Inhibitor | Amgen-NIK-28  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
EPH-B2 131 16
CDK9-Cyclin T1 126 1
EPH-A4 119 30
CSK 119 19
IGF-1R 118 8
BTK 117 21
SYK 117 7
TrkA 115 11
p38 alpha MAPK 113 7
MNK1 108 4
MAPKAP-K2 108 10
HER4 108 10
PIM2 108 7
Aurora A 107 1
YES1 107 14
MAPKAP-K3 104 7
DDR2 104 4
PLK1 103 1
WNK1 103 15
PRAK 103 10
IRR 103 9
ZAP70 103 11
MSK1 102 7
PKC alpha 102 7
CHK1 102 5
PINK 102 4
EPH-B1 101 11
S6K1 101 8
ASK1 101 6
PDK1 101 1
TTK 100 1
p38 beta MAPK 100 0
TLK1 99 17
CAMKK beta 99 2
EPH-B4 98 1
TESK1 97 4
IRAK1 97 7
PKC gamma 97 2
TIE2 97 12
CDK2-Cyclin A 97 21
ERK1 96 6
PAK2 96 11
PDGFRA 96 13
ERK2 95 5
ABL 95 7
SRPK1 94 17
MEKK1 94 2
Lck 94 6
ROCK 2 94 1
RSK2 94 4
CK1 gamma 2 92 1
MNK2 92 1
NEK2a 92 5
NEK6 92 13
PIM1 92 5
BRSK1 91 5
CK2 90 3
TBK1 90 5
EPH-A2 90 2
PIM3 89 3
PKA 89 2
JNK3 89 10
PKC zeta 89 8
MPSK1 89 7
p38 delta MAPK 88 6
OSR1 88 8
EPH-B3 87 3
BRK 87 4
SIK3 87 10
HIPK3 86 26
JNK1 86 17
JNK2 86 6
PRK2 86 6
ERK8 85 0
TGFBR1 84 9
BRSK2 84 7
EF2K 83 9
Src 82 10
DAPK1 82 1
IKK beta 82 4
ULK1 81 16
LKB1 81 6
RSK1 81 15
PHK 80 3
SIK2 77 5
DYRK2 76 1
RIPK2 73 5
Aurora B 72 3
DYRK1A 72 13
IR 72 5
MST3 72 2
AMPK (hum) 71 5
MELK 71 2
CAMK1 69 12
SGK1 68 0
MST2 65 2
MST4 63 3
FGF-R1 62 2
ULK2 61 7
DYRK3 61 2
PKB alpha 54 1
IRAK4 53 10
STK33 52 0
ERK5 47 3
MKK6 46 24
PKB beta 46 4
MARK2 42 1
HIPK2 39 2
MARK4 39 3
MKK2 39 7
MARK1 38 15
GCK 37 1
p38 gamma MAPK 34 1
NUAK1 33 3
SmMLCK 31 0
GSK3 beta 30 2
IKK epsilon 28 10
CLK2 27 5
EIF2AK3 24 4
MKK1 22 2
VEGFR1 22 2
MINK1 16 0
CHK2 16 3
CK1 delta 15 3
TSSK1 13 0
TTBK2 12 5
MARK3
10
 1
JAK2
10
 2
PKD1
9
 3
TTBK1
8
 1
TAO1
7
 2
TAK1
6
 0
MAP4K5
5
 1
MLK1
5
 0
PAK6
5
 1
HIPK1
3
 0
PAK5
3
 1
MAP4K3
2
 1
MLK3
2
 0
PAK4
2
 2
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
TrkA 127 6
EPH-B2 124 7
CSK 124 3
YES1 118 8
p38 alpha MAPK 117 13
IRR 116 6
PIM2 115 10
ERK2 115 5
BTK 113 2
TIE2 113 11
PDK1 111 11
SGK1 110 1
PINK 110 6
PAK2 110 2
ASK1 110 1
TTK 109 0
PIM3 109 0
PRAK 109 12
AMPK (hum) 109 14
PIM1 108 3
SYK 108 4
MAPKAP-K2 108 10
MST4 107 1
WNK1 107 3
Src 107 0
IGF-1R 106 21
EPH-A4 106 21
EPH-B1 105 6
PKC gamma 105 3
TESK1 105 3
MSK1 105 13
NEK2a 105 3
CHK1 105 3
TBK1 104 2
MPSK1 104 0
PLK1 104 16
HER4 104 4
ABL 104 13
SIK3 103 13
CK1 gamma 2 103 3
NEK6 103 21
IRAK1 103 8
PKA 102 1
Aurora A 102 5
PKC alpha 102 15
CDK2-Cyclin A 101 1
TLK1 101 4
FGF-R1 101 14
BRSK2 101 0
CDK9-Cyclin T1 100 3
CK2 100 9
HIPK3 100 1
MST2 99 1
MST3 99 2
GCK 99 0
ZAP70 98 3
BRK 98 4
CAMK1 98 19
ERK1 97 8
S6K1 97 12
SRPK1 97 10
ROCK 2 97 1
EF2K 97 4
Lck 97 5
PHK 97 5
DAPK1 97 14
MEKK1 96 1
ERK8 96 0
IR 96 8
PRK2 95 3
p38 beta MAPK 95 5
MNK2 95 1
IKK beta 95 18
MAPKAP-K3 94 21
CAMKK beta 94 7
BRSK1 94 1
JNK3 93 14
PKC zeta 93 5
DYRK1A 93 12
DDR2 92 10
LKB1 92 15
PKB alpha 91 1
DYRK2 91 0
PKB beta 90 2
Aurora B 90 5
ULK1 89 14
EPH-B4 89 2
MNK1 89 0
RSK2 89 5
RIPK2 88 4
PDGFRA 88 4
DYRK3 88 6
MELK 87 13
IKK epsilon 87 5
EPH-B3 87 2
STK33 87 8
JNK1 86 4
p38 delta MAPK 86 1
GSK3 beta 85 2
JNK2 85 12
SmMLCK 85 1
OSR1 83 1
TGFBR1 83 1
RSK1 83 20
EPH-A2 82 7
SIK2 81 3
ERK5 81 2
MKK6 79 16
ULK2 79 13
MARK4 79 0
NUAK1 77 6
HIPK2 77 5
MARK1 76 16
p38 gamma MAPK 76 0
MKK2 75 6
IRAK4 75 6
CLK2 73 3
MARK2 72 4
EIF2AK3 71 7
VEGFR1 67 5
CHK2 65 5
MINK1 58 4
MKK1 57 3
TTBK2 52 10
TSSK1 49 2
TTBK1 47 10
CK1 delta 45 6
PKD1 42 1
MARK3 41 6
JAK2 39 4
MLK1 30 4
TAO1 30 0
TAK1 29 1
PAK6 29 1
PAK5 16 1
PAK4 13 3
MLK3 12 1
MAP4K3 11 3
HIPK1
7
 0
MAP4K5
5
 0