Inhibitor | IRAK-4 kinase inhibitor a  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IRAK-4 kinase inhibitor a   C22H24N4O6 440.45 IRAK4 Wang Z. (2006) Structure 14 1835-1844

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 102 7
AMPK 91 8
ASK1 91 9
Aurora A 101 8
Aurora B 70 16
BRK 95 19
BRSK1 91 13
BRSK2 98 5
BTK 97 9
CAMK1 118 20
CAMKK beta 90 0
CDK2-Cyclin A 92 6
CHK1 90 15
CHK2 93 5
CK1 delta 78 6
CK2 65 7
CLK2 49 2
CSK 86 6
DAPK1 87 7
DYRK1A 91 4
DYRK2 96 7
DYRK3 95 3
EF2K 78 13
EIF2AK3 94 0
EPH-A2 93 4
EPH-A4 96 4
EPH-B1 111 13
EPH-B2 117 9
EPH-B3 84 6
EPH-B4 91 3
ERK1 90 7
ERK2 96 18
ERK8 69 1
FGF-R1 108 1
GCK 85 12
GSK3 beta 84 6
HER4 99 5
HIPK1 93 8
HIPK2 91 22
HIPK3 77 7
IGF-1R 88 16
IKK beta 96 4
IKK epsilon 94 10
IR 91 0
IRAK1 15 2
IRAK4
6
 4
IRR 68 0
JAK2 87 9
JNK1 97 2
JNK2 86 3
JNK3 95 6
Lck 95 19
LKB1 86 4
MAPKAP-K2 104 6
MAPKAP-K3 87 7
MARK1 90 8
MARK2 87 8
MARK3 91 2
MARK4 84 9
MEKK1 96 0
MELK 93 3
MINK1 66 0
MKK1 83 23
MKK2 67 17
MKK6 126 9
MLK1 93 5
MLK3 87 5
MNK1 93 7
MNK2 93 4
MPSK1 87 19
MSK1 100 17
MST2 88 14
MST4 97 20
NEK2a 85 11
NEK6 83 9
NUAK1 85 4
OSR1 100 8
p38 alpha MAPK 89 22
p38 beta MAPK 95 15
p38 delta MAPK 86 15
p38 gamma MAPK 90 5
PAK2 87 11
PAK4 94 10
PAK5 89 6
PAK6 107 3
PDK1 93 7
PHK 94 7
PIM1 97 10
PIM2 87 0
PIM3 92 1
PKA 91 9
PKB alpha 102 7
PKB beta 95 13
PKC alpha 106 18
PKC gamma 105 0
PKC zeta 114 16
PKD1 76 13
PLK1 94 0
PRAK 110 18
PRK2 95 7
RIPK2 93 21
ROCK 2 92 12
RSK1 94 3
RSK2 96 5
S6K1 93 35
SGK1 89 8
SmMLCK 98 1
Src 111 21
SRPK1 93 9
STK33 82 3
SYK 89 23
TAK1 55 15
TAO1 99 9
TBK1 84 6
TESK1 97 9
TIE2 90 5
TLK1 96 10
TrkA 91 15
TSSK1 96 10
TTBK1 96 11
TTK 87 12
VEGFR1 93 1
YES1 90 2
ZAP70 99 2
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 105 8
AMPK 101 17
ASK1 90 7
Aurora A 101 16
Aurora B 80 4
BRK 107 0
BRSK1 106 14
BRSK2 89 9
BTK 94 16
CAMK1 134 7
CAMKK beta 98 1
CDK2-Cyclin A 89 7
CHK1 95 2
CHK2 102 12
CK1 delta 72 2
CK2 81 12
CLK2 50 13
CSK 88 7
DAPK1 87 9
DYRK1A 54 2
DYRK2 106 17
DYRK3 86 1
EF2K 94 4
EIF2AK3 99 9
EPH-A2 93 7
EPH-A4 103 1
EPH-B1 118 3
EPH-B2 110 7
EPH-B3 99 25
EPH-B4 102 4
ERK1 98 11
ERK2 104 8
ERK8 83 21
FGF-R1 111 16
GCK 92 13
GSK3 beta 95 6
HER4 100 15
HIPK1 106 24
HIPK2 87 11
HIPK3 90 16
IGF-1R 88 2
IKK beta 87 0
IKK epsilon 113 11
IR 91 5
IRAK1 11 3
IRAK4
6
 0
IRR 69 10
JAK2 91 3
JNK1 103 2
JNK2 93 4
JNK3 95 7
Lck 92 11
LKB1 93 9
MAPKAP-K2 121 6
MAPKAP-K3 91 1
MARK1 100 3
MARK2 95 14
MARK3 93 10
MARK4 86 5
MEKK1 101 13
MELK 98 5
MINK1 30 2
MKK1 92 1
MKK2 77 15
MKK6 138 63
MLK1 99 5
MLK3 81 5
MNK1 107 0
MNK2 104 2
MPSK1 91 17
MSK1 99 5
MST2 102 7
MST4 109 10
NEK2a 90 0
NEK6 92 15
NUAK1 86 18
OSR1 94 10
p38 alpha MAPK 94 2
p38 beta MAPK 103 2
p38 delta MAPK 100 8
p38 gamma MAPK 107 18
PAK2 98 7
PAK4 91 0
PAK5 94 11
PAK6 104 13
PDK1 103 13
PHK 62 6
PIM1 101 6
PIM2 90 1
PIM3 98 6
PKA 94 5
PKB alpha 108 3
PKB beta 79 2
PKC alpha 119 6
PKC gamma 104 7
PKC zeta 107 3
PKD1 82 1
PLK1 107 5
PRAK 103 9
PRK2 104 14
RIPK2 96 13
ROCK 2 97 7
RSK1 98 11
RSK2 80 20
S6K1 100 5
SGK1 91 2
SmMLCK 81 20
Src 93 15
SRPK1 90 13
STK33 84 4
SYK 97 18
TAK1 71 11
TAO1 100 26
TBK1 97 9
TESK1 110 8
TIE2 108 9
TLK1 106 11
TrkA 99 14
TSSK1 106 21
TTBK1 87 14
TTK 91 8
VEGFR1 83 9
YES1 122 4
ZAP70 104 22
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 79 8
ASK1 101 11
Aurora A 81 2
Aurora B 60 1
BRSK1 81 1
BRSK2 80 3
BTK 71 6
CAMK1 92 11
CAMKK beta 44 1
CDK2-Cyclin A 97 7
CHK1 75 2
CHK2 78 6
CK1 delta
10
 1
CK2 94 12
CLK2
6
 2
CSK 87 4
DAPK1 79 6
DYRK1A 28 4
DYRK2 70 2
DYRK3 44 2
EF2K 101 7
EPH-A2 109 6
EPH-A4 97 2
EPH-B1 106 7
EPH-B2 92 11
EPH-B3 86 9
EPH-B4 112 5
ERK1 89 3
ERK2 93 11
ERK8 84 8
FGF-R1 81 1
GCK 32 2
GSK3 beta 59 4
HER4 106 12
HIPK1 94 6
HIPK2 83 1
HIPK3 98 2
IGF-1R 103 3
IKK beta 111 6
IKK epsilon 90 2
IR 103 4
IRAK4
2
 1
IRR 47 0
JAK2 89 1
JNK1 103 2
JNK2 96 1
JNK3 77 0
Lck 76 2
LKB1 94 7
MAPKAP-K2 99 8
MAPKAP-K3 83 5
MARK1 77 1
MARK2 74 3
MARK3 84 4
MARK4 69 2
MEKK1 61 3
MELK 80 9
MINK1 14 3
MKK1 79 3
MKK2 83 8
MKK6 88 5
MLK1 47 0
MLK3 30 4
MNK1 97 10
MNK2 104 3
MSK1 73 3
MST2 87 2
MST4 71 0
NEK2a 76 9
NEK6 77 1
NUAK1 62 9
p38 alpha MAPK 83 5
p38 beta MAPK 81 9
p38 delta MAPK 93 11
p38 gamma MAPK 85 5
PAK2 121 14
PAK4 66 3
PAK5 87 1
PAK6 87 5
PDK1 86 4
PHK 35 1
PIM1 69 1
PIM2 74 3
PIM3 73 2
PKA 93 1
PKB alpha 93 4
PKB beta 74 10
PKC alpha 94 8
PKC zeta 98 15
PKD1 96 3
PLK1 92 3
PRAK 88 6
PRK2 92 2
RIPK2 88 1
ROCK 2 85 14
RSK1 66 1
RSK2 73 5
S6K1 81 6
SGK1 92 5
SmMLCK 69 2
Src 98 5
SRPK1 44 3
SYK 96 1
TAK1 17 4
TAO1 85 3
TBK1 87 13
TrkA 27 3
TTK 55 8
VEGFR1 35 7
YES1 96 6