Inhibitor | A-443654  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
A-443654   C24H23ON5x2HCl 470.39 552325-16-3 10172943 Akt1 Shi Y. (2005) Neoplasia 7 992-1000.

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
SRPK1 91 2
Src 86 5
SmMLCK 27 2
SGK1 53 5
S6K1 32 9
RSK2 27 3
RSK1 32 1
ROCK 2
8
 1
PRK2
2
 2
PRAK 107 4
PLK1 80 1
PKD1 23 4
PKC zeta 66 0
PKC alpha 29 4
PKB beta
2
 0
PKB alpha
3
 2
PKA
3
 1
PIM3 13 1
PIM2 15 2
PIM1 15 2
PHK 54 6
PDK1 79 8
PAK6 87 3
PAK5 96 1
PAK4 90 6
p38 gamma MAPK 83 4
p38 delta MAPK 68 9
p38 beta MAPK 105 4
p38 alpha MAPK 92 6
NEK7 84 1
NEK6 95 4
NEK2a 95 2
MST2 29 0
MSK1
9
 2
MNK2 80 5
MNK1 109 2
MKK1 67 6
MELK 63 2
MARK3 83 1
MAPKAP-K3 96 2
MAPKAP-K2 73 0
Lck 97 3
JNK3 86 8
JNK2 78 9
JNK1 90 3
IKK beta 89 2
HIPK3 71 2
HIPK2 24 3
GSK3 beta 33 4
ERK8 28 3
ERK2 64 2
ERK1 59 3
EF2K 94 8
DYRK3
8
 1
DYRK2 26 1
DYRK1A
7
 3
CSK 93 7
CK2 90 8
CK1 delta 74 3
CHK2 95 2
CHK1 99 2
CDK2-Cyclin A 31 2
CAMKK beta 63 9
CAMKK alpha 117 1
CAMK1 77 6
BRSK2 79 1
Aurora C 92 8
Aurora B 80 2
AMPK 67 3
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
SRPK1 92 8
Src 91 0
SmMLCK 69 2
SGK1 78 2
S6K1 88 3
RSK2 74 3
RSK1 78 1
ROCK 2 48 3
PRK2 17 2
PRAK 107 3
PLK1 89 5
PKD1 63 3
PKC zeta 82 3
PKC alpha 73 3
PKB beta 17 2
PKB alpha
5
 2
PKA 26 1
PIM3 54 6
PIM2 59 0
PIM1 57 8
PHK 86 7
PDK1 88 1
PAK6 87 2
PAK5 104 2
PAK4 99 3
p38 gamma MAPK 87 5
p38 delta MAPK 86 1
p38 beta MAPK 114 3
p38 alpha MAPK 131 2
NEK7 86 8
NEK6 95 2
NEK2a 101 5
MST2 76 4
MSK1 19 2
MNK2 97 2
MNK1 120 3
MKK1 84 2
MELK 96 2
MARK3 100 3
MAPKAP-K3 91 9
MAPKAP-K2 92 8
Lck 97 8
JNK3 81 9
JNK2 94 1
JNK1 89 7
IKK beta 93 8
HIPK3 90 0
HIPK2 73 2
GSK3 beta 81 1
ERK8 61 2
ERK2 78 6
ERK1 77 8
EF2K 93 7
DYRK3 41 3
DYRK2 79 5
DYRK1A
10
 2
CSK 99 2
CK2 96 0
CK1 delta 95 3
CHK2 94 8
CHK1 100 3
CDK2-Cyclin A 82 5
CAMKK beta 83 8
CAMKK alpha 112 2
CAMK1 89 3
BRSK2 88 9
Aurora C 100 4
Aurora B 81 3
AMPK 84 8