 92 | 15 |
| Lck | 92 | 11 |
| GCK | 92 | 13 |
| JNK2 | 93 | 4 |
| Src | 93 | 15 |
| EPH-A2 | 93 | 7 |
| LKB1 | 93 | 9 |
| MARK3 | 93 | 10 |
| PKA | 94 | 5 |
| BTK | 94 | 16 |
| PAK5 | 94 | 11 |
| OSR1 | 94 | 10 |
| p38 alpha MAPK | 94 | 2 |
| EF2K | 94 | 4 |
| GSK3 beta | 95 | 6 |
| JNK3 | 95 | 7 |
| MARK2 | 95 | 14 |
| CHK1 | 95 | 2 |
| RIPK2 | 96 | 13 |
| ROCK 2 | 97 | 7 |
| SYK | 97 | 18 |
| TBK1 | 97 | 9 |
| PAK2 | 98 | 7 |
| RSK1 | 98 | 11 |
| PIM3 | 98 | 6 |
| ERK1 | 98 | 11 |
| MELK | 98 | 5 |
| CAMKK beta | 98 | 1 |
| MSK1 | 99 | 5 |
| MLK1 | 99 | 5 |
| TrkA | 99 | 14 |
| EPH-B3 | 99 | 25 |
| EIF2AK3 | 99 | 9 |
| p38 delta MAPK | 100 | 8 |
| S6K1 | 100 | 5 |
| TAO1 | 100 | 26 |
| MARK1 | 100 | 3 |
| HER4 | 100 | 15 |
| PIM1 | 101 | 6 |
| MEKK1 | 101 | 13 |
| Aurora A | 101 | 16 |
| AMPK | 101 | 17 |
| CHK2 | 102 | 12 |
| MST2 | 102 | 7 |
| EPH-B4 | 102 | 4 |
| JNK1 | 103 | 2 |
| EPH-A4 | 103 | 1 |
| PDK1 | 103 | 13 |
| p38 beta MAPK | 103 | 2 |
| PRAK | 103 | 9 |
| PRK2 | 104 | 14 |
| MNK2 | 104 | 2 |
| PKC gamma | 104 | 7 |
| ERK2 | 104 | 8 |
| PAK6 | 104 | 13 |
| ZAP70 | 104 | 22 |
| ABL | 105 | 8 |
| HIPK1 | 106 | 24 |
| BRSK1 | 106 | 14 |
| TSSK1 | 106 | 21 |
| TLK1 | 106 | 11 |
| DYRK2 | 106 | 17 |
| BRK | 107 | 0 |
| MNK1 | 107 | 0 |
| PLK1 | 107 | 5 |
| PKC zeta | 107 | 3 |
| p38 gamma MAPK | 107 | 18 |
| TIE2 | 108 | 9 |
| PKB alpha | 108 | 3 |
| MST4 | 109 | 10 |
| EPH-B2 | 110 | 7 |
| TESK1 | 110 | 8 |
| FGF-R1 | 111 | 16 |
| IKK epsilon | 113 | 11 |
| EPH-B1 | 118 | 3 |
| PKC alpha | 119 | 6 |
| MAPKAP-K2 | 121 | 6 |
| YES1 | 122 | 4 |
| CAMK1 | 134 | 7 |
| MKK6 | 138 | 63 |
| Kinase | % Activity Remaining Sort descending | Standard Deviation |
|---|---|---|
| IRAK4 |
6
|
4 |
| IRAK1 | 15 | 2 |
| CLK2 | 49 | 2 |
| TAK1 | 55 | 15 |
| CK2 | 65 | 7 |
| MINK1 | 66 | 0 |
| MKK2 | 67 | 17 |
| IRR | 68 | 0 |
| ERK8 | 69 | 1 |
| Aurora B | 70 | 16 |
| PKD1 | 76 | 13 |
| HIPK3 | 77 | 7 |
| EF2K | 78 | 13 |
| CK1 delta | 78 | 6 |
| STK33 | 82 | 3 |
| MKK1 | 83 | 23 |
| NEK6 | 83 | 9 |
| MARK4 | 84 | 9 |
| TBK1 | 84 | 6 |
| GSK3 beta | 84 | 6 |
| EPH-B3 | 84 | 6 |
| NUAK1 | 85 | 4 |
| GCK | 85 | 12 |
| NEK2a | 85 | 11 |
| JNK2 | 86 | 3 |
| p38 delta MAPK | 86 | 15 |
| LKB1 | 86 | 4 |
| CSK | 86 | 6 |
| MARK2 | 87 | 8 |
| MLK3 | 87 | 5 |
| JAK2 | 87 | 9 |
| DAPK1 | 87 | 7 |
| PIM2 | 87 | 0 |
| TTK | 87 | 12 |
| MPSK1 | 87 | 19 |
| PAK2 | 87 | 11 |
| MAPKAP-K3 | 87 | 7 |
| MST2 | 88 | 14 |
| IGF-1R | 88 | 16 |
| SGK1 | 89 | 8 |
| SYK | 89 | 23 |
| p38 alpha MAPK | 89 | 22 |
| PAK5 | 89 | 6 |
| CAMKK beta | 90 | 0 |
| ERK1 | 90 | 7 |
| TIE2 | 90 | 5 |
| CHK1 | 90 | 15 |
| p38 gamma MAPK | 90 | 5 |
| YES1 | 90 | 2 |
| MARK1 | 90 | 8 |
| IR | 91 | 0 |
| MARK3 | 91 | 2 |
| TrkA | 91 | 15 |
| PKA | 91 | 9 |
| BRSK1 | 91 | 13 |
| ASK1 | 91 | 9 |
| HIPK2 | 91 | 22 |
| DYRK1A | 91 | 4 |
| EPH-B4 | 91 | 3 |
| AMPK | 91 | 8 |
| ROCK 2 | 92 | 12 |
| PIM3 | 92 | 1 |
| CDK2-Cyclin A | 92 | 6 |
| MLK1 | 93 | 5 |
| S6K1 | 93 | 35 |
| VEGFR1 | 93 | 1 |
| MELK | 93 | 3 |
| CHK2 | 93 | 5 |
| SRPK1 | 93 | 9 |
| EPH-A2 | 93 | 4 |
| RIPK2 | 93 | 21 |
| HIPK1 | 93 | 8 |
| MNK1 | 93 | 7 |
| MNK2 | 93 | 4 |
| PDK1 | 93 | 7 |
| IKK epsilon | 94 | 10 |
| PHK | 94 | 7 |
| EIF2AK3 | 94 | 0 |
| PLK1 | 94 | 0 |
| RSK1 | 94 | 3 |
| PAK4 | 94 | 10 |
| PRK2 | 95 | 7 |
| JNK3 | 95 | 6 |
| BRK | 95 | 19 |
| p38 beta MAPK | 95 | 15 |
| Lck | 95 | 19 |
| DYRK3 | 95 | 3 |
| PKB beta | 95 | 13 |
| IKK beta | 96 | 4 |
| ERK2 | 96 | 18 |
| TSSK1 | 96 | 10 |
| EPH-A4 | 96 | 4 |
| TTBK1 | 96 | 11 |
| RSK2 | 96 | 5 |
| TLK1 | 96 | 10 |
| DYRK2 | 96 | 7 |
| MEKK1 | 96 | 0 |
| BTK | 97 | 9 |
| TESK1 | 97 | 9 |
| JNK1 | 97 | 2 |
| PIM1 | 97 | 10 |
| MST4 | 97 | 20 |
| SmMLCK | 98 | 1 |
| BRSK2 | 98 | 5 |
| TAO1 | 99 | 9 |
| ZAP70 | 99 | 2 |
| HER4 | 99 | 5 |
| OSR1 | 100 | 8 |
| MSK1 | 100 | 17 |
| Aurora A | 101 | 8 |
| ABL | 102 | 7 |
| PKB alpha | 102 | 7 |
| MAPKAP-K2 | 104 | 6 |
| PKC gamma | 105 | 0 |
| PKC alpha | 106 | 18 |
| PAK6 | 107 | 3 |
| FGF-R1 | 108 | 1 |
| PRAK | 110 | 18 |
| EPH-B1 | 111 | 13 |
| Src | 111 | 21 |
| PKC zeta | 114 | 16 |
| EPH-B2 | 117 | 9 |
| CAMK1 | 118 | 20 |
| MKK6 | 126 | 9 |