Inhibitor | Dimethyl fumarate  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IR	60	5
TSSK1	73	11
Lck	74	2
MARK4	76	21
PAK4	76	5
CDK2-Cyclin A	77	8
SmMLCK	79	24
IKK epsilon	80	4
ROCK 2	81	18
PKB beta	81	4
HIPK3	81	9
PHK	82	23
SIK2	82	14
PRK2	83	31
IKK beta	84	3
TESK1	84	2
FGF-R1	85	7
ERK2	85	10
PAK5	87	9
MAPKAP-K3	87	1
HIPK1	87	22
MLK1	87	18
p38 gamma MAPK	87	9
AMPK (hum)	87	5
CSK	87	5
BTK	88	37
CK1 delta	88	1
TrkA	88	13
IRAK4	88	13
TTBK1	88	3
MST2	88	23
CAMK1	88	9
ERK5	88	0
PKC zeta	89	1
TBK1	89	14
ERK8	89	1
JNK2	90	9
RSK2	90	27
Aurora B	90	11
p38 alpha MAPK	90	11
CHK2	90	2
PAK6	90	0
MEKK1	90	24
RSK1	91	11
SRPK1	91	5
MAP4K5	91	8
BRSK2	91	11
CDK9-Cyclin T1	91	1
MARK2	91	4
DYRK2	91	17
TAO1	91	2
MAP4K3	92	1
CK1 gamma 2	92	1
MAPKAP-K2	92	3
MKK6	92	3
GSK3 beta	92	13
PKD1	92	25
CAMKK beta	92	21
TIE2	92	7
p38 delta MAPK	92	13
PKA	92	14
CLK2	92	9
GCK	92	21
ASK1	93	8
PKB alpha	93	17
LKB1	93	19
TGFBR1	93	4
MELK	93	0
RIPK2	93	17
SGK1	93	8
STK33	93	5
IGF-1R	93	26
PDK1	94	21
PLK1	94	15
MINK1	95	29
EIF2AK3	95	6
ERK1	95	10
MST4	95	17
PIM3	96	17
MKK1	96	20
PRAK	96	0
TTBK2	96	0
OSR1	96	2
ULK1	97	9
EPH-B3	97	13
NUAK1	97	15
ABL	98	3
EPH-A4	98	4
CK2	98	13
HIPK2	98	0
MARK1	98	3
TTK	98	14
SIK3	98	6
JNK1	99	14
DAPK1	99	11
PKC alpha	99	7
EF2K	99	21
S6K1	99	13
PIM1	99	2
NEK2a	100	6
BRSK1	100	30
JAK2	100	11
MLK3	100	14
MNK1	101	6
PAK2	101	1
MNK2	101	1
EPH-B1	101	7
CHK1	101	20
IRAK1	101	3
PDGFRA	101	8
BRK	102	1
IRR	103	9
JNK3	103	4
TLK1	103	8
NEK6	103	19
DDR2	103	1
MARK3	105	24
DYRK3	105	5
TAK1	105	11
MKK2	105	5
DYRK1A	105	7
ULK2	106	2
PKC gamma	106	1
SYK	106	16
AMPK	106	8
MST3	106	23
EPH-A2	106	17
MSK1	107	13
VEGFR1	108	2
WNK1	109	11
HER4	110	18
p38 beta MAPK	111	4
MPSK1	114	9
YES1	114	13
EPH-B4	115	24
ZAP70	116	8
Aurora A	117	3
PIM2	117	12
EPH-B2	118	10
Src	120	22

Screen Conc: 100.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
IR	62	14
Lck	72	3
CDK2-Cyclin A	75	2
MAP4K3	81	7
CSK	82	8
TSSK1	85	7
MAPKAP-K2	86	1
MAP4K5	87	7
PHK	87	30
MKK6	88	10
ERK2	88	27
ASK1	88	7
PAK4	88	19
TESK1	89	4
ROCK 2	89	17
IKK beta	91	5
PRAK	92	5
IGF-1R	92	5
JNK1	92	5
RSK1	92	1
MARK4	92	7
PKB beta	93	6
CHK1	93	9
BRSK1	93	18
TTK	93	11
SIK2	94	17
CK1 delta	94	3
ERK5	94	0
HIPK3	94	6
DYRK2	94	6
JNK2	94	8
PKB alpha	94	7
CK2	95	5
MEKK1	95	13
HIPK1	95	17
AMPK (hum)	95	17
MST2	95	25
p38 gamma MAPK	96	10
SGK1	96	0
PKA	96	19
CAMK1	96	1
TrkA	96	2
IKK epsilon	96	11
GSK3 beta	96	21
MAPKAP-K3	97	4
LKB1	97	15
MLK3	97	2
CDK9-Cyclin T1	98	13
PAK6	98	4
CHK2	98	6
STK33	99	4
ULK1	99	18
ERK1	99	1
TTBK2	99	13
SmMLCK	99	5
BRSK2	99	16
p38 alpha MAPK	99	13
PLK1	100	3
TIE2	100	9
ERK8	100	5
CLK2	100	8
IRAK1	100	1
NEK2a	100	3
TBK1	100	8
DDR2	100	2
CK1 gamma 2	101	9
SRPK1	101	15
TGFBR1	101	24
FGF-R1	101	21
S6K1	101	10
TTBK1	101	3
HIPK2	101	6
CAMKK beta	101	13
PKC alpha	101	2
MKK2	101	13
Aurora B	102	8
p38 delta MAPK	102	18
DAPK1	102	5
MNK1	103	12
PDGFRA	103	0
RSK2	103	21
EPH-B1	103	6
JNK3	103	0
PKC zeta	103	17
MELK	103	14
WNK1	104	19
Src	104	5
AMPK	104	13
PAK2	104	9
RIPK2	104	12
IRAK4	104	8
MST3	104	12
NUAK1	104	3
MSK1	105	7
EPH-A4	105	9
ABL	105	9
JAK2	105	5
EPH-B3	105	5
MST4	106	12
PIM3	106	1
EF2K	106	6
PIM1	107	5
GCK	107	14
MNK2	107	7
EIF2AK3	107	8
PDK1	107	10
OSR1	107	1
MARK2	108	7
PRK2	108	9
MARK3	108	16
IRR	108	10
PKD1	108	11
SIK3	109	27
PIM2	109	9
ULK2	109	5
DYRK1A	109	5
TAO1	109	18
MKK1	109	3
VEGFR1	110	3
NEK6	110	22
p38 beta MAPK	112	20
BRK	112	11
MLK1	112	10
MINK1	113	24
BTK	113	23
PKC gamma	113	14
MARK1	115	1
TAK1	115	1
ZAP70	116	17
YES1	116	19
MPSK1	116	6
TLK1	117	1
DYRK3	117	23
EPH-B2	118	6
SYK	118	17
Aurora A	120	7
EPH-B4	122	10
HER4	123	34
EPH-A2	124	5
PAK5	125	6

Screen Conc:

Kinase	% Activity Remaining Sort descending	Standard Deviation
IR	79	6
TSSK1	80	17
TrkA	83	11
PHK	84	20
PRK2	84	6
Lck	84	2
MAP4K3	85	18
IKK beta	85	8
PAK2	86	7
HIPK3	86	11
CSK	86	3
CDK2-Cyclin A	87	15
RSK1	90	9
MAP4K5	91	20
BRSK1	91	3
CK2	91	2
PLK1	91	6
PIM3	92	8
MAPKAP-K2	93	9
PAK5	93	11
IKK epsilon	93	0
CAMKK beta	93	9
TTK	93	11
PRAK	94	14
HIPK2	94	2
ABL	95	6
PAK4	95	2
TGFBR1	95	11
MARK4	96	12
TTBK2	96	7
ERK8	96	8
CHK1	97	18
IRAK1	97	4
MST2	97	24
ERK5	97	8
ROCK 2	98	19
Aurora B	98	11
VEGFR1	98	2
DDR2	99	23
TIE2	99	13
CAMK1	99	3
PKA	99	15
JNK3	100	17
CHK2	100	2
LKB1	100	1
SGK1	100	11
ERK1	100	14
JNK2	101	13
CK1 gamma 2	101	3
NUAK1	101	16
PIM1	101	2
MST4	101	23
CLK2	101	8
NEK2a	102	5
EIF2AK3	102	20
AMPK (hum)	102	15
STK33	102	2
SmMLCK	102	1
SRPK1	103	11
TAK1	103	0
ULK1	103	17
PKB alpha	103	5
PAK6	103	11
Src	103	14
MKK6	103	26
CDK9-Cyclin T1	103	8
SIK2	103	9
DYRK2	103	2
DAPK1	104	5
EPH-B1	104	15
p38 beta MAPK	104	6
p38 gamma MAPK	104	5
PDGFRA	104	15
MNK1	105	11
ASK1	105	0
PKC alpha	105	18
CK1 delta	105	7
MLK3	105	20
ERK2	105	11
DYRK3	106	8
p38 alpha MAPK	106	14
MAPKAP-K3	106	24
MKK2	106	21
PKB beta	106	6
TBK1	106	28
MELK	107	26
BRSK2	108	15
GSK3 beta	108	18
MARK1	108	16
HER4	108	6
JNK1	109	12
ULK2	109	9
AMPK	109	2
TTBK1	109	27
FGF-R1	109	30
TESK1	109	4
MPSK1	109	11
MNK2	110	14
TLK1	110	1
p38 delta MAPK	110	20
BRK	110	2
SIK3	110	9
PDK1	111	0
EF2K	111	10
RIPK2	111	9
MARK2	111	25
IRR	112	7
MEKK1	112	27
ZAP70	112	2
PKD1	112	14
MST3	112	6
DYRK1A	113	2
MSK1	113	22
Aurora A	114	14
WNK1	114	6
PKC gamma	114	6
EPH-B3	114	12
GCK	114	33
S6K1	115	9
JAK2	116	1
SYK	116	5
OSR1	116	8
PIM2	116	7
RSK2	117	4
IRAK4	117	7
HIPK1	117	31
IGF-1R	117	5
MKK1	118	15
PKC zeta	118	24
YES1	118	10
EPH-A4	119	0
EPH-B2	120	7
TAO1	123	17
NEK6	124	39
MINK1	129	36
EPH-A2	129	12
MARK3	132	9
BTK	135	7
MLK1	135	13
EPH-B4	136	26