Inhibitor | MRT199665  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
MRT199665   C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
MARK3
1
 0
MARK4
1
 0
DDR2
1
 0
AMPK
1
 0
NUAK1
2
 0
AMPK (hum)
2
 0
FGF-R1
2
 0
SIK2
3
 0
IGF-1R
3
 1
CLK2
4
 0
SIK3
5
 0
EPH-A2
5
 2
EPH-B1
5
 1
ULK2
5
 3
Src
5
 1
IR
5
 2
JAK2
5
 1
MELK
5
 3
MLK1
6
 1
CSK
6
 3
EPH-A4
7
 2
MLK3
7
 1
Lck
7
 5
TAK1
7
 1
Aurora B
7
 0
MARK2
8
 2
PKD1
8
 3
YES1
8
 3
TrkA
8
 2
VEGFR1
9
 0
MST4 11 1
EPH-B4 11 1
TIE2 12 2
STK33 12 1
MST2 13 2
Aurora A 14 2
BTK 14 2
CAMKK beta 15 3
RSK1 15 0
PHK 15 4
TSSK1 17 2
MST3 18 0
EPH-B2 18 3
ERK8 19 0
ULK1 20 1
MARK1 21 10
PDK1 21 2
CDK2-Cyclin A 21 3
RSK2 22 1
MAP4K3 23 3
IKK epsilon 23 3
CHK1 25 4
PDGFRA 28 9
PAK5 31 0
OSR1 32 3
CDK9-Cyclin T1 34 13
ABL 34 0
PRK2 35 3
ERK2 39 2
TTK 40 2
MAP4K5 40 13
PAK4 40 0
MSK1 41 10
TAO1 43 3
IRAK4 47 3
DYRK1A 49 13
IRR 50 1
PAK2 51 0
SGK1 51 2
PAK6 55 1
JNK2 56 7
CHK2 56 13
SYK 57 7
HIPK2 59 2
ROCK 2 60 3
GSK3 beta 60 5
CAMK1 61 13
GCK 61 14
PKA 62 15
TBK1 64 15
ERK5 64 4
JNK3 67 9
SmMLCK 68 8
CK2 69 3
EF2K 72 16
PKC zeta 72 10
DAPK1 73 4
MINK1 73 0
CK1 delta 76 15
p38 beta MAPK 77 13
p38 delta MAPK 77 2
S6K1 77 15
ERK1 78 1
IKK beta 80 2
PRAK 80 0
HIPK1 81 15
PKB beta 81 1
EPH-B3 82 10
PLK1 82 9
MKK6 83 3
BRK 84 12
CK1 gamma 2 84 15
TESK1 84 8
NEK2a 84 5
JNK1 85 0
PKC alpha 85 5
ASK1 85 11
MAPKAP-K2 85 22
MNK2 86 6
NEK6 86 10
WNK1 87 8
BRSK2 87 15
BRSK1 88 11
LKB1 88 3
RIPK2 88 31
p38 alpha MAPK 89 18
IRAK1 89 7
MAPKAP-K3 89 20
EIF2AK3 90 9
SRPK1 93 0
MPSK1 94 1
PKB alpha 95 5
DYRK2 95 5
DYRK3 95 1
TTBK2 97 5
HIPK3 98 0
HER4 98 2
ZAP70 98 3
PIM1 99 12
MNK1 99 5
TTBK1 100 18
PKC gamma 101 3
p38 gamma MAPK 101 2
TLK1 102 5
PIM2 104 2
MEKK1 107 9
PIM3 109 14
MKK1 117 43
TGFBR1 122 28
MKK2 127 31
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
MARK3
2
 0
MARK4
3
 0
NUAK1
3
 2
MLK1
5
 0
AMPK (hum)
5
 0
AMPK
7
 0
DDR2
8
 0
MLK3
8
 2
IR
8
 3
MELK
8
 1
SIK2
8
 2
Lck
10
 3
MARK2 12 3
IGF-1R 12 0
PKD1 16 1
FGF-R1 19 4
SIK3 19 2
ULK2 20 0
JAK2 22 5
Src 23 0
VEGFR1 25 2
MARK1 25 7
CLK2 25 1
EPH-A4 26 5
EPH-A2 27 8
TrkA 33 1
EPH-B1 34 3
Aurora B 35 1
CAMKK beta 35 1
STK33 35 5
YES1 36 3
PHK 40 11
TAK1 43 12
BTK 44 2
MST2 46 4
MST4 46 4
ERK8 46 3
ULK1 52 6
PDGFRA 53 4
TTK 56 4
MST3 57 7
CDK2-Cyclin A 58 0
TIE2 59 8
RSK1 60 1
RSK2 61 0
PDK1 61 11
EF2K 66 11
Aurora A 66 9
HIPK2 67 7
IKK epsilon 67 15
CHK1 69 2
PRK2 70 4
EPH-B4 71 1
IKK beta 71 10
CSK 75 5
OSR1 75 0
PAK4 76 1
p38 delta MAPK 76 5
TSSK1 76 21
MAP4K5 77 9
PAK5 77 0
ABL 78 7
CDK9-Cyclin T1 78 4
ERK2 79 8
CAMK1 79 6
TAO1 79 9
IRAK1 79 4
PLK1 79 9
CK1 gamma 2 80 2
SGK1 80 10
IRR 80 2
PKB alpha 81 3
MSK1 81 10
PRAK 83 2
EIF2AK3 85 5
TBK1 85 8
PKB beta 87 1
ERK5 87 4
PKC zeta 87 8
GCK 87 8
GSK3 beta 88 7
MNK2 89 2
JNK2 89 9
DAPK1 89 2
CHK2 89 16
MAP4K3 89 14
DYRK3 90 5
ASK1 90 18
DYRK1A 91 8
SmMLCK 91 5
NEK6 91 12
MAPKAP-K2 92 4
MAPKAP-K3 92 9
PKA 92 7
ROCK 2 92 7
NEK2a 92 12
CK2 93 4
MINK1 94 2
MKK2 94 3
HER4 94 4
EPH-B2 94 8
SYK 95 8
MKK6 95 2
HIPK1 95 17
p38 beta MAPK 95 4
MPSK1 95 3
PAK2 96 8
PAK6 96 7
RIPK2 96 17
WNK1 96 3
TESK1 97 10
DYRK2 97 13
ZAP70 98 5
TTBK1 98 2
JNK1 98 7
TLK1 99 1
LKB1 99 6
EPH-B3 100 8
ERK1 100 1
JNK3 100 21
PKC alpha 100 17
p38 alpha MAPK 100 6
p38 gamma MAPK 100 3
IRAK4 101 6
PKC gamma 102 1
SRPK1 103 11
HIPK3 103 6
BRK 103 9
BRSK2 103 3
PIM2 103 0
MNK1 103 10
TTBK2 104 11
S6K1 104 8
PIM1 105 3
BRSK1 107 15
MEKK1 108 3
CK1 delta 109 4
PIM3 116 11
TGFBR1 119 10
MKK1 120 10