Inhibitor | BX-795  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BX-795   C23H26IN7O2S 591.47 702675-74-9 10077147 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
CDK2-Cyclin A
0
 0
IKK epsilon
0
 0
BRSK2
0
 0
PDK1
1
 0
Aurora B
1
 0
MNK1
1
 0
AMPK
1
 0
PRK2
1
 7
PKD1
2
 0
FGF-R1
2
 0
Aurora C
2
 2
MKK1
2
 0
PHK
2
 1
ERK8
2
 1
CHK1
2
 0
MARK3
2
 2
ROCK 2
2
 0
CHK2
2
 0
TBK1
2
 0
GSK3 beta
3
 0
DYRK3
4
 7
RSK1
4
 1
MELK
4
 1
ERK1
5
 0
PAK4
6
 4
S6K1
6
 0
MNK2
6
 8
ERK2
6
 0
SYK
6
 4
NEK2a
7
 0
DYRK2
7
 0
SGK1
8
 0
PKC alpha
10
 0
CAMKK beta
10
 1
Src
10
 0
PKA
10
 0
IRR
10
 0
YES1 11 1
RSK2 11 0
CAMK1 12 2
MST4 13 1
HIPK2 14 0
Lck 14 0
PAK5 15 4
MST2 15 2
PAK6 16 3
JNK1 16 1
p38 gamma MAPK 17 3
JNK2 17 5
PIM3 18 6
MSK1 25 4
p38 delta MAPK 27 1
HIPK3 33 2
DYRK1A 35 16
JNK3 38 0
CK2 38 5
IKK beta 41 1
PRAK 43 0
PKB alpha 46 7
PIM1 53 0
PLK1 55 0
PKB beta 55 11
p38 beta MAPK 60 3
NEK6 63 8
EPH-A2 66 6
PKC zeta 66 7
CSK 69 3
MAPKAP-K2 70 8
EF2K 74 1
PIM2 75 9
SRPK1 79 15
MAPKAP-K3 80 1
CK1 delta 83 3
SmMLCK 84 10
NEK7 84 9
p38 alpha MAPK 87 10
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
TAK1
1
 0
MLK3
2
 0
Aurora A
2
 0
JAK2
2
 1
MARK3
3
 1
Aurora B
3
 1
PDK1
3
 0
AMPK
3
 0
MARK2
5
 1
CDK2-Cyclin A
5
 4
MLK1
5
 1
IKK epsilon
5
 0
TBK1
6
 2
NUAK1
7
 0
VEGFR1
8
 1
MARK1
8
 1
MARK4
9
 0
GCK
10
 2
ROCK 2
10
 2
MELK 11 1
FGF-R1 12 0
CAMKK beta 13 0
CLK2 13 1
MNK2 15 8
ERK8 16 3
GSK3 beta 17 3
PRK2 18 1
MNK1 18 0
CHK1 19 1
CHK2 20 1
MKK1 21 1
PKD1 22 1
IRAK4 22 1
DYRK3 24 2
PHK 27 2
DYRK2 28 1
IRR 28 1
RSK1 28 1
TrkA 28 2
BRSK2 31 4
MEKK1 32 2
BRSK1 34 0
SYK 35 3
S6K1 37 2
DAPK1 38 5
PAK4 40 1
RSK2 42 5
SGK1 42 2
ERK2 46 1
ERK1 48 9
PKC alpha 50 12
TTK 53 14
JNK2 57 4
DYRK1A 58 1
p38 delta MAPK 58 5
HIPK2 59 0
MSK1 60 6
BTK 61 10
p38 gamma MAPK 61 2
LKB1 63 8
PKA 64 4
NEK2a 64 4
MST2 64 8
Src 64 4
CSK 65 6
PAK5 66 3
Lck 66 0
YES1 66 4
JNK3 68 6
JNK1 69 2
MINK1 70 2
EPH-A2 70 2
PIM3 74 2
HIPK3 76 7
RIPK2 77 1
IR 77 1
CAMK1 79 2
NEK6 80 10
HER4 82 2
IKK beta 82 4
HIPK1 82 6
EPH-A4 82 1
IGF-1R 85 13
CK2 87 1
PAK6 87 10
MAPKAP-K2 88 8
p38 beta MAPK 89 1
PKC zeta 90 1
PRAK 91 14
PIM1 92 4
PIM2 92 8
SmMLCK 92 1
PLK1 93 7
PKB alpha 93 2
CK1 delta 93 3
MAPKAP-K3 93 5
PAK2 94 2
EPH-B4 94 16
PKB beta 95 1
EF2K 99 2
EPH-B2 100 2
SRPK1 101 0
p38 alpha MAPK 108 4
MST4 111 1
EPH-B3 115 37
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
Aurora B
5
 0
MARK3
6
 1
JAK2
7
 0
NUAK1
7
 4
TAK1
8
 1
PDK1
9
 2
IKK epsilon
9
 0
TBK1
9
 4
MARK2
10
 1
MLK3 11 0
MARK1 13 2
MARK4 15 3
MLK1 17 2
MNK2 18 7
CDK2-Cyclin A 19 6
Aurora A 20 2
GCK 21 5
AMPK 23 2
CAMKK beta 30 1
VEGFR1 37 1
FGF-R1 46 3
TrkA 52 2
MELK 57 3
IRR 57 3
CHK1 57 5
ROCK 2 58 7
PRK2 58 3
MNK1 60 0
MKK1 64 16
CLK2 65 8
GSK3 beta 71 4
p38 beta MAPK 71 1
PHK 71 2
ERK8 72 58
CHK2 74 5
IRAK4 76 7
BRSK1 77 21
PKD1 78 0
MEKK1 78 3
BRSK2 78 5
EPH-A2 79 12
DYRK2 81 5
DYRK3 82 5
RSK1 83 5
MSK1 84 5
PKC alpha 87 8
HIPK2 87 8
DAPK1 87 4
S6K1 89 1
TTK 89 5
SYK 91 12
ERK2 91 3
DYRK1A 91 2
CSK 91 6
JNK3 93 3
SmMLCK 93 4
EPH-B4 94 5
ERK1 95 13
PLK1 95 2
SGK1 95 4
PKC zeta 96 0
PKA 96 0
p38 gamma MAPK 97 7
PAK4 97 8
PIM2 98 9
HER4 98 1
Src 98 6
JNK2 98 5
PIM3 99 1
CK2 99 9
MAPKAP-K3 99 2
EPH-A4 100 9
EPH-B3 100 2
JNK1 100 3
NEK2a 100 11
PAK5 100 8
BTK 100 15
p38 delta MAPK 102 11
RSK2 102 17
HIPK3 103 4
IR 103 17
p38 alpha MAPK 104 10
PKB beta 104 1
Lck 104 4
MINK1 105 6
HIPK1 105 3
RIPK2 105 3
PRAK 106 3
IKK beta 106 0
MST2 106 6
CK1 delta 106 21
PAK2 106 3
NEK6 106 12
PIM1 107 4
CAMK1 107 10
SRPK1 108 4
MAPKAP-K2 108 2
IGF-1R 111 15
EPH-B2 112 5
EF2K 113 3
PAK6 114 4
PKB alpha 117 11
YES1 117 0
LKB1 120 4
MST4 145 12
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
MARK3 12 0
Aurora B 17 1
TBK1 25 2
Aurora C 26 3
PDK1 29 2
ERK8 40 3
IKK epsilon 40 6
MNK2 46 3
MKK1 49 3
AMPK 51 0
CDK2-Cyclin A 56 6
VEGFR1 75 10
CK1 delta 78 4
PRK2 79 4
MNK1 80 7
ERK1 81 8
CAMKK beta 82 5
GSK3 beta 82 14
PKD1 83 3
CHK1 83 5
FGF-R1 84 11
IR 85 13
CAMKK alpha 85 13
DYRK3 85 9
p38 alpha MAPK 85 2
CAMK1 86 10
SGK1 86 6
ERK2 88 3
MSK1 88 0
IRR 89 0
SYK 89 9
PAK4 90 14
YES1 90 6
Src 90 4
ROCK 2 90 6
CHK2 90 0
PKB alpha 90 14
p38 delta MAPK 90 5
PAK6 91 2
NEK2a 91 6
BRSK2 91 3
CK2 93 10
p38 beta MAPK 93 13
JNK3 93 3
PLK1 94 6
DYRK1A 94 7
PHK 94 12
p38 gamma MAPK 94 2
HIPK3 94 1
PKC zeta 95 11
PIM3 95 7
MST2 95 2
NEK6 95 3
MELK 95 3
HIPK2 95 11
PRAK 96 5
PAK5 97 2
Lck 97 3
EF2K 97 5
SRPK1 98 11
RSK1 100 6
S6K1 100 3
JNK2 100 12
RSK2 100 9
PKA 101 1
PIM1 102 7
MAPKAP-K3 102 6
JNK1 103 6
DYRK2 104 9
PKC alpha 105 1
MAPKAP-K2 107 8
BTK 107 4
PIM2 108 2
IGF-1R 108 8
IKK beta 108 2
EPH-A2 109 7
SmMLCK 110 5
EPH-B3 110 6
NEK7 110 7
PKB beta 112 6
CSK 113 11
MST4 126 11