Inhibitor | A-443654  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
A-443654   C24H23ON5x2HCl 470.39 552325-16-3 10172943 Akt1 Shi Y. (2005) Neoplasia 7 992-1000.

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
p38 alpha MAPK 131 2
MNK1 120 3
p38 beta MAPK 114 3
CAMKK alpha 112 2
PRAK 107 3
PAK5 104 2
NEK2a 101 5
CHK1 100 3
Aurora C 100 4
MARK3 100 3
PAK4 99 3
CSK 99 2
Lck 97 8
MNK2 97 2
MELK 96 2
CK2 96 0
CK1 delta 95 3
NEK6 95 2
JNK2 94 1
CHK2 94 8
IKK beta 93 8
EF2K 93 7
SRPK1 92 8
MAPKAP-K2 92 8
Src 91 0
MAPKAP-K3 91 9
HIPK3 90 0
CAMK1 89 3
JNK1 89 7
PLK1 89 5
PDK1 88 1
S6K1 88 3
BRSK2 88 9
PAK6 87 2
p38 gamma MAPK 87 5
PHK 86 7
NEK7 86 8
p38 delta MAPK 86 1
MKK1 84 2
AMPK 84 8
CAMKK beta 83 8
PKC zeta 82 3
CDK2-Cyclin A 82 5
JNK3 81 9
GSK3 beta 81 1
Aurora B 81 3
DYRK2 79 5
SGK1 78 2
ERK2 78 6
RSK1 78 1
ERK1 77 8
MST2 76 4
RSK2 74 3
HIPK2 73 2
PKC alpha 73 3
SmMLCK 69 2
PKD1 63 3
ERK8 61 2
PIM2 59 0
PIM1 57 8
PIM3 54 6
ROCK 2 48 3
DYRK3 41 3
PKA 26 1
MSK1 19 2
PKB beta 17 2
PRK2 17 2
DYRK1A
10
 2
PKB alpha
5
 2
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
CAMKK alpha 117 1
MNK1 109 2
PRAK 107 4
p38 beta MAPK 105 4
CHK1 99 2
Lck 97 3
MAPKAP-K3 96 2
PAK5 96 1
NEK2a 95 2
CHK2 95 2
NEK6 95 4
EF2K 94 8
CSK 93 7
Aurora C 92 8
p38 alpha MAPK 92 6
SRPK1 91 2
CK2 90 8
PAK4 90 6
JNK1 90 3
IKK beta 89 2
PAK6 87 3
Src 86 5
JNK3 86 8
NEK7 84 1
p38 gamma MAPK 83 4
MARK3 83 1
Aurora B 80 2
MNK2 80 5
PLK1 80 1
BRSK2 79 1
PDK1 79 8
JNK2 78 9
CAMK1 77 6
CK1 delta 74 3
MAPKAP-K2 73 0
HIPK3 71 2
p38 delta MAPK 68 9
AMPK 67 3
MKK1 67 6
PKC zeta 66 0
ERK2 64 2
MELK 63 2
CAMKK beta 63 9
ERK1 59 3
PHK 54 6
SGK1 53 5
GSK3 beta 33 4
RSK1 32 1
S6K1 32 9
CDK2-Cyclin A 31 2
MST2 29 0
PKC alpha 29 4
ERK8 28 3
RSK2 27 3
SmMLCK 27 2
DYRK2 26 1
HIPK2 24 3
PKD1 23 4
PIM2 15 2
PIM1 15 2
PIM3 13 1
MSK1
9
 2
DYRK3
8
 1
ROCK 2
8
 1
DYRK1A
7
 3
PKB alpha
3
 2
PKA
3
 1
PKB beta
2
 0
PRK2
2
 2