Inhibitor | NG-25  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
NG-25   C29H30F3N5O2 537.58 1315355-93-1 53340664 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371 Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
Lck
1
 0
p38 alpha MAPK
3
 2
ABL
4
 0
TAK1
7
 2
Src
10
 1
YES1
10
 1
MINK1 11 4
OSR1 11 0
GCK 12 4
CSK 15 4
VEGFR1 15 5
p38 beta MAPK 17 4
CAMK1 17 3
EPH-A2 20 4
JNK2 22 2
EPH-B2 23 5
FGF-R1 24 9
EPH-A4 29 1
EPH-B3 29 4
p38 delta MAPK 34 0
p38 gamma MAPK 38 1
BRK 43 4
MSK1 46 1
SYK 47 4
MLK3 50 2
HIPK2 60 7
JNK1 62 2
S6K1 64 7
EIF2AK3 65 2
TAO1 67 19
HIPK3 70 7
HIPK1 71 4
ROCK 2 71 4
CAMKK beta 71 3
IRAK1 72 6
SGK1 73 12
MARK2 74 6
HER4 77 19
MST4 78 10
TrkA 78 2
RIPK2 79 3
DAPK1 81 10
IR 82 4
MAPKAP-K3 82 6
RSK1 84 15
PKC alpha 84 1
NEK6 85 5
IGF-1R 85 11
BTK 85 4
PKD1 86 1
DYRK3 86 13
ERK8 89 15
SmMLCK 89 2
ZAP70 90 1
MLK1 90 9
PAK6 90 5
IRR 91 2
NUAK1 91 4
TIE2 91 1
MPSK1 91 4
AMPK 92 5
JAK2 92 8
PLK1 92 3
JNK3 92 3
TLK1 92 11
EPH-B4 93 10
PKA 93 3
PRK2 93 7
CK2 94 1
RSK2 94 1
PIM2 95 16
BRSK2 95 16
PKC zeta 96 1
BRSK1 96 4
STK33 97 7
IKK epsilon 97 21
MARK1 97 3
PRAK 97 5
SRPK1 97 0
DYRK1A 98 5
TTK 98 1
MELK 99 5
MARK3 99 17
PAK4 99 11
PDK1 100 2
PAK2 100 3
PKB alpha 100 19
TBK1 100 21
IKK beta 101 4
DYRK2 101 13
EF2K 102 3
IRAK4 102 0
ERK2 102 4
PKC gamma 102 4
ERK1 103 5
CHK2 103 21
PAK5 104 10
MNK1 104 1
GSK3 beta 104 8
CLK2 104 9
MARK4 104 4
CHK1 105 5
ASK1 105 1
EPH-B1 106 4
LKB1 107 6
NEK2a 107 3
PIM3 108 18
Aurora B 108 7
MKK1 108 8
MEKK1 111 4
PHK 112 1
MNK2 112 13
CDK2-Cyclin A 112 6
PKB beta 114 0
CK1 delta 115 7
MKK2 116 13
PIM1 117 7
Aurora A 121 14
MAPKAP-K2 122 1
MST2 124 10
MKK6 158 0
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL
1
 0
OSR1
2
 0
p38 alpha MAPK
3
 2
EPH-B2
3
 0
VEGFR1
3
 2
Src
3
 1
TAK1
4
 1
CAMK1
4
 2
JNK2
5
 2
MINK1
5
 0
IGF-1R
6
 1
Lck
6
 8
BRK
7
 2
p38 delta MAPK
7
 2
FGF-R1
8
 1
EPH-A4
8
 0
CSK
8
 4
EPH-B3
8
 1
MLK3
9
 0
p38 beta MAPK
9
 0
GCK
9
 5
YES1 11 0
p38 gamma MAPK 11 9
SYK 12 1
HIPK2 13 3
S6K1 13 3
EPH-A2 14 8
RIPK2 14 4
JNK1 14 2
IR 18 1
HIPK3 20 3
EIF2AK3 21 5
CAMKK beta 21 2
MSK1 21 2
ROCK 2 25 2
TAO1 27 7
HIPK1 29 7
JNK3 32 4
MST4 32 1
IRAK1 33 10
BTK 34 9
HER4 37 0
RSK1 38 6
PKD1 39 1
MLK1 40 4
JAK2 42 3
TrkA 43 2
EPH-B4 43 5
IKK beta 45 2
ERK8 45 7
IRR 46 4
PKB beta 49 8
SGK1 52 10
ZAP70 60 5
TIE2 60 3
MELK 64 4
TTK 66 1
EPH-B1 67 17
CHK2 68 4
PKB alpha 69 8
PAK2 69 8
SRPK1 73 8
NEK6 73 7
RSK2 76 1
ASK1 76 5
CLK2 76 7
PKA 76 0
SmMLCK 77 4
PAK4 78 5
PRK2 79 6
IKK epsilon 80 26
STK33 80 5
DYRK3 82 13
MNK1 83 11
MNK2 83 2
DAPK1 84 0
PDK1 85 1
NUAK1 85 4
AMPK 85 2
MARK2 85 4
DYRK1A 85 23
PIM1 87 10
PAK5 88 5
BRSK2 89 0
IRAK4 89 17
MARK4 89 1
PKC alpha 90 6
MST2 91 14
TLK1 92 5
PRAK 92 13
NEK2a 93 3
MKK1 93 8
PKC zeta 93 4
PAK6 94 19
CK1 delta 94 13
PLK1 95 0
DYRK2 95 16
TBK1 96 4
MAPKAP-K3 97 5
MKK2 97 16
MPSK1 99 14
CK2 99 2
PIM3 99 4
EF2K 100 17
CDK2-Cyclin A 100 1
ERK1 100 11
GSK3 beta 101 15
PHK 102 10
PIM2 102 11
Aurora A 102 1
MARK1 103 9
MARK3 105 10
PKC gamma 106 7
ERK2 106 0
MEKK1 108 12
BRSK1 109 7
CHK1 110 2
MAPKAP-K2 113 14
Aurora B 118 16
LKB1 129 36
MKK6 133 2
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
TAK1 11 2
Lck 13 2
GCK 24 3
p38 alpha MAPK 41 5
ABL 51 1
YES1 53 6
OSR1 54 0
Src 66 3
CAMK1 69 2
VEGFR1 70 7
EPH-A2 74 5
p38 beta MAPK 75 4
MINK1 76 15
FGF-R1 79 1
MSK1 81 9
IRAK1 81 14
CSK 82 3
IR 86 9
NUAK1 86 3
EPH-B2 88 21
p38 gamma MAPK 89 1
DAPK1 89 6
CK2 90 9
MAPKAP-K3 90 13
TTK 91 10
JNK2 91 9
ROCK 2 92 7
ZAP70 92 10
JAK2 93 12
MARK2 93 4
PKC alpha 94 2
JNK1 94 13
RSK2 95 19
MLK3 95 6
HIPK1 95 1
MST4 95 7
TIE2 95 1
EPH-A4 96 7
EPH-B3 97 7
DYRK3 97 9
EPH-B4 97 2
CAMKK beta 98 0
MNK1 98 8
PDK1 98 2
IRAK4 99 13
p38 delta MAPK 99 1
TAO1 99 16
EIF2AK3 99 3
PKC zeta 99 3
ERK1 99 18
PKA 100 1
BRSK2 100 1
BRK 101 10
BRSK1 101 10
SGK1 101 16
PKD1 101 2
ERK2 101 2
DYRK2 102 20
PHK 102 4
SRPK1 102 10
PRK2 102 4
GSK3 beta 102 1
PLK1 103 5
RIPK2 103 4
BTK 103 15
MPSK1 103 1
SYK 103 2
PAK6 104 12
NEK6 104 14
PKB alpha 105 14
HER4 105 3
PRAK 105 22
PKB beta 105 3
HIPK2 105 8
ERK8 106 8
PIM2 106 5
MLK1 106 23
MKK1 106 19
AMPK 106 2
IKK epsilon 106 12
STK33 106 15
IGF-1R 107 12
S6K1 107 4
DYRK1A 107 5
RSK1 107 1
PIM3 107 9
TLK1 107 10
PKC gamma 108 9
PAK5 108 9
SmMLCK 109 5
MNK2 109 6
PAK4 109 2
CDK2-Cyclin A 110 4
HIPK3 110 11
EF2K 110 14
MAPKAP-K2 110 12
MST2 111 23
EPH-B1 111 8
ASK1 111 10
TrkA 111 5
MARK3 112 15
NEK2a 112 8
IRR 112 5
CK1 delta 112 9
TBK1 113 20
MARK1 114 12
CHK1 114 8
IKK beta 114 1
CLK2 115 6
MELK 115 17
JNK3 116 12
MARK4 116 2
PAK2 116 8
Aurora B 116 13
LKB1 117 1
CHK2 117 16
MKK6 118 5
PIM1 120 0
Aurora A 120 9
MEKK1 127 7
MKK2 131 0