| Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
|---|---|---|---|---|---|---|---|
| Compound C (Dorsomorphin) | C24H25N5O | 399.50 | 1219168-18-9 | 11524144 | AMPK | Yu P.B. (2008) Nat. Chem. Biol. 4 33 | Kim E.K. (2004) J. Biol. Chem. 279 19970 |
| Kinase | % Activity Remaining Sort descending | Standard Deviation |
|---|---|---|
| CLK2 |
1
|
0 |
| DYRK1A |
2
|
0 |
| ERK8 |
2
|
1 |
| CK1 delta |
2
|
0 |
| PHK |
2
|
0 |
| MINK1 |
4
|
2 |
| EPH-B4 |
5
|
0 |
| DYRK3 |
5
|
0 |
| GCK |
5
|
2 |
| TAK1 |
5
|
2 |
| Lck |
5
|
0 |
| HIPK2 |
6
|
1 |
| EPH-B1 |
6
|
1 |
| RIPK2 |
7
|
2 |
| MLK3 |
7
|
0 |
| CDK2-Cyclin A |
8
|
1 |
| CK2 |
8
|
1 |
| YES1 |
8
|
3 |
| DYRK2 |
9
|
0 |
| EPH-A4 |
10
|
2 |
| EPH-B2 |
10
|
2 |
| EPH-B3 |
10
|
0 |
| FGF-R1 | 11 | 2 |
| TrkA | 11 | 5 |
| IRAK4 | 11 | 1 |
| PRK2 | 14 | 4 |
| Src | 14 | 1 |
| MSK1 | 15 | 1 |
| VEGFR1 | 15 | 0 |
| MELK | 16 | 0 |
| AMPK | 16 | 1 |
| Aurora B | 17 | 0 |
| NUAK1 | 17 | 3 |
| CSK | 17 | 1 |
| HIPK1 | 18 | 2 |
| ROCK 2 | 18 | 4 |
| MARK3 | 19 | 0 |
| MNK1 | 19 | 4 |
| TBK1 | 19 | 1 |
| IRR | 21 | 1 |
| GSK3 beta | 21 | 1 |
| CAMKK beta | 21 | 2 |
| IKK epsilon | 22 | 0 |
| IR | 22 | 3 |
| RSK1 | 22 | 2 |
| SGK1 | 23 | 3 |
| Aurora A | 23 | 4 |
| MLK1 | 25 | 6 |
| MNK2 | 25 | 5 |
| BRSK2 | 27 | 0 |
| S6K1 | 29 | 1 |
| HIPK3 | 29 | 2 |
| BTK | 30 | 8 |
| TTK | 32 | 3 |
| DAPK1 | 33 | 1 |
| PKB alpha | 35 | 2 |
| CHK2 | 36 | 6 |
| BRSK1 | 36 | 4 |
| SYK | 39 | 6 |
| EPH-A2 | 40 | 1 |
| PKB beta | 40 | 2 |
| PAK4 | 44 | 1 |
| PKA | 44 | 2 |
| MARK1 | 45 | 1 |
| CHK1 | 47 | 1 |
| PIM1 | 48 | 5 |
| RSK2 | 50 | 4 |
| p38 beta MAPK | 50 | 7 |
| PIM3 | 52 | 4 |
| PKC zeta | 53 | 4 |
| CAMK1 | 53 | 0 |
| IKK beta | 54 | 3 |
| PKD1 | 56 | 12 |
| JNK3 | 56 | 1 |
| SmMLCK | 56 | 6 |
| JAK2 | 57 | 0 |
| PAK5 | 57 | 2 |
| MKK1 | 57 | 2 |
| NEK2a | 60 | 6 |
| HER4 | 61 | 13 |
| TAO1 | 62 | 8 |
| MARK2 | 62 | 4 |
| MARK4 | 63 | 7 |
| PAK6 | 63 | 1 |
| p38 gamma MAPK | 67 | 12 |
| MST4 | 67 | 10 |
| MEKK1 | 67 | 9 |
| ERK2 | 71 | 2 |
| MKK2 | 71 | 12 |
| EF2K | 72 | 9 |
| PKC alpha | 75 | 4 |
| IGF-1R | 77 | 11 |
| PLK1 | 78 | 1 |
| PRAK | 78 | 10 |
| NEK6 | 82 | 3 |
| MST2 | 83 | 6 |
| p38 delta MAPK | 85 | 11 |
| LKB1 | 85 | 1 |
| PAK2 | 86 | 3 |
| MAPKAP-K3 | 86 | 15 |
| JNK2 | 87 | 7 |
| PDK1 | 88 | 7 |
| ASK1 | 89 | 2 |
| MAPKAP-K2 | 90 | 3 |
| PIM2 | 96 | 1 |
| MKK6 | 96 | 1 |
| SRPK1 | 98 | 3 |
| JNK1 | 101 | 1 |
| p38 alpha MAPK | 107 | 12 |
| ERK1 | 117 | 13 |
| Kinase | % Activity Remaining Sort descending | Standard Deviation |
|---|---|---|
| ERK8 |
8
|
1 |
| DYRK1A |
8
|
0 |
| RIPK2 |
9
|
1 |
| GCK |
9
|
2 |
| CLK2 |
9
|
1 |
| CK1 delta | 14 | 0 |
| PHK | 15 | 10 |
| VEGFR1 | 18 | 3 |
| YES1 | 18 | 0 |
| MINK1 | 20 | 0 |
| EPH-B2 | 21 | 3 |
| TAK1 | 21 | 0 |
| TrkA | 24 | 4 |
| Lck | 24 | 1 |
| EPH-B1 | 25 | 1 |
| CAMKK beta | 25 | 2 |
| EPH-B4 | 26 | 2 |
| AMPK | 27 | 1 |
| DYRK3 | 27 | 0 |
| MELK | 27 | 2 |
| HIPK2 | 32 | 3 |
| EPH-B3 | 32 | 3 |
| NUAK1 | 34 | 13 |
| FGF-R1 | 36 | 2 |
| Src | 37 | 1 |
| PRK2 | 40 | 5 |
| CDK2-Cyclin A | 40 | 4 |
| IR | 40 | 12 |
| MLK3 | 42 | 4 |
| IRAK4 | 44 | 2 |
| CK2 | 45 | 0 |
| IRR | 47 | 5 |
| DYRK2 | 47 | 0 |
| Aurora B | 51 | 8 |
| EPH-A4 | 52 | 2 |
| MLK1 | 53 | 2 |
| MNK1 | 56 | 4 |
| MNK2 | 56 | 1 |
| TBK1 | 61 | 7 |
| BTK | 61 | 12 |
| HIPK1 | 64 | 3 |
| GSK3 beta | 65 | 8 |
| EPH-A2 | 66 | 1 |
| IKK epsilon | 67 | 5 |
| MSK1 | 68 | 5 |
| CSK | 68 | 5 |
| IKK beta | 69 | 9 |
| S6K1 | 70 | 3 |
| MARK1 | 71 | 7 |
| MARK3 | 72 | 0 |
| MARK2 | 73 | 9 |
| MARK4 | 74 | 2 |
| RSK1 | 75 | 6 |
| CHK2 | 75 | 7 |
| PAK4 | 75 | 4 |
| ERK2 | 76 | 2 |
| EF2K | 77 | 3 |
| p38 beta MAPK | 78 | 3 |
| ROCK 2 | 80 | 1 |
| PKB beta | 81 | 11 |
| BRSK1 | 83 | 4 |
| TTK | 83 | 6 |
| LKB1 | 83 | 4 |
| SYK | 83 | 1 |
| SGK1 | 84 | 0 |
| PIM1 | 84 | 2 |
| MST2 | 85 | 4 |
| TAO1 | 85 | 3 |
| Aurora A | 87 | 6 |
| PKA | 87 | 2 |
| PKC zeta | 87 | 3 |
| DAPK1 | 88 | 5 |
| PLK1 | 89 | 6 |
| MKK2 | 92 | 11 |
| MAPKAP-K3 | 94 | 3 |
| JNK3 | 94 | 2 |
| PKB alpha | 94 | 1 |
| BRSK2 | 94 | 7 |
| HER4 | 94 | 4 |
| CAMK1 | 94 | 13 |
| JNK1 | 95 | 3 |
| PAK5 | 96 | 11 |
| PKC alpha | 96 | 9 |
| ASK1 | 96 | 7 |
| NEK2a | 97 | 1 |
| PKD1 | 97 | 15 |
| p38 alpha MAPK | 98 | 7 |
| HIPK3 | 99 | 3 |
| p38 delta MAPK | 99 | 13 |
| MEKK1 | 99 | 11 |
| MKK1 | 101 | 1 |
| NEK6 | 101 | 9 |
| p38 gamma MAPK | 102 | 0 |
| MKK6 | 103 | 2 |
| IGF-1R | 103 | 14 |
| RSK2 | 104 | 7 |
| PIM3 | 105 | 11 |
| ERK1 | 107 | 8 |
| CHK1 | 107 | 6 |
| JAK2 | 107 | 12 |
| PIM2 | 108 | 4 |
| SRPK1 | 108 | 3 |
| PAK6 | 110 | 14 |
| MST4 | 115 | 3 |
| MAPKAP-K2 | 115 | 8 |
| PRAK | 117 | 3 |
| PAK2 | 118 | 13 |
| SmMLCK | 120 | 4 |
| JNK2 | 120 | 9 |
| PDK1 | 122 | 6 |
| Kinase | % Activity Remaining Sort descending | Standard Deviation |
|---|---|---|
| VEGFR1 | 18 | 0 |
| RIPK2 | 23 | 2 |
| GCK | 29 | 4 |
| CLK2 | 38 | 0 |
| PHK | 43 | 3 |
| MELK | 43 | 0 |
| DYRK1A | 44 | 0 |
| NUAK1 | 45 | 4 |
| IR | 46 | 12 |
| CK1 delta | 47 | 1 |
| ERK8 | 49 | 1 |
| YES1 | 50 | 3 |
| TrkA | 51 | 2 |
| CAMKK beta | 56 | 0 |
| MINK1 | 62 | 7 |
| AMPK | 64 | 7 |
| IRR | 69 | 3 |
| EPH-B1 | 70 | 5 |
| MLK1 | 70 | 11 |
| GSK3 beta | 70 | 3 |
| TAK1 | 71 | 3 |
| CDK2-Cyclin A | 71 | 4 |
| Lck | 73 | 5 |
| DYRK3 | 74 | 0 |
| Src | 76 | 5 |
| LKB1 | 76 | 13 |
| EPH-B3 | 78 | 9 |
| IKK beta | 79 | 1 |
| MARK4 | 80 | 3 |
| EPH-B2 | 80 | 2 |
| S6K1 | 80 | 0 |
| MARK2 | 81 | 1 |
| EPH-B4 | 81 | 3 |
| EF2K | 81 | 1 |
| CSK | 83 | 6 |
| ERK2 | 84 | 10 |
| PRK2 | 85 | 12 |
| CK2 | 85 | 6 |
| TTK | 86 | 6 |
| PAK4 | 87 | 8 |
| PKA | 87 | 0 |
| ASK1 | 87 | 0 |
| ROCK 2 | 88 | 1 |
| DYRK2 | 88 | 0 |
| MKK1 | 88 | 6 |
| IKK epsilon | 88 | 5 |
| BTK | 89 | 3 |
| JNK3 | 89 | 12 |
| CHK2 | 89 | 4 |
| FGF-R1 | 90 | 5 |
| MAPKAP-K3 | 90 | 4 |
| PKB beta | 90 | 6 |
| NEK6 | 90 | 6 |
| MLK3 | 90 | 0 |
| PKC zeta | 91 | 13 |
| BRSK1 | 91 | 1 |
| RSK1 | 91 | 2 |
| MSK1 | 91 | 9 |
| EPH-A2 | 91 | 8 |
| MST2 | 92 | 7 |
| SYK | 92 | 6 |
| HIPK2 | 93 | 8 |
| MARK1 | 94 | 6 |
| PIM3 | 95 | 13 |
| p38 beta MAPK | 95 | 9 |
| JNK1 | 95 | 1 |
| PAK6 | 95 | 0 |
| p38 gamma MAPK | 96 | 5 |
| PKB alpha | 96 | 2 |
| HIPK3 | 96 | 2 |
| BRSK2 | 96 | 4 |
| Aurora B | 96 | 10 |
| MKK6 | 97 | 10 |
| IGF-1R | 98 | 6 |
| MAPKAP-K2 | 99 | 6 |
| JNK2 | 99 | 12 |
| MST4 | 99 | 6 |
| MARK3 | 99 | 3 |
| MNK1 | 99 | 4 |
| TBK1 | 100 | 12 |
| PIM1 | 100 | 7 |
| NEK2a | 100 | 8 |
| JAK2 | 100 | 3 |
| SGK1 | 100 | 2 |
| HIPK1 | 101 | 0 |
| PKD1 | 101 | 3 |
| CHK1 | 101 | 1 |
| MEKK1 | 101 | 6 |
| PDK1 | 102 | 3 |
| PRAK | 102 | 3 |
| SRPK1 | 102 | 5 |
| DAPK1 | 103 | 1 |
| IRAK4 | 103 | 13 |
| p38 alpha MAPK | 103 | 5 |
| TAO1 | 103 | 11 |
| p38 delta MAPK | 104 | 8 |
| HER4 | 104 | 9 |
| PKC alpha | 105 | 12 |
| PLK1 | 105 | 11 |
| PIM2 | 105 | 4 |
| SmMLCK | 106 | 9 |
| MKK2 | 106 | 1 |
| EPH-A4 | 108 | 13 |
| RSK2 | 108 | 6 |
| PAK5 | 108 | 4 |
| PAK2 | 111 | 12 |
| MNK2 | 112 | 3 |
| ERK1 | 117 | 11 |
| Aurora A | 117 | 3 |
| CAMK1 | 117 | 7 |