Inhibitor |
HA-1077, Dihydrochloride (Fasudil)
Screening Results Tables
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining
Sort descending
|
Standard Deviation |
|
ROCK 2
|
12
|
3
|
|
ERK8
|
14
|
1
|
|
RSK1
|
16
|
0
|
|
PRK2
|
17
|
2
|
|
MSK1
|
20
|
2
|
|
PKA
|
26
|
2
|
|
NUAK1
|
27
|
2
|
|
S6K1
|
33
|
7
|
|
DYRK3
|
36
|
4
|
|
PKD1
|
44
|
2
|
|
RSK2
|
44
|
1
|
|
CHK2
|
47
|
3
|
|
TAK1
|
47
|
6
|
|
CLK2
|
51
|
2
|
|
MNK1
|
52
|
6
|
|
MELK
|
54
|
6
|
|
PKB alpha
|
55
|
1
|
|
MNK2
|
55
|
2
|
|
BRSK1
|
55
|
2
|
|
DAPK1
|
55
|
5
|
|
MEKK1
|
57
|
5
|
|
BRSK2
|
58
|
2
|
|
VEGFR1
|
60
|
6
|
|
PHK
|
61
|
2
|
|
LKB1
|
62
|
1
|
|
MKK2
|
63
|
2
|
|
SmMLCK
|
64
|
2
|
|
MLK3
|
65
|
6
|
|
FGF-R1
|
66
|
2
|
|
MST2
|
69
|
5
|
|
Aurora B
|
70
|
2
|
|
MKK1
|
72
|
1
|
|
AMPK
|
73
|
6
|
|
GCK
|
74
|
2
|
|
MAPKAP-K2
|
75
|
6
|
|
PKC alpha
|
77
|
2
|
|
MINK1
|
77
|
8
|
|
CAMKK beta
|
79
|
9
|
|
GSK3 beta
|
80
|
4
|
|
MLK1
|
81
|
2
|
|
JNK3
|
81
|
2
|
|
IRAK4
|
82
|
2
|
|
PAK5
|
83
|
13
|
|
EPH-B3
|
83
|
6
|
|
MARK3
|
83
|
1
|
|
JAK2
|
83
|
0
|
|
CK1 delta
|
84
|
1
|
|
p38 alpha MAPK
|
84
|
8
|
|
ERK2
|
84
|
15
|
|
DYRK2
|
84
|
6
|
|
p38 delta MAPK
|
84
|
9
|
|
TAO1
|
85
|
5
|
|
PIM3
|
85
|
7
|
|
PKC zeta
|
85
|
10
|
|
MARK1
|
87
|
3
|
|
MAPKAP-K3
|
87
|
6
|
|
PAK6
|
88
|
3
|
|
DYRK1A
|
88
|
2
|
|
SYK
|
88
|
7
|
|
TTK
|
88
|
0
|
|
SGK1
|
89
|
1
|
|
PKB beta
|
89
|
5
|
|
HIPK3
|
89
|
10
|
|
PIM1
|
89
|
2
|
|
CHK1
|
91
|
6
|
|
MKK6
|
91
|
5
|
|
TBK1
|
91
|
1
|
|
CAMK1
|
91
|
3
|
|
NEK2a
|
91
|
7
|
|
IRR
|
92
|
1
|
|
ERK1
|
92
|
1
|
|
IKK epsilon
|
92
|
2
|
|
Aurora A
|
92
|
7
|
|
PAK4
|
93
|
3
|
|
Src
|
93
|
0
|
|
MARK2
|
93
|
4
|
|
ASK1
|
93
|
11
|
|
RIPK2
|
93
|
6
|
|
HER4
|
93
|
9
|
|
PDK1
|
93
|
2
|
|
IKK beta
|
94
|
13
|
|
JNK1
|
94
|
0
|
|
YES1
|
94
|
1
|
|
BTK
|
94
|
0
|
|
EPH-A2
|
94
|
6
|
|
EF2K
|
95
|
4
|
|
HIPK1
|
96
|
5
|
|
EPH-B1
|
96
|
6
|
|
MST4
|
96
|
4
|
|
EPH-B4
|
96
|
7
|
|
MARK4
|
96
|
3
|
|
Lck
|
97
|
5
|
|
CSK
|
97
|
1
|
|
EPH-B2
|
97
|
5
|
|
PRAK
|
98
|
12
|
|
HIPK2
|
99
|
4
|
|
PAK2
|
99
|
2
|
|
EPH-A4
|
100
|
4
|
|
NEK6
|
100
|
3
|
|
PLK1
|
101
|
2
|
|
PIM2
|
101
|
1
|
|
SRPK1
|
103
|
0
|
|
IR
|
104
|
2
|
|
JNK2
|
104
|
8
|
|
CDK2-Cyclin A
|
104
|
1
|
|
p38 gamma MAPK
|
104
|
8
|
|
CK2
|
105
|
1
|
|
IGF-1R
|
107
|
1
|
|
p38 beta MAPK
|
111
|
6
|
|
TrkA
|
118
|
15
|
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining
Sort descending
|
Standard Deviation |
|
ROCK 2
|
32
|
0
|
|
RSK1
|
52
|
6
|
|
ERK8
|
59
|
5
|
|
PRK2
|
62
|
3
|
|
MSK1
|
65
|
6
|
|
NUAK1
|
71
|
1
|
|
PKA
|
79
|
3
|
|
BRSK1
|
81
|
8
|
|
S6K1
|
81
|
1
|
|
NEK2a
|
81
|
3
|
|
DAPK1
|
81
|
1
|
|
MLK3
|
84
|
1
|
|
PAK4
|
84
|
8
|
|
p38 beta MAPK
|
86
|
5
|
|
PKD1
|
87
|
3
|
|
TAK1
|
88
|
5
|
|
JAK2
|
90
|
2
|
|
GSK3 beta
|
90
|
3
|
|
DYRK3
|
90
|
3
|
|
LKB1
|
91
|
12
|
|
MST4
|
92
|
3
|
|
RSK2
|
92
|
1
|
|
MKK1
|
92
|
9
|
|
JNK1
|
93
|
6
|
|
PIM3
|
94
|
3
|
|
MLK1
|
95
|
5
|
|
EPH-B3
|
95
|
11
|
|
HIPK3
|
95
|
3
|
|
CLK2
|
95
|
1
|
|
BTK
|
96
|
3
|
|
CHK2
|
96
|
9
|
|
PKC zeta
|
97
|
0
|
|
HIPK1
|
97
|
6
|
|
MEKK1
|
98
|
10
|
|
PKB alpha
|
98
|
8
|
|
CAMKK beta
|
98
|
1
|
|
DYRK1A
|
98
|
0
|
|
p38 alpha MAPK
|
98
|
2
|
|
SmMLCK
|
98
|
11
|
|
MKK2
|
99
|
2
|
|
IRAK4
|
99
|
4
|
|
MARK2
|
99
|
3
|
|
CDK2-Cyclin A
|
99
|
6
|
|
SGK1
|
99
|
4
|
|
TrkA
|
99
|
3
|
|
PIM2
|
100
|
6
|
|
CK1 delta
|
100
|
5
|
|
TTK
|
100
|
5
|
|
PKB beta
|
100
|
1
|
|
MARK3
|
101
|
2
|
|
JNK2
|
101
|
8
|
|
PHK
|
101
|
3
|
|
Aurora B
|
101
|
0
|
|
NEK6
|
102
|
11
|
|
IKK beta
|
102
|
3
|
|
PDK1
|
102
|
7
|
|
PAK2
|
102
|
1
|
|
RIPK2
|
102
|
8
|
|
Src
|
102
|
2
|
|
YES1
|
102
|
4
|
|
EPH-B1
|
103
|
4
|
|
HER4
|
103
|
10
|
|
MST2
|
104
|
5
|
|
MARK4
|
104
|
7
|
|
MNK1
|
104
|
10
|
|
EF2K
|
104
|
2
|
|
PAK5
|
104
|
11
|
|
GCK
|
105
|
5
|
|
TBK1
|
105
|
2
|
|
MINK1
|
105
|
9
|
|
BRSK2
|
105
|
2
|
|
MELK
|
105
|
1
|
|
JNK3
|
105
|
0
|
|
PIM1
|
106
|
13
|
|
MKK6
|
106
|
9
|
|
FGF-R1
|
106
|
7
|
|
VEGFR1
|
106
|
1
|
|
PKC alpha
|
107
|
3
|
|
ERK1
|
107
|
0
|
|
PRAK
|
107
|
1
|
|
Aurora A
|
107
|
13
|
|
CSK
|
107
|
11
|
|
PAK6
|
107
|
1
|
|
p38 delta MAPK
|
108
|
4
|
|
EPH-B4
|
108
|
9
|
|
IKK epsilon
|
109
|
11
|
|
MNK2
|
109
|
15
|
|
DYRK2
|
109
|
6
|
|
SRPK1
|
110
|
7
|
|
MAPKAP-K2
|
110
|
7
|
|
MAPKAP-K3
|
110
|
9
|
|
CK2
|
110
|
6
|
|
IGF-1R
|
110
|
6
|
|
IRR
|
110
|
6
|
|
AMPK
|
111
|
0
|
|
EPH-A2
|
111
|
1
|
|
PLK1
|
112
|
9
|
|
HIPK2
|
113
|
1
|
|
ERK2
|
114
|
5
|
|
CAMK1
|
115
|
1
|
|
p38 gamma MAPK
|
116
|
1
|
|
CHK1
|
117
|
4
|
|
EPH-A4
|
119
|
1
|
|
TAO1
|
120
|
3
|
|
SYK
|
121
|
4
|
|
IR
|
121
|
5
|
|
MARK1
|
124
|
15
|
|
ASK1
|
124
|
0
|
|
EPH-B2
|
127
|
14
|
|
Lck
|
127
|
8
|
