Inhibitor | BX-912  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BX-912   C20H23BrN8O 471.35 702674-56-4 11754511 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ZAP70 100 3
YES1 82 7
WNK1 112 6
VEGFR1
10
 0
ULK2 91 9
ULK1 48 6
TTK 95 10
TTBK2 109 25
TTBK1 94 3
TSSK1 69 11
TrkA 40 4
TLK1 95 10
TIE2 85 2
TGFBR1 87 6
TESK1 102 13
TBK1 45 5
TAO1 81 2
TAK1 49 1
SYK 74 16
STK33 76 4
SRPK1 96 3
Src 89 3
SmMLCK 88 13
SIK3 42 2
SIK2
9
 0
SGK1 87 1
S6K1 80 2
RSK2 62 11
RSK1 82 16
ROCK 2 102 5
RIPK2 68 4
PRK2 68 3
PRAK 112 8
PLK1 106 10
PKD1 81 1
PKC zeta 109 21
PKC gamma 110 3
PKC alpha 82 6
PKB beta 94 10
PKB alpha 87 1
PKA 69 6
PINK 84 2
PIM3 113 3
PIM2 105 4
PIM1 105 1
PHK 101 6
PDK1 43 9
PDGFRA 65 1
PAK6 104 21
PAK5 89 9
PAK4 93 3
PAK2 99 7
p38 gamma MAPK 86 5
p38 delta MAPK 99 33
p38 beta MAPK 92 3
p38 alpha MAPK 96 17
OSR1 100 12
NUAK1
2
 0
NEK6 101 1
NEK2a 101 13
MST4 77 4
MST3 79 5
MST2 56 0
MSK1 100 8
MPSK1 121 1
MNK2 95 4
MNK1 97 17
MLK3 11 1
MLK1 16 0
MKK6 74 12
MKK2 57 5
MKK1 63 3
MINK1 73 7
MELK 72 8
MEKK1 94 6
MARK4 32 5
MARK3 18 1
MARK2 42 5
MARK1 41 4
MAPKAP-K3 106 6
MAPKAP-K2 97 9
MAP4K5 70 2
MAP4K3 75 6
LKB1 79 4
Lck 95 16
JNK3 101 4
JNK2 93 1
JNK1 102 13
JAK2 27 0
IRR 102 12
IRAK4 42 1
IRAK1 100 1
IR 82 25
IKK epsilon 62 1
IKK beta 111 6
IGF-1R 80 3
HIPK3 94 4
HIPK2 92 1
HIPK1 87 14
HER4 94 9
GSK3 beta 87 15
GCK 39 7
FGF-R1 49 6
ERK8 42 5
ERK5 83 2
ERK2 89 3
ERK1 88 3
EPH-B4 104 4
EPH-B3 104 5
EPH-B2 93 11
EPH-B1 109 1
EPH-A4 98 14
EPH-A2 100 5
EIF2AK3 97 1
EF2K 91 24
DYRK3 99 5
DYRK2 101 5
DYRK1A 84 8
DDR2 89 5
DAPK1 100 2
CSK 93 9
CLK2 82 1
CK2 103 11
CK1 gamma 2 99 14
CK1 delta 92 3
CHK2 67 5
CHK1 50 3
CDK9-Cyclin T1 86 6
CDK2-Cyclin A 50 1
CAMKK beta 65 2
CAMK1 93 11
BTK 91 7
BRSK2 50 6
BRSK1 44 1
BRK 89 0
Aurora B
7
 2
Aurora A 62 9
ASK1 96 2
AMPK (hum) 28 1
ABL 87 7
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ZAP70 88 2
YES1 42 8
WNK1 104 4
VEGFR1
2
 0
ULK2 42 4
ULK1 15 1
TTK 76 5
TTBK2 89 6
TTBK1 101 5
TSSK1 45 5
TrkA 17 5
TLK1 91 0
TIE2 58 13
TGFBR1 92 6
TESK1 93 5
TBK1 12 3
TAO1 46 8
TAK1 15 2
SYK 21 4
STK33 33 6
SRPK1 96 13
Src 53 5
SmMLCK 80 5
SIK3 11 1
SIK2
2
 1
SGK1 60 2
S6K1 52 4
RSK2 45 4
RSK1 42 0
ROCK 2 75 2
RIPK2 47 2
PRK2 32 4
PRAK 101 8
PLK1 77 17
PKD1 37 1
PKC zeta 118 6
PKC gamma 86 12
PKC alpha 73 20
PKB beta 91 11
PKB alpha 81 3
PKA 30 1
PINK 88 4
PIM3 104 3
PIM2 105 15
PIM1 105 5
PHK 48 0
PDK1
8
 0
PDGFRA 29 5
PAK6 87 10
PAK5 73 4
PAK4 54 4
PAK2 87 20
p38 gamma MAPK 84 3
p38 delta MAPK 72 4
p38 beta MAPK 85 3
p38 alpha MAPK 91 3
OSR1 89 4
NUAK1
1
 0
NEK6 95 17
NEK2a 82 13
MST4 48 3
MST3 49 3
MST2 31 2
MSK1 74 11
MPSK1 105 2
MNK2 45 2
MNK1 79 2
MLK3 11 5
MLK1
2
 0
MKK6 56 7
MKK2 20 3
MKK1 20 3
MINK1 52 10
MELK 30 3
MEKK1 97 1
MARK4
7
 1
MARK3
4
 1
MARK2 12 2
MARK1
10
 0
MAPKAP-K3 98 4
MAPKAP-K2 103 13
MAP4K5 35 2
MAP4K3 18 2
LKB1 49 6
Lck 43 3
JNK3 76 0
JNK2 59 1
JNK1 74 7
JAK2
10
 2
IRR 73 6
IRAK4
10
 1
IRAK1 48 5
IR 34 7
IKK epsilon 24 1
IKK beta 94 3
IGF-1R 45 4
HIPK3 81 1
HIPK2 90 9
HIPK1 63 7
HER4 69 21
GSK3 beta 81 0
GCK 11 3
FGF-R1
9
 2
ERK8
8
 2
ERK5 63 8
ERK2 63 1
ERK1 67 5
EPH-B4 104 10
EPH-B3 99 6
EPH-B2 79 4
EPH-B1 110 5
EPH-A4 86 3
EPH-A2 87 9
EIF2AK3 94 5
EF2K 101 30
DYRK3 83 3
DYRK2 79 1
DYRK1A 75 8
DDR2 69 4
DAPK1 76 9
CSK 88 9
CLK2 26 0
CK2 80 4
CK1 gamma 2 84 4
CK1 delta 87 3
CHK2 18 2
CHK1 14 0
CDK9-Cyclin T1 60 7
CDK2-Cyclin A 12 4
CAMKK beta 18 0
CAMK1 89 9
BTK 40 7
BRSK2 13 0
BRSK1 12 1
BRK 39 2
Aurora B
2
 1
Aurora A 14 3
ASK1 46 1
AMPK (hum)
5
 1
ABL 35 0