Inhibitor | BAY 61-3606  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
NUAK1	1	0
GCK	5	1
IGF-1R	6	1
CLK2	12	2
IR	13	1
TAK1	14	0
ROCK 2	14	1
GSK3 beta	16	2
CDK9-Cyclin T1	21	9
PRK2	21	3
MLK3	22	4
CDK2-Cyclin A	23	1
HIPK2	24	8
DYRK3	24	4
IRR	25	4
MAP4K3	29	4
RIPK2	29	1
PKD1	29	6
IRAK1	31	3
SYK	32	1
MLK1	33	3
DYRK2	36	2
PDGFRA	38	5
ERK8	39	7
CAMKK beta	43	3
MARK3	44	2
PIM3	45	2
BTK	46	1
PKC alpha	46	1
Aurora B	48	1
VEGFR1	50	9
YES1	51	15
MAP4K5	52	0
MKK6	55	2
IKK beta	55	2
MST2	55	3
MNK2	56	1
HIPK1	56	6
DYRK1A	58	1
JAK2	58	7
LKB1	59	0
AMPK (hum)	59	35
MINK1	59	4
IKK epsilon	60	9
JNK3	62	5
Src	63	6
ERK2	65	7
STK33	66	2
ERK5	67	4
FGF-R1	67	15
IRAK4	68	8
ULK1	68	5
PIM1	69	1
TAO1	69	5
MARK2	69	10
ERK1	71	12
TTK	71	1
PAK5	71	3
MELK	71	6
SIK2	72	2
BRK	73	14
MNK1	73	0
HIPK3	73	4
DAPK1	74	1
MARK4	74	12
CK1 delta	75	2
S6K1	75	7
JNK2	75	9
PAK4	75	12
EPH-A2	76	5
Lck	76	1
ASK1	77	0
MST4	78	16
EPH-A4	78	1
BRSK2	78	12
TBK1	78	8
SIK3	79	2
PKB beta	79	15
MST3	79	1
PHK	80	4
PAK6	80	9
MSK1	81	4
PIM2	81	10
RSK1	82	7
SRPK1	82	3
MAPKAP-K3	82	5
EIF2AK3	82	1
NEK2a	82	7
NEK6	82	10
MEKK1	82	2
ZAP70	82	5
MKK2	83	18
CHK2	83	5
TESK1	84	2
HER4	84	4
p38 beta MAPK	84	11
p38 gamma MAPK	84	13
p38 delta MAPK	85	3
PKC zeta	85	7
PLK1	86	12
EPH-B1	86	2
EPH-B2	86	3
BRSK1	86	2
TTBK1	87	10
CSK	88	9
TSSK1	88	14
OSR1	89	11
SGK1	89	6
MARK1	89	5
EF2K	90	3
ABL	91	9
ULK2	91	14
MKK1	92	10
TrkA	92	47
DDR2	92	9
CK1 gamma 2	93	11
TLK1	93	4
CK2	93	9
EPH-B4	93	2
PDK1	94	17
SmMLCK	94	16
JNK1	94	3
TGFBR1	94	2
WNK1	96	7
TTBK2	98	2
PKA	99	12
EPH-B3	99	8
CAMK1	100	11
AMPK	101	2
PAK2	102	6
PRAK	103	18
MPSK1	103	13
PKC gamma	103	12
PKB alpha	106	12
p38 alpha MAPK	107	10
CHK1	108	12
RSK2	113	12
TIE2	113	2
Aurora A	114	17
MAPKAP-K2	146	51

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
GCK	4	1
IGF-1R	10	4
CLK2	14	1
GSK3 beta	15	5
IR	16	1
TAK1	16	1
ROCK 2	18	0
MLK3	20	1
DYRK3	24	2
CDK2-Cyclin A	25	3
HIPK2	25	1
NUAK1	26	1
CDK9-Cyclin T1	26	7
PKD1	27	1
IRR	29	2
IRAK1	31	0
RIPK2	32	0
PRK2	32	3
MAP4K3	34	4
SYK	36	2
MLK1	36	2
CAMKK beta	37	8
PDGFRA	40	1
Aurora B	40	3
DYRK2	40	0
MARK3	49	7
MST2	50	8
LKB1	50	5
IKK epsilon	51	1
DYRK1A	51	0
Src	54	12
ERK8	55	23
PKC alpha	56	1
IKK beta	56	4
MAP4K5	56	5
MARK2	56	5
PIM1	59	9
BTK	59	1
MKK6	62	3
HIPK1	62	12
MELK	63	13
YES1	63	15
MARK4	64	3
TSSK1	65	17
ERK5	67	1
CHK2	68	3
ERK2	68	7
JAK2	69	7
ERK1	69	7
MNK2	69	11
FGF-R1	69	11
PIM3	70	41
VEGFR1	71	15
p38 beta MAPK	71	2
EF2K	71	1
HIPK3	71	2
CK1 delta	72	4
JNK2	72	11
JNK3	73	11
ULK1	73	1
PAK5	74	2
TTK	74	10
MSK1	74	5
Lck	74	8
PAK4	74	7
MST3	75	10
STK33	75	5
SIK2	75	2
S6K1	75	4
TESK1	75	7
TAO1	75	2
PKC zeta	76	5
p38 gamma MAPK	76	8
BRSK2	77	10
DAPK1	77	9
IRAK4	78	9
EPH-B1	78	2
MINK1	78	7
ZAP70	79	7
PLK1	79	9
NEK2a	79	7
TrkA	80	30
MKK2	80	6
TLK1	80	12
SRPK1	81	1
MKK1	82	6
PAK6	82	3
ASK1	82	7
MST4	83	5
PIM2	83	9
MNK1	83	4
PKA	84	2
PHK	84	12
TBK1	85	13
JNK1	85	3
CSK	85	8
p38 delta MAPK	87	0
EPH-B2	87	1
AMPK	87	3
EPH-A4	88	10
MEKK1	88	10
BRSK1	89	11
BRK	89	1
EPH-B3	89	1
EPH-B4	89	8
AMPK (hum)	89	12
MARK1	89	2
PAK2	89	1
SIK3	90	4
CHK1	91	18
PKB alpha	92	6
CK1 gamma 2	92	4
DDR2	93	1
OSR1	93	13
TTBK1	93	19
PDK1	94	3
WNK1	95	9
MAPKAP-K3	95	21
EIF2AK3	95	2
EPH-A2	96	15
ULK2	96	4
CK2	96	9
MPSK1	98	24
TGFBR1	98	7
TTBK2	98	10
NEK6	99	17
PKC gamma	99	4
MAPKAP-K2	99	4
SGK1	100	1
ABL	100	6
PRAK	101	7
CAMK1	101	3
RSK1	102	21
p38 alpha MAPK	103	10
HER4	103	2
TIE2	105	0
PKB beta	106	19
Aurora A	110	12
SmMLCK	111	10
RSK2	117	3