Inhibitor | CAY10576  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
ROCK 2	61	5
MLK1	67	2
MAP4K5	67	3
MST3	70	11
BRK	72	4
ULK1	72	2
EPH-B3	75	24
MAPKAP-K3	75	7
HIPK1	76	8
MST2	77	0
DYRK3	78	2
MST4	79	6
ERK2	79	9
CHK2	79	3
HIPK3	80	1
PINK	80	3
TAO1	82	5
IGF-1R	82	9
MAP4K3	82	7
TIE2	83	2
ERK8	85	2
RSK1	87	6
RSK2	87	9
IKK epsilon	88	6
CDK2-Cyclin A	88	9
MKK6	88	3
EPH-A4	88	9
S6K1	88	3
MARK4	88	8
ULK2	88	2
MAPKAP-K2	88	15
VEGFR1	89	4
PDGFRA	90	1
GCK	90	5
ERK1	90	2
PDK1	90	9
TrkA	90	10
PKC zeta	91	7
FGF-R1	91	3
AMPK (hum)	91	15
TESK1	91	12
TTK	91	8
YES1	91	3
Aurora B	91	5
CK2	91	14
p38 beta MAPK	92	5
PRK2	92	4
EPH-B1	92	1
JNK1	92	7
MEKK1	92	4
MNK1	93	1
PIM3	93	1
NEK2a	93	3
MINK1	93	22
MARK1	94	9
PKB alpha	94	2
CHK1	94	15
PKB beta	95	6
MARK2	95	2
MNK2	95	13
JNK3	96	3
MKK1	96	19
TSSK1	96	4
BTK	96	2
PAK4	96	3
DAPK1	96	3
EF2K	96	4
PKC gamma	96	4
IRAK4	96	4
AMPK	97	1
SIK2	97	9
SYK	97	5
EPH-A2	98	14
MSK1	98	4
p38 delta MAPK	98	1
Aurora A	98	13
IRAK1	98	10
BRSK2	98	9
MKK2	99	2
SGK1	99	7
CLK2	99	3
p38 gamma MAPK	99	7
IRR	99	12
CK1 gamma 2	99	8
JAK2	99	7
RIPK2	100	20
EPH-B4	100	2
CDK9-Cyclin T1	100	8
TAK1	100	4
TLK1	100	8
CK1 delta	100	5
SmMLCK	102	15
WNK1	102	3
SRPK1	102	11
NEK6	102	10
JNK2	103	13
ZAP70	103	15
MELK	103	0
DYRK1A	103	4
PKC alpha	103	3
PHK	103	7
EIF2AK3	103	1
ERK5	103	10
NUAK1	104	11
PIM1	104	11
MPSK1	104	10
MARK3	104	2
DDR2	104	4
IKK beta	104	7
PRAK	105	7
CSK	105	5
HER4	105	7
STK33	105	3
CAMK1	105	1
IR	105	24
PAK2	105	1
PAK6	105	4
GSK3 beta	106	15
MLK3	106	7
OSR1	106	4
HIPK2	106	16
SIK3	106	1
CAMKK beta	107	8
DYRK2	108	13
PKD1	109	8
PIM2	109	7
PKA	109	12
TBK1	110	6
p38 alpha MAPK	111	7
PAK5	111	9
ASK1	112	10
TTBK1	113	14
PLK1	113	8
BRSK1	113	7
ABL	114	1
Lck	116	5
TTBK2	116	17
Src	117	5
TGFBR1	119	22
EPH-B2	123	9
LKB1	123	5

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
MLK1	64	3
MAP4K5	70	15
HIPK1	71	3
ULK1	72	4
ROCK 2	73	3
MST3	73	11
VEGFR1	74	10
MST4	75	6
TIE2	76	10
TAO1	79	10
HIPK3	79	14
PINK	79	9
BRK	79	2
FGF-R1	80	1
MAP4K3	81	7
EPH-B3	81	3
MST2	81	11
MAPKAP-K3	84	2
ERK2	84	3
MINK1	85	1
S6K1	85	1
YES1	87	1
AMPK (hum)	87	4
MAPKAP-K2	88	6
PKA	89	1
IGF-1R	89	9
TTBK2	89	4
ERK8	90	6
PDK1	90	13
CHK2	90	2
CDK2-Cyclin A	90	7
TrkA	90	6
MNK2	91	5
MARK4	91	0
TESK1	92	6
PAK4	92	16
PKC zeta	92	2
ERK1	92	0
MELK	94	4
SIK3	94	8
EF2K	94	3
AMPK	94	1
ULK2	95	6
PIM1	95	11
MKK1	95	3
SGK1	95	9
WNK1	95	1
GCK	95	7
SYK	95	1
MSK1	96	0
RSK1	96	5
DAPK1	96	0
RSK2	96	4
CLK2	96	8
IRAK4	96	4
MARK3	96	15
CAMKK beta	97	1
MNK1	97	6
TLK1	97	2
CK1 delta	97	10
IRAK1	97	14
ERK5	98	2
CSK	98	2
PKC gamma	98	1
RIPK2	98	14
ABL	98	5
MPSK1	98	9
DYRK3	98	13
EPH-B4	99	18
EPH-B1	99	6
BTK	99	18
MARK2	99	2
p38 delta MAPK	99	3
STK33	99	5
JNK1	100	5
Aurora B	100	6
PKC alpha	100	4
TAK1	100	2
MKK6	100	9
TTK	100	5
HER4	100	11
SmMLCK	100	4
Lck	101	2
Aurora A	102	3
CHK1	102	12
CK1 gamma 2	102	3
GSK3 beta	102	4
p38 gamma MAPK	102	9
NEK2a	102	9
DDR2	103	14
SRPK1	103	7
CK2	103	6
PKB beta	103	5
NEK6	103	1
MEKK1	104	4
MLK3	104	2
JNK3	104	1
EPH-A4	104	1
IKK beta	105	17
SIK2	105	10
PIM2	105	7
PKB alpha	105	3
EPH-A2	106	11
EIF2AK3	106	5
PAK6	106	1
PKD1	106	8
DYRK2	106	1
IKK epsilon	107	9
TBK1	107	5
JNK2	107	9
PRK2	107	1
PAK5	107	4
OSR1	107	11
IRR	107	5
PDGFRA	107	0
CAMK1	107	3
CDK9-Cyclin T1	107	18
PLK1	107	4
TGFBR1	108	3
TSSK1	108	9
PIM3	108	7
HIPK2	108	15
NUAK1	109	15
p38 alpha MAPK	109	5
ASK1	109	14
ZAP70	110	2
DYRK1A	110	6
MKK2	111	4
MARK1	112	7
p38 beta MAPK	113	0
BRSK1	113	0
BRSK2	114	11
PHK	114	1
PRAK	115	21
IR	116	21
PAK2	117	2
JAK2	117	1
EPH-B2	119	17
TTBK1	123	7
Src	130	5
LKB1	138	17