Protein transformations that change lives

Inhibitor | IRAK-4 kinase inhibitor a

Compound name	Brutto	MW	CAS	PubChem CID	Action	Reference	Reference
IRAK-4 kinase inhibitor a	C₂₂H₂₄N₄O₆	440.45			IRAK4	Wang Z. (2006) Structure 14 1835-1844

Screen Conc: 0.10µM
Kinase	% Activity Remaining	Standard Deviation
ABL	102	7
AMPK	91	8
ASK1	91	9
Aurora A	101	8
Aurora B	70	16
BRK	95	19
BRSK1	91	13
BRSK2	98	5
BTK	97	9
CAMK1	118	20
CAMKK beta	90	0
CDK2-Cyclin A	92	6
CHK1	90	15
CHK2	93	5
CK1 delta	78	6
CK2	65	7
CLK2	49	2
CSK	86	6
DAPK1	87	7
DYRK1A	91	4
DYRK2	96	7
DYRK3	95	3
EF2K	78	13
EIF2AK3	94	0
EPH-A2	93	4
EPH-A4	96	4
EPH-B1	111	13
EPH-B2	117	9
EPH-B3	84	6
EPH-B4	91	3
ERK1	90	7
ERK2	96	18
ERK8	69	1
FGF-R1	108	1
GCK	85	12
GSK3 beta	84	6
HER4	99	5
HIPK1	93	8
HIPK2	91	22
HIPK3	77	7
IGF-1R	88	16
IKK beta	96	4
IKK epsilon	94	10
IR	91	0
IRAK1	15	2
IRAK4	6	4
IRR	68	0
JAK2	87	9
JNK1	97	2
JNK2	86	3
JNK3	95	6
Lck	95	19
LKB1	86	4
MAPKAP-K2	104	6
MAPKAP-K3	87	7
MARK1	90	8
MARK2	87	8
MARK3	91	2
MARK4	84	9
MEKK1	96	0
MELK	93	3
MINK1	66	0
MKK1	83	23
MKK2	67	17
MKK6	126	9
MLK1	93	5
MLK3	87	5
MNK1	93	7
MNK2	93	4
MPSK1	87	19
MSK1	100	17
MST2	88	14
MST4	97	20
NEK2a	85	11
NEK6	83	9
NUAK1	85	4
OSR1	100	8
p38 alpha MAPK	89	22
p38 beta MAPK	95	15
p38 delta MAPK	86	15
p38 gamma MAPK	90	5
PAK2	87	11
PAK4	94	10
PAK5	89	6
PAK6	107	3
PDK1	93	7
PHK	94	7
PIM1	97	10
PIM2	87	0
PIM3	92	1
PKA	91	9
PKB alpha	102	7
PKB beta	95	13
PKC alpha	106	18
PKC gamma	105	0
PKC zeta	114	16
PKD1	76	13
PLK1	94	0
PRAK	110	18
PRK2	95	7
RIPK2	93	21
ROCK 2	92	12
RSK1	94	3
RSK2	96	5
S6K1	93	35
SGK1	89	8
SmMLCK	98	1
Src	111	21
SRPK1	93	9
STK33	82	3
SYK	89	23
TAK1	55	15
TAO1	99	9
TBK1	84	6
TESK1	97	9
TIE2	90	5
TLK1	96	10
TrkA	91	15
TSSK1	96	10
TTBK1	96	11
TTK	87	12
VEGFR1	93	1
YES1	90	2
ZAP70	99	2

Screen Conc: 1.00µM
Kinase	% Activity Remaining	Standard Deviation
ABL	105	8
AMPK	101	17
ASK1	90	7
Aurora A	101	16
Aurora B	80	4
BRK	107	0
BRSK1	106	14
BRSK2	89	9
BTK	94	16
CAMK1	134	7
CAMKK beta	98	1
CDK2-Cyclin A	89	7
CHK1	95	2
CHK2	102	12
CK1 delta	72	2
CK2	81	12
CLK2	50	13
CSK	88	7
DAPK1	87	9
DYRK1A	54	2
DYRK2	106	17
DYRK3	86	1
EF2K	94	4
EIF2AK3	99	9
EPH-A2	93	7
EPH-A4	103	1
EPH-B1	118	3
EPH-B2	110	7
EPH-B3	99	25
EPH-B4	102	4
ERK1	98	11
ERK2	104	8
ERK8	83	21
FGF-R1	111	16
GCK	92	13
GSK3 beta	95	6
HER4	100	15
HIPK1	106	24
HIPK2	87	11
HIPK3	90	16
IGF-1R	88	2
IKK beta	87	0
IKK epsilon	113	11
IR	91	5
IRAK1	11	3
IRAK4	6	0
IRR	69	10
JAK2	91	3
JNK1	103	2
JNK2	93	4
JNK3	95	7
Lck	92	11
LKB1	93	9
MAPKAP-K2	121	6
MAPKAP-K3	91	1
MARK1	100	3
MARK2	95	14
MARK3	93	10
MARK4	86	5
MEKK1	101	13
MELK	98	5
MINK1	30	2
MKK1	92	1
MKK2	77	15
MKK6	138	63
MLK1	99	5
MLK3	81	5
MNK1	107	0
MNK2	104	2
MPSK1	91	17
MSK1	99	5
MST2	102	7
MST4	109	10
NEK2a	90	0
NEK6	92	15
NUAK1	86	18
OSR1	94	10
p38 alpha MAPK	94	2
p38 beta MAPK	103	2
p38 delta MAPK	100	8
p38 gamma MAPK	107	18
PAK2	98	7
PAK4	91	0
PAK5	94	11
PAK6	104	13
PDK1	103	13
PHK	62	6
PIM1	101	6
PIM2	90	1
PIM3	98	6
PKA	94	5
PKB alpha	108	3
PKB beta	79	2
PKC alpha	119	6
PKC gamma	104	7
PKC zeta	107	3
PKD1	82	1
PLK1	107	5
PRAK	103	9
PRK2	104	14
RIPK2	96	13
ROCK 2	97	7
RSK1	98	11
RSK2	80	20
S6K1	100	5
SGK1	91	2
SmMLCK	81	20
Src	93	15
SRPK1	90	13
STK33	84	4
SYK	97	18
TAK1	71	11
TAO1	100	26
TBK1	97	9
TESK1	110	8
TIE2	108	9
TLK1	106	11
TrkA	99	14
TSSK1	106	21
TTBK1	87	14
TTK	91	8
VEGFR1	83	9
YES1	122	4
ZAP70	104	22

Screen Conc: 10.00µM
Kinase	% Activity Remaining	Standard Deviation
AMPK	79	8
ASK1	101	11
Aurora A	81	2
Aurora B	60	1
BRSK1	81	1
BRSK2	80	3
BTK	71	6
CAMK1	92	11
CAMKK beta	44	1
CDK2-Cyclin A	97	7
CHK1	75	2
CHK2	78	6
CK1 delta	10	1
CK2	94	12
CLK2	6	2
CSK	87	4
DAPK1	79	6
DYRK1A	28	4
DYRK2	70	2
DYRK3	44	2
EF2K	101	7
EPH-A2	109	6
EPH-A4	97	2
EPH-B1	106	7
EPH-B2	92	11
EPH-B3	86	9
EPH-B4	112	5
ERK1	89	3
ERK2	93	11
ERK8	84	8
FGF-R1	81	1
GCK	32	2
GSK3 beta	59	4
HER4	106	12
HIPK1	94	6
HIPK2	83	1
HIPK3	98	2
IGF-1R	103	3
IKK beta	111	6
IKK epsilon	90	2
IR	103	4
IRAK4	2	1
IRR	47	0
JAK2	89	1
JNK1	103	2
JNK2	96	1
JNK3	77	0
Lck	76	2
LKB1	94	7
MAPKAP-K2	99	8
MAPKAP-K3	83	5
MARK1	77	1
MARK2	74	3
MARK3	84	4
MARK4	69	2
MEKK1	61	3
MELK	80	9
MINK1	14	3
MKK1	79	3
MKK2	83	8
MKK6	88	5
MLK1	47	0
MLK3	30	4
MNK1	97	10
MNK2	104	3
MSK1	73	3
MST2	87	2
MST4	71	0
NEK2a	76	9
NEK6	77	1
NUAK1	62	9
p38 alpha MAPK	83	5
p38 beta MAPK	81	9
p38 delta MAPK	93	11
p38 gamma MAPK	85	5
PAK2	121	14
PAK4	66	3
PAK5	87	1
PAK6	87	5
PDK1	86	4
PHK	35	1
PIM1	69	1
PIM2	74	3
PIM3	73	2
PKA	93	1
PKB alpha	93	4
PKB beta	74	10
PKC alpha	94	8
PKC zeta	98	15
PKD1	96	3
PLK1	92	3
PRAK	88	6
PRK2	92	2
RIPK2	88	1
ROCK 2	85	14
RSK1	66	1
RSK2	73	5
S6K1	81	6
SGK1	92	5
SmMLCK	69	2
Src	98	5
SRPK1	44	3
SYK	96	1
TAK1	17	4
TAO1	85	3
TBK1	87	13
TrkA	27	3
TTK	55	8
VEGFR1	35	7
YES1	96	6