Inhibitor | Amgen-NIK-28  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ZAP70 103 11
YES1 107 14
WNK1 103 15
VEGFR1 22 2
ULK2 61 7
ULK1 81 16
TTK 100 1
TTBK2 12 5
TTBK1
8
 1
TSSK1 13 0
TrkA 115 11
TLK1 99 17
TIE2 97 12
TGFBR1 84 9
TESK1 97 4
TBK1 90 5
TAO1
7
 2
TAK1
6
 0
SYK 117 7
STK33 52 0
SRPK1 94 17
Src 82 10
SmMLCK 31 0
SIK3 87 10
SIK2 77 5
SGK1 68 0
S6K1 101 8
RSK2 94 4
RSK1 81 15
ROCK 2 94 1
RIPK2 73 5
PRK2 86 6
PRAK 103 10
PLK1 103 1
PKD1
9
 3
PKC zeta 89 8
PKC gamma 97 2
PKC alpha 102 7
PKB beta 46 4
PKB alpha 54 1
PKA 89 2
PINK 102 4
PIM3 89 3
PIM2 108 7
PIM1 92 5
PHK 80 3
PDK1 101 1
PDGFRA 96 13
PAK6
5
 1
PAK5
3
 1
PAK4
2
 2
PAK2 96 11
p38 gamma MAPK 34 1
p38 delta MAPK 88 6
p38 beta MAPK 100 0
p38 alpha MAPK 113 7
OSR1 88 8
NUAK1 33 3
NEK6 92 13
NEK2a 92 5
MST4 63 3
MST3 72 2
MST2 65 2
MSK1 102 7
MPSK1 89 7
MNK2 92 1
MNK1 108 4
MLK3
2
 0
MLK1
5
 0
MKK6 46 24
MKK2 39 7
MKK1 22 2
MINK1 16 0
MELK 71 2
MEKK1 94 2
MARK4 39 3
MARK3
10
 1
MARK2 42 1
MARK1 38 15
MAPKAP-K3 104 7
MAPKAP-K2 108 10
MAP4K5
5
 1
MAP4K3
2
 1
LKB1 81 6
Lck 94 6
JNK3 89 10
JNK2 86 6
JNK1 86 17
JAK2
10
 2
IRR 103 9
IRAK4 53 10
IRAK1 97 7
IR 72 5
IKK epsilon 28 10
IKK beta 82 4
IGF-1R 118 8
HIPK3 86 26
HIPK2 39 2
HIPK1
3
 0
HER4 108 10
GSK3 beta 30 2
GCK 37 1
FGF-R1 62 2
ERK8 85 0
ERK5 47 3
ERK2 95 5
ERK1 96 6
EPH-B4 98 1
EPH-B3 87 3
EPH-B2 131 16
EPH-B1 101 11
EPH-A4 119 30
EPH-A2 90 2
EIF2AK3 24 4
EF2K 83 9
DYRK3 61 2
DYRK2 76 1
DYRK1A 72 13
DDR2 104 4
DAPK1 82 1
CSK 119 19
CLK2 27 5
CK2 90 3
CK1 gamma 2 92 1
CK1 delta 15 3
CHK2 16 3
CHK1 102 5
CDK9-Cyclin T1 126 1
CDK2-Cyclin A 97 21
CAMKK beta 99 2
CAMK1 69 12
BTK 117 21
BRSK2 84 7
BRSK1 91 5
BRK 87 4
Aurora B 72 3
Aurora A 107 1
ASK1 101 6
AMPK (hum) 71 5
ABL 95 7
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ZAP70 98 3
YES1 118 8
WNK1 107 3
VEGFR1 67 5
ULK2 79 13
ULK1 89 14
TTK 109 0
TTBK2 52 10
TTBK1 47 10
TSSK1 49 2
TrkA 127 6
TLK1 101 4
TIE2 113 11
TGFBR1 83 1
TESK1 105 3
TBK1 104 2
TAO1 30 0
TAK1 29 1
SYK 108 4
STK33 87 8
SRPK1 97 10
Src 107 0
SmMLCK 85 1
SIK3 103 13
SIK2 81 3
SGK1 110 1
S6K1 97 12
RSK2 89 5
RSK1 83 20
ROCK 2 97 1
RIPK2 88 4
PRK2 95 3
PRAK 109 12
PLK1 104 16
PKD1 42 1
PKC zeta 93 5
PKC gamma 105 3
PKC alpha 102 15
PKB beta 90 2
PKB alpha 91 1
PKA 102 1
PINK 110 6
PIM3 109 0
PIM2 115 10
PIM1 108 3
PHK 97 5
PDK1 111 11
PDGFRA 88 4
PAK6 29 1
PAK5 16 1
PAK4 13 3
PAK2 110 2
p38 gamma MAPK 76 0
p38 delta MAPK 86 1
p38 beta MAPK 95 5
p38 alpha MAPK 117 13
OSR1 83 1
NUAK1 77 6
NEK6 103 21
NEK2a 105 3
MST4 107 1
MST3 99 2
MST2 99 1
MSK1 105 13
MPSK1 104 0
MNK2 95 1
MNK1 89 0
MLK3 12 1
MLK1 30 4
MKK6 79 16
MKK2 75 6
MKK1 57 3
MINK1 58 4
MELK 87 13
MEKK1 96 1
MARK4 79 0
MARK3 41 6
MARK2 72 4
MARK1 76 16
MAPKAP-K3 94 21
MAPKAP-K2 108 10
MAP4K5
5
 0
MAP4K3 11 3
LKB1 92 15
Lck 97 5
JNK3 93 14
JNK2 85 12
JNK1 86 4
JAK2 39 4
IRR 116 6
IRAK4 75 6
IRAK1 103 8
IR 96 8
IKK epsilon 87 5
IKK beta 95 18
IGF-1R 106 21
HIPK3 100 1
HIPK2 77 5
HIPK1
7
 0
HER4 104 4
GSK3 beta 85 2
GCK 99 0
FGF-R1 101 14
ERK8 96 0
ERK5 81 2
ERK2 115 5
ERK1 97 8
EPH-B4 89 2
EPH-B3 87 2
EPH-B2 124 7
EPH-B1 105 6
EPH-A4 106 21
EPH-A2 82 7
EIF2AK3 71 7
EF2K 97 4
DYRK3 88 6
DYRK2 91 0
DYRK1A 93 12
DDR2 92 10
DAPK1 97 14
CSK 124 3
CLK2 73 3
CK2 100 9
CK1 gamma 2 103 3
CK1 delta 45 6
CHK2 65 5
CHK1 105 3
CDK9-Cyclin T1 100 3
CDK2-Cyclin A 101 1
CAMKK beta 94 7
CAMK1 98 19
BTK 113 2
BRSK2 101 0
BRSK1 94 1
BRK 98 4
Aurora B 90 5
Aurora A 102 5
ASK1 110 1
AMPK (hum) 109 14
ABL 104 13