Inhibitor | Celastrol  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Celastrol   C29H38O4 450.60 34157-83-0 92310323 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

Screening Results Chart

Screening Results Tables

Screen Conc: 5.00µM
Kinase % Activity Remaining Standard Deviation
Aurora B 11 2
BRSK2 23 1
DYRK3 23 6
MLK3 30 5
ERK2 39 1
TSSK1 42 1
PRAK 45 8
VEGFR1 49 6
MAP4K3 50 14
PKC gamma 52 6
MARK4 57 2
ERK8 58 1
RSK2 60 7
FGF-R1 63 8
SIK3 64 2
MAPKAP-K3 64 1
TrkA 66 12
IKK epsilon 67 4
PLK1 68 18
SIK2 69 6
S6K1 70 5
MKK2 71 4
TTK 71 4
IKK beta 74 3
AMPK (hum) 74 6
PKD1 75 5
MARK1 76 6
HIPK3 77 13
NEK6 78 1
SGK1 80 3
PINK 81 8
BRSK1 81 0
PKB beta 82 3
JNK3 82 11
CHK2 82 1
MST4 82 6
CDK2-Cyclin A 83 5
IRR 83 6
TAK1 83 4
PAK5 83 3
NUAK1 84 3
RSK1 84 2
PRK2 85 4
PAK4 86 7
MKK1 88 1
DYRK2 88 23
MARK2 88 8
EPH-A2 88 17
MLK1 89 8
CSK 89 1
HIPK1 89 0
GCK 89 6
PDK1 89 1
Src 90 2
EPH-A4 90 10
TESK1 91 24
IR 91 4
PKB alpha 91 17
TTBK2 91 13
CLK2 91 1
MARK3 92 6
MELK 93 7
Aurora A 93 3
TLK1 94 5
LKB1 94 6
PAK2 94 1
MSK1 95 3
p38 beta MAPK 95 0
MST2 95 1
ERK5 96 11
SRPK1 96 5
CK1 gamma 2 96 3
DYRK1A 96 13
TGFBR1 97 9
DAPK1 97 1
STK33 97 1
WNK1 97 2
IRAK1 98 6
PIM3 98 6
ABL 98 8
TIE2 98 10
PIM1 99 1
YES1 99 7
EIF2AK3 99 2
PHK 100 4
JNK2 101 23
PKC alpha 102 0
CDK9-Cyclin T1 102 3
CAMK1 103 2
CK2 103 4
JAK2 103 1
PDGFRA 103 3
ROCK 2 103 9
ULK1 103 1
ULK2 104 16
MINK1 104 15
SmMLCK 104 5
Lck 104 10
p38 alpha MAPK 105 6
TAO1 106 12
BTK 106 11
HIPK2 106 4
JNK1 107 10
MNK2 107 10
p38 gamma MAPK 107 11
ERK1 107 3
MAP4K5 108 1
MEKK1 108 1
CAMKK beta 108 1
IGF-1R 110 17
DDR2 110 6
TTBK1 110 2
PIM2 111 14
EF2K 111 7
EPH-B3 112 28
MAPKAP-K2 113 2
PAK6 113 6
BRK 113 5
ZAP70 114 4
PKA 115 9
GSK3 beta 115 1
EPH-B2 116 24
TBK1 116 1
MNK1 117 2
NEK2a 118 8
p38 delta MAPK 119 0
MKK6 120 1
MPSK1 120 8
EPH-B4 121 10
RIPK2 121 4
MST3 122 2
CHK1 129 8
CK1 delta 130 43
SYK 131 6
ASK1 133 8
EPH-B1 133 33
OSR1 138 4
HER4 140 5
IRAK4 142 7
PKC zeta 174 7
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
TSSK1 60 6
ERK8 62 5
PKC gamma 63 12
PRAK 63 5
BRSK2 65 0
MLK3 66 3
Aurora B 67 7
DYRK2 71 10
p38 gamma MAPK 71 18
RSK2 72 8
GCK 73 1
TrkA 74 10
JNK3 76 2
VEGFR1 77 18
ZAP70 78 10
EPH-B1 78 1
FGF-R1 78 7
PKD1 79 1
CSK 79 0
p38 delta MAPK 80 6
SYK 81 19
TLK1 81 5
RSK1 81 2
ERK5 82 0
CAMKK beta 82 4
ROCK 2 83 5
TTK 83 3
LKB1 83 3
SmMLCK 83 5
CDK2-Cyclin A 84 1
SIK2 85 4
TAK1 85 7
MLK1 85 6
MARK2 86 6
CAMK1 86 8
ERK2 86 12
CDK9-Cyclin T1 87 17
EF2K 87 8
EIF2AK3 87 6
MELK 88 27
NEK6 88 6
SGK1 88 0
DAPK1 88 17
CK1 delta 88 7
DYRK3 89 9
MARK1 89 3
MNK1 89 8
MKK1 89 4
MKK2 89 2
PKB beta 89 1
JAK2 89 6
MSK1 90 3
TESK1 90 6
WNK1 91 8
MNK2 91 10
AMPK (hum) 91 5
PHK 92 3
SRPK1 92 2
PKC alpha 92 7
PLK1 92 7
MAP4K3 92 1
MARK4 92 7
CLK2 92 9
MAP4K5 92 10
EPH-B3 92 22
PIM1 92 3
PRK2 93 13
ABL 93 0
p38 alpha MAPK 93 3
TIE2 93 4
Lck 93 10
IRR 93 8
IRAK1 93 5
SIK3 94 16
CHK1 94 8
HIPK1 94 11
RIPK2 94 8
STK33 95 4
ERK1 95 16
JNK2 96 23
PAK6 96 12
NUAK1 96 17
Aurora A 96 0
IR 96 15
TGFBR1 96 8
MARK3 96 2
HIPK2 96 6
MINK1 97 9
PINK 97 12
PDK1 97 9
HIPK3 97 4
CK2 97 6
PAK4 98 13
MPSK1 98 11
MAPKAP-K3 98 3
EPH-A4 98 14
EPH-B2 98 6
PKA 99 0
TBK1 99 11
GSK3 beta 99 2
ULK1 99 16
EPH-B4 99 9
EPH-A2 99 11
CHK2 99 3
IKK epsilon 99 8
PDGFRA 100 2
TAO1 100 13
HER4 100 7
PKB alpha 100 28
PAK2 100 2
DYRK1A 101 4
BRK 101 5
YES1 101 9
IKK beta 101 10
S6K1 101 7
p38 beta MAPK 102 1
NEK2a 102 3
CK1 gamma 2 103 6
MEKK1 103 1
PAK5 103 12
MAPKAP-K2 104 11
JNK1 106 2
ASK1 106 1
BRSK1 106 13
ULK2 107 12
PIM2 108 1
BTK 108 6
IRAK4 108 11
MST4 109 8
PIM3 110 6
MST3 110 3
Src 110 3
MST2 111 12
MKK6 111 0
TTBK1 113 2
TTBK2 115 5
PKC zeta 115 11
DDR2 116 13
OSR1 116 22
IGF-1R 117 8