Inhibitor | IKK-2 Inhibitor IV (TPCA-1)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 507475-17-4 9903786 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373 Karin M. (2004) Nat. Rev. Drug Discov. 3 17

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
MLK3
2
 0
VEGFR1
4
 0
MLK1
4
 1
TAK1
5
 2
Aurora B
5
 1
NUAK1
8
 1
GCK
8
 0
IKK beta
8
 0
CDK2-Cyclin A
8
 2
IGF-1R
9
 2
JAK2
9
 3
BTK
10
 0
Aurora A 11 1
MST2 12 0
EPH-B3 12 5
MKK2 13 1
IRAK4 13 1
MINK1 13 1
ASK1 14 1
Src 14 3
YES1 15 1
CHK2 17 10
EPH-B1 17 1
MEKK1 17 4
FGF-R1 17 1
EPH-B2 18 1
MST4 19 2
DAPK1 21 0
EPH-A4 21 1
TAO1 21 2
HER4 22 2
MKK1 23 2
RSK1 23 4
ERK8 25 1
AMPK 26 1
TrkA 26 3
BRSK1 27 2
RIPK2 29 1
IKK epsilon 30 1
EPH-A2 31 0
PHK 31 2
LKB1 32 0
PAK4 33 2
PDK1 34 3
EPH-B4 34 1
CLK2 35 1
CAMK1 35 9
RSK2 36 1
Lck 36 3
PIM2 37 1
PIM3 38 2
SYK 38 2
TBK1 38 8
CHK1 39 2
PAK5 40 8
PIM1 40 5
PRK2 41 7
SmMLCK 42 3
BRSK2 42 4
MARK1 44 3
PKC alpha 44 3
MELK 45 1
MARK3 45 1
IR 46 5
PKD1 46 0
GSK3 beta 47 2
PAK6 49 4
HIPK2 49 15
DYRK2 50 3
MARK2 52 12
EF2K 54 8
MNK1 56 11
ROCK 2 56 4
IRR 57 6
MARK4 57 6
MNK2 58 3
p38 gamma MAPK 59 13
PKB beta 60 10
MKK6 62 7
ERK1 62 5
TTK 64 4
NEK2a 65 2
JNK3 65 1
DYRK1A 65 5
p38 beta MAPK 65 8
CK2 67 0
ERK2 68 9
PAK2 72 5
DYRK3 73 2
MAPKAP-K3 74 1
SRPK1 76 4
PRAK 77 1
CAMKK beta 77 2
PLK1 77 2
MSK1 80 4
S6K1 81 4
CK1 delta 81 7
HIPK3 81 6
p38 alpha MAPK 81 3
JNK1 83 4
JNK2 83 1
p38 delta MAPK 85 7
PKA 85 6
MAPKAP-K2 85 1
PKB alpha 85 4
HIPK1 87 7
CSK 90 9
SGK1 91 2
PKC zeta 94 12
NEK6 98 8
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
JAK2 11 1
IKK beta 15 0
MLK3 19 0
MLK1 21 0
TAK1 21 0
Aurora B 21 2
VEGFR1 23 0
BTK 26 1
NUAK1 31 1
TrkA 32 1
CDK2-Cyclin A 35 5
EPH-B3 37 2
Src 39 2
GCK 48 1
MST2 50 7
CHK2 51 8
MKK2 54 0
Aurora A 54 8
YES1 57 11
EPH-A2 59 11
MEKK1 61 6
IRAK4 61 0
FGF-R1 61 3
ASK1 62 1
DAPK1 62 3
IGF-1R 64 14
CAMKK beta 66 2
EPH-B1 68 6
MINK1 69 12
HER4 70 11
LKB1 71 0
PRK2 71 4
TAO1 71 4
EPH-A4 73 10
MKK1 74 1
PAK4 74 2
TBK1 75 0
MARK2 76 10
RSK2 76 5
RSK1 77 3
BRSK1 77 10
PIM3 78 6
MST4 79 0
ROCK 2 80 3
Lck 80 2
PKC alpha 81 1
MARK3 81 2
CAMK1 82 2
ERK8 83 2
EPH-B2 83 10
CHK1 83 1
AMPK 83 7
CLK2 84 5
PIM1 85 4
EPH-B4 85 8
PKD1 86 5
IKK epsilon 86 3
GSK3 beta 87 1
PDK1 87 0
PAK5 88 8
MKK6 89 8
MELK 89 2
PHK 90 3
RIPK2 90 4
PAK6 90 0
PKB beta 90 15
SYK 91 3
MARK4 91 7
PLK1 91 0
p38 gamma MAPK 92 4
SRPK1 92 8
JNK1 93 8
JNK3 93 2
NEK2a 94 8
TTK 94 3
IR 94 14
MAPKAP-K3 94 10
p38 beta MAPK 96 4
IRR 96 7
CK1 delta 97 1
DYRK1A 97 1
PAK2 97 13
MSK1 97 0
PKB alpha 97 7
MARK1 98 10
PKA 98 3
BRSK2 98 6
MAPKAP-K2 98 9
HIPK3 100 12
DYRK2 100 8
MNK1 100 3
PRAK 100 7
HIPK2 101 5
DYRK3 101 4
p38 alpha MAPK 101 9
CSK 101 12
S6K1 102 1
ERK2 102 11
PKC zeta 102 3
EF2K 103 6
SmMLCK 104 7
PIM2 104 8
MNK2 105 5
JNK2 106 4
ERK1 107 10
NEK6 108 3
SGK1 108 6
CK2 109 8
HIPK1 109 0
p38 delta MAPK 122 11