Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
BX-795 | C23H26IN7O2S | 591.47 | 702675-74-9 | 10077147 | PDK1 | Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874 |
Kinase Sort descending | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 51 | 0 |
Aurora B | 17 | 1 |
Aurora C | 26 | 3 |
BRSK2 | 91 | 3 |
BTK | 107 | 4 |
CAMK1 | 86 | 10 |
CAMKK alpha | 85 | 13 |
CAMKK beta | 82 | 5 |
CDK2-Cyclin A | 56 | 6 |
CHK1 | 83 | 5 |
CHK2 | 90 | 0 |
CK1 delta | 78 | 4 |
CK2 | 93 | 10 |
CSK | 113 | 11 |
DYRK1A | 94 | 7 |
DYRK2 | 104 | 9 |
DYRK3 | 85 | 9 |
EF2K | 97 | 5 |
EPH-A2 | 109 | 7 |
EPH-B3 | 110 | 6 |
ERK1 | 81 | 8 |
ERK2 | 88 | 3 |
ERK8 | 40 | 3 |
FGF-R1 | 84 | 11 |
GSK3 beta | 82 | 14 |
HIPK2 | 95 | 11 |
HIPK3 | 94 | 1 |
IGF-1R | 108 | 8 |
IKK beta | 108 | 2 |
IKK epsilon | 40 | 6 |
IR | 85 | 13 |
IRR | 89 | 0 |
JNK1 | 103 | 6 |
JNK2 | 100 | 12 |
JNK3 | 93 | 3 |
Lck | 97 | 3 |
MAPKAP-K2 | 107 | 8 |
MAPKAP-K3 | 102 | 6 |
MARK3 | 12 | 0 |
MELK | 95 | 3 |
MKK1 | 49 | 3 |
MNK1 | 80 | 7 |
MNK2 | 46 | 3 |
MSK1 | 88 | 0 |
MST2 | 95 | 2 |
MST4 | 126 | 11 |
NEK2a | 91 | 6 |
NEK6 | 95 | 3 |
NEK7 | 110 | 7 |
p38 alpha MAPK | 85 | 2 |
p38 beta MAPK | 93 | 13 |
p38 delta MAPK | 90 | 5 |
p38 gamma MAPK | 94 | 2 |
PAK4 | 90 | 14 |
PAK5 | 97 | 2 |
PAK6 | 91 | 2 |
PDK1 | 29 | 2 |
PHK | 94 | 12 |
PIM1 | 102 | 7 |
PIM2 | 108 | 2 |
PIM3 | 95 | 7 |
PKA | 101 | 1 |
PKB alpha | 90 | 14 |
PKB beta | 112 | 6 |
PKC alpha | 105 | 1 |
PKC zeta | 95 | 11 |
PKD1 | 83 | 3 |
PLK1 | 94 | 6 |
PRAK | 96 | 5 |
PRK2 | 79 | 4 |
ROCK 2 | 90 | 6 |
RSK1 | 100 | 6 |
RSK2 | 100 | 9 |
S6K1 | 100 | 3 |
SGK1 | 86 | 6 |
SmMLCK | 110 | 5 |
Src | 90 | 4 |
SRPK1 | 98 | 11 |
SYK | 89 | 9 |
TBK1 | 25 | 2 |
VEGFR1 | 75 | 10 |
YES1 | 90 | 6 |
Kinase Sort descending | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 23 | 2 |
Aurora A | 20 | 2 |
Aurora B |
5
|
0 |
BRSK1 | 77 | 21 |
BRSK2 | 78 | 5 |
BTK | 100 | 15 |
CAMK1 | 107 | 10 |
CAMKK beta | 30 | 1 |
CDK2-Cyclin A | 19 | 6 |
CHK1 | 57 | 5 |
CHK2 | 74 | 5 |
CK1 delta | 106 | 21 |
CK2 | 99 | 9 |
CLK2 | 65 | 8 |
CSK | 91 | 6 |
DAPK1 | 87 | 4 |
DYRK1A | 91 | 2 |
DYRK2 | 81 | 5 |
DYRK3 | 82 | 5 |
EF2K | 113 | 3 |
EPH-A2 | 79 | 12 |
EPH-A4 | 100 | 9 |
EPH-B2 | 112 | 5 |
EPH-B3 | 100 | 2 |
EPH-B4 | 94 | 5 |
ERK1 | 95 | 13 |
ERK2 | 91 | 3 |
ERK8 | 72 | 58 |
FGF-R1 | 46 | 3 |
GCK | 21 | 5 |
GSK3 beta | 71 | 4 |
HER4 | 98 | 1 |
HIPK1 | 105 | 3 |
HIPK2 | 87 | 8 |
HIPK3 | 103 | 4 |
IGF-1R | 111 | 15 |
IKK beta | 106 | 0 |
IKK epsilon |
9
|
0 |
IR | 103 | 17 |
IRAK4 | 76 | 7 |
IRR | 57 | 3 |
JAK2 |
7
|
0 |
JNK1 | 100 | 3 |
JNK2 | 98 | 5 |
JNK3 | 93 | 3 |
Lck | 104 | 4 |
LKB1 | 120 | 4 |
MAPKAP-K2 | 108 | 2 |
MAPKAP-K3 | 99 | 2 |
MARK1 | 13 | 2 |
MARK2 |
10
|
1 |
MARK3 |
6
|
1 |
MARK4 | 15 | 3 |
MEKK1 | 78 | 3 |
MELK | 57 | 3 |
MINK1 | 105 | 6 |
MKK1 | 64 | 16 |
MLK1 | 17 | 2 |
MLK3 | 11 | 0 |
MNK1 | 60 | 0 |
MNK2 | 18 | 7 |
MSK1 | 84 | 5 |
MST2 | 106 | 6 |
MST4 | 145 | 12 |
NEK2a | 100 | 11 |
NEK6 | 106 | 12 |
NUAK1 |
7
|
4 |
p38 alpha MAPK | 104 | 10 |
p38 beta MAPK | 71 | 1 |
p38 delta MAPK | 102 | 11 |
p38 gamma MAPK | 97 | 7 |
PAK2 | 106 | 3 |
PAK4 | 97 | 8 |
PAK5 | 100 | 8 |
PAK6 | 114 | 4 |
PDK1 |
9
|
2 |
PHK | 71 | 2 |
PIM1 | 107 | 4 |
PIM2 | 98 | 9 |
PIM3 | 99 | 1 |
PKA | 96 | 0 |
PKB alpha | 117 | 11 |
PKB beta | 104 | 1 |
PKC alpha | 87 | 8 |
PKC zeta | 96 | 0 |
PKD1 | 78 | 0 |
PLK1 | 95 | 2 |
PRAK | 106 | 3 |
PRK2 | 58 | 3 |
RIPK2 | 105 | 3 |
ROCK 2 | 58 | 7 |
RSK1 | 83 | 5 |
RSK2 | 102 | 17 |
S6K1 | 89 | 1 |
SGK1 | 95 | 4 |
SmMLCK | 93 | 4 |
Src | 98 | 6 |
SRPK1 | 108 | 4 |
SYK | 91 | 12 |
TAK1 |
8
|
1 |
TBK1 |
9
|
4 |
TrkA | 52 | 2 |
TTK | 89 | 5 |
VEGFR1 | 37 | 1 |
YES1 | 117 | 0 |
Kinase Sort descending | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK |
1
|
0 |
Aurora B |
1
|
0 |
Aurora C |
2
|
2 |
BRSK2 |
0
|
0 |
CAMK1 | 12 | 2 |
CAMKK beta |
10
|
1 |
CDK2-Cyclin A |
0
|
0 |
CHK1 |
2
|
0 |
CHK2 |
2
|
0 |
CK1 delta | 83 | 3 |
CK2 | 38 | 5 |
CSK | 69 | 3 |
DYRK1A | 35 | 16 |
DYRK2 |
7
|
0 |
DYRK3 |
4
|
7 |
EF2K | 74 | 1 |
EPH-A2 | 66 | 6 |
ERK1 |
5
|
0 |
ERK2 |
6
|
0 |
ERK8 |
2
|
1 |
FGF-R1 |
2
|
0 |
GSK3 beta |
3
|
0 |
HIPK2 | 14 | 0 |
HIPK3 | 33 | 2 |
IKK beta | 41 | 1 |
IKK epsilon |
0
|
0 |
IRR |
10
|
0 |
JNK1 | 16 | 1 |
JNK2 | 17 | 5 |
JNK3 | 38 | 0 |
Lck | 14 | 0 |
MAPKAP-K2 | 70 | 8 |
MAPKAP-K3 | 80 | 1 |
MARK3 |
2
|
2 |
MELK |
4
|
1 |
MKK1 |
2
|
0 |
MNK1 |
1
|
0 |
MNK2 |
6
|
8 |
MSK1 | 25 | 4 |
MST2 | 15 | 2 |
MST4 | 13 | 1 |
NEK2a |
7
|
0 |
NEK6 | 63 | 8 |
NEK7 | 84 | 9 |
p38 alpha MAPK | 87 | 10 |
p38 beta MAPK | 60 | 3 |
p38 delta MAPK | 27 | 1 |
p38 gamma MAPK | 17 | 3 |
PAK4 |
6
|
4 |
PAK5 | 15 | 4 |
PAK6 | 16 | 3 |
PDK1 |
1
|
0 |
PHK |
2
|
1 |
PIM1 | 53 | 0 |
PIM2 | 75 | 9 |
PIM3 | 18 | 6 |
PKA |
10
|
0 |
PKB alpha | 46 | 7 |
PKB beta | 55 | 11 |
PKC alpha |
10
|
0 |
PKC zeta | 66 | 7 |
PKD1 |
2
|
0 |
PLK1 | 55 | 0 |
PRAK | 43 | 0 |
PRK2 |
1
|
7 |
ROCK 2 |
2
|
0 |
RSK1 |
4
|
1 |
RSK2 | 11 | 0 |
S6K1 |
6
|
0 |
SGK1 |
8
|
0 |
SmMLCK | 84 | 10 |
Src |
10
|
0 |
SRPK1 | 79 | 15 |
SYK |
6
|
4 |
TBK1 |
2
|
0 |
YES1 | 11 | 1 |
Kinase Sort descending | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK |
3
|
0 |
Aurora A |
2
|
0 |
Aurora B |
3
|
1 |
BRSK1 | 34 | 0 |
BRSK2 | 31 | 4 |
BTK | 61 | 10 |
CAMK1 | 79 | 2 |
CAMKK beta | 13 | 0 |
CDK2-Cyclin A |
5
|
4 |
CHK1 | 19 | 1 |
CHK2 | 20 | 1 |
CK1 delta | 93 | 3 |
CK2 | 87 | 1 |
CLK2 | 13 | 1 |
CSK | 65 | 6 |
DAPK1 | 38 | 5 |
DYRK1A | 58 | 1 |
DYRK2 | 28 | 1 |
DYRK3 | 24 | 2 |
EF2K | 99 | 2 |
EPH-A2 | 70 | 2 |
EPH-A4 | 82 | 1 |
EPH-B2 | 100 | 2 |
EPH-B3 | 115 | 37 |
EPH-B4 | 94 | 16 |
ERK1 | 48 | 9 |
ERK2 | 46 | 1 |
ERK8 | 16 | 3 |
FGF-R1 | 12 | 0 |
GCK |
10
|
2 |
GSK3 beta | 17 | 3 |
HER4 | 82 | 2 |
HIPK1 | 82 | 6 |
HIPK2 | 59 | 0 |
HIPK3 | 76 | 7 |
IGF-1R | 85 | 13 |
IKK beta | 82 | 4 |
IKK epsilon |
5
|
0 |
IR | 77 | 1 |
IRAK4 | 22 | 1 |
IRR | 28 | 1 |
JAK2 |
2
|
1 |
JNK1 | 69 | 2 |
JNK2 | 57 | 4 |
JNK3 | 68 | 6 |
Lck | 66 | 0 |
LKB1 | 63 | 8 |
MAPKAP-K2 | 88 | 8 |
MAPKAP-K3 | 93 | 5 |
MARK1 |
8
|
1 |
MARK2 |
5
|
1 |
MARK3 |
3
|
1 |
MARK4 |
9
|
0 |
MEKK1 | 32 | 2 |
MELK | 11 | 1 |
MINK1 | 70 | 2 |
MKK1 | 21 | 1 |
MLK1 |
5
|
1 |
MLK3 |
2
|
0 |
MNK1 | 18 | 0 |
MNK2 | 15 | 8 |
MSK1 | 60 | 6 |
MST2 | 64 | 8 |
MST4 | 111 | 1 |
NEK2a | 64 | 4 |
NEK6 | 80 | 10 |
NUAK1 |
7
|
0 |
p38 alpha MAPK | 108 | 4 |
p38 beta MAPK | 89 | 1 |
p38 delta MAPK | 58 | 5 |
p38 gamma MAPK | 61 | 2 |
PAK2 | 94 | 2 |
PAK4 | 40 | 1 |
PAK5 | 66 | 3 |
PAK6 | 87 | 10 |
PDK1 |
3
|
0 |
PHK | 27 | 2 |
PIM1 | 92 | 4 |
PIM2 | 92 | 8 |
PIM3 | 74 | 2 |
PKA | 64 | 4 |
PKB alpha | 93 | 2 |
PKB beta | 95 | 1 |
PKC alpha | 50 | 12 |
PKC zeta | 90 | 1 |
PKD1 | 22 | 1 |
PLK1 | 93 | 7 |
PRAK | 91 | 14 |
PRK2 | 18 | 1 |
RIPK2 | 77 | 1 |
ROCK 2 |
10
|
2 |
RSK1 | 28 | 1 |
RSK2 | 42 | 5 |
S6K1 | 37 | 2 |
SGK1 | 42 | 2 |
SmMLCK | 92 | 1 |
Src | 64 | 4 |
SRPK1 | 101 | 0 |
SYK | 35 | 3 |
TAK1 |
1
|
0 |
TBK1 |
6
|
2 |
TrkA | 28 | 2 |
TTK | 53 | 14 |
VEGFR1 |
8
|
1 |
YES1 | 66 | 4 |