Inhibitor | IKK-2 Inhibitor IV (TPCA-1)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 507475-17-4 9903786 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373 Karin M. (2004) Nat. Rev. Drug Discov. 3 17

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
YES1 15 1
VEGFR1
4
 0
TTK 64 4
TrkA 26 3
TBK1 38 8
TAO1 21 2
TAK1
5
 2
SYK 38 2
SRPK1 76 4
Src 14 3
SmMLCK 42 3
SGK1 91 2
S6K1 81 4
RSK2 36 1
RSK1 23 4
ROCK 2 56 4
RIPK2 29 1
PRK2 41 7
PRAK 77 1
PLK1 77 2
PKD1 46 0
PKC zeta 94 12
PKC alpha 44 3
PKB beta 60 10
PKB alpha 85 4
PKA 85 6
PIM3 38 2
PIM2 37 1
PIM1 40 5
PHK 31 2
PDK1 34 3
PAK6 49 4
PAK5 40 8
PAK4 33 2
PAK2 72 5
p38 gamma MAPK 59 13
p38 delta MAPK 85 7
p38 beta MAPK 65 8
p38 alpha MAPK 81 3
NUAK1
8
 1
NEK6 98 8
NEK2a 65 2
MST4 19 2
MST2 12 0
MSK1 80 4
MNK2 58 3
MNK1 56 11
MLK3
2
 0
MLK1
4
 1
MKK6 62 7
MKK2 13 1
MKK1 23 2
MINK1 13 1
MELK 45 1
MEKK1 17 4
MARK4 57 6
MARK3 45 1
MARK2 52 12
MARK1 44 3
MAPKAP-K3 74 1
MAPKAP-K2 85 1
LKB1 32 0
Lck 36 3
JNK3 65 1
JNK2 83 1
JNK1 83 4
JAK2
9
 3
IRR 57 6
IRAK4 13 1
IR 46 5
IKK epsilon 30 1
IKK beta
8
 0
IGF-1R
9
 2
HIPK3 81 6
HIPK2 49 15
HIPK1 87 7
HER4 22 2
GSK3 beta 47 2
GCK
8
 0
FGF-R1 17 1
ERK8 25 1
ERK2 68 9
ERK1 62 5
EPH-B4 34 1
EPH-B3 12 5
EPH-B2 18 1
EPH-B1 17 1
EPH-A4 21 1
EPH-A2 31 0
EF2K 54 8
DYRK3 73 2
DYRK2 50 3
DYRK1A 65 5
DAPK1 21 0
CSK 90 9
CLK2 35 1
CK2 67 0
CK1 delta 81 7
CHK2 17 10
CHK1 39 2
CDK2-Cyclin A
8
 2
CAMKK beta 77 2
CAMK1 35 9
BTK
10
 0
BRSK2 42 4
BRSK1 27 2
Aurora B
5
 1
Aurora A 11 1
ASK1 14 1
AMPK 26 1
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
YES1 57 11
VEGFR1 23 0
TTK 94 3
TrkA 32 1
TBK1 75 0
TAO1 71 4
TAK1 21 0
SYK 91 3
SRPK1 92 8
Src 39 2
SmMLCK 104 7
SGK1 108 6
S6K1 102 1
RSK2 76 5
RSK1 77 3
ROCK 2 80 3
RIPK2 90 4
PRK2 71 4
PRAK 100 7
PLK1 91 0
PKD1 86 5
PKC zeta 102 3
PKC alpha 81 1
PKB beta 90 15
PKB alpha 97 7
PKA 98 3
PIM3 78 6
PIM2 104 8
PIM1 85 4
PHK 90 3
PDK1 87 0
PAK6 90 0
PAK5 88 8
PAK4 74 2
PAK2 97 13
p38 gamma MAPK 92 4
p38 delta MAPK 122 11
p38 beta MAPK 96 4
p38 alpha MAPK 101 9
NUAK1 31 1
NEK6 108 3
NEK2a 94 8
MST4 79 0
MST2 50 7
MSK1 97 0
MNK2 105 5
MNK1 100 3
MLK3 19 0
MLK1 21 0
MKK6 89 8
MKK2 54 0
MKK1 74 1
MINK1 69 12
MELK 89 2
MEKK1 61 6
MARK4 91 7
MARK3 81 2
MARK2 76 10
MARK1 98 10
MAPKAP-K3 94 10
MAPKAP-K2 98 9
LKB1 71 0
Lck 80 2
JNK3 93 2
JNK2 106 4
JNK1 93 8
JAK2 11 1
IRR 96 7
IRAK4 61 0
IR 94 14
IKK epsilon 86 3
IKK beta 15 0
IGF-1R 64 14
HIPK3 100 12
HIPK2 101 5
HIPK1 109 0
HER4 70 11
GSK3 beta 87 1
GCK 48 1
FGF-R1 61 3
ERK8 83 2
ERK2 102 11
ERK1 107 10
EPH-B4 85 8
EPH-B3 37 2
EPH-B2 83 10
EPH-B1 68 6
EPH-A4 73 10
EPH-A2 59 11
EF2K 103 6
DYRK3 101 4
DYRK2 100 8
DYRK1A 97 1
DAPK1 62 3
CSK 101 12
CLK2 84 5
CK2 109 8
CK1 delta 97 1
CHK2 51 8
CHK1 83 1
CDK2-Cyclin A 35 5
CAMKK beta 66 2
CAMK1 82 2
BTK 26 1
BRSK2 98 6
BRSK1 77 10
Aurora B 21 2
Aurora A 54 8
ASK1 62 1
AMPK 83 7