Inhibitor | OSU-03012  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CAMK1	21	0
S6K1	21	7
PAK6	28	1
SGK1	30	1
TAK1	36	11
SmMLCK	42	30
DAPK1	43	8
CHK1	44	4
MSK1	46	3
MINK1	47	7
PKB alpha	53	0
PKB beta	54	2
PKC zeta	61	3
NUAK1	61	4
NEK6	63	0
RSK1	63	9
ERK1	63	1
PRK2	63	3
BRSK2	64	3
HIPK3	64	3
CLK2	64	7
PIM3	64	2
EPH-B1	67	9
HIPK2	69	14
p38 gamma MAPK	70	1
p38 delta MAPK	70	2
MST3	70	6
PAK4	70	1
MST4	72	3
PHK	72	0
MAP4K3	73	19
MAP4K5	73	0
MKK6	74	4
EF2K	75	18
ERK8	75	4
MELK	75	5
IRR	75	12
PAK2	75	7
CHK2	76	14
PRAK	76	11
PDK1	77	7
CK2	79	11
IRAK4	79	8
MARK1	79	3
SIK2	79	3
p38 alpha MAPK	80	4
IRAK1	80	11
MLK1	80	2
YES1	80	2
SRPK1	80	3
MST2	81	15
RIPK2	81	13
DYRK1A	82	18
EPH-B3	82	9
ZAP70	83	19
TBK1	83	7
CDK9-Cyclin T1	83	3
MNK1	83	0
TSSK1	83	15
ASK1	83	0
SYK	85	2
CSK	85	13
JNK3	86	10
TTK	86	1
MLK3	87	9
ROCK 2	87	8
IKK beta	88	3
ERK2	88	13
EPH-B4	88	21
Aurora B	88	3
BRSK1	89	6
MARK2	89	7
VEGFR1	89	9
ERK5	89	1
PKC alpha	90	9
HIPK1	90	19
TrkA	90	3
CK1 gamma 2	90	7
EPH-B2	91	4
BRK	91	3
EPH-A4	91	2
STK33	92	9
GCK	92	9
TAO1	92	7
NEK2a	92	8
CK1 delta	93	12
PKD1	93	10
PKA	93	10
IR	94	2
AMPK (hum)	94	11
PIM1	94	2
EPH-A2	94	2
MAPKAP-K2	95	2
p38 beta MAPK	95	7
EIF2AK3	95	20
CDK2-Cyclin A	95	2
JNK2	96	8
BTK	96	11
PKC gamma	97	0
MAPKAP-K3	97	1
MPSK1	97	20
ULK1	97	14
TGFBR1	98	0
RSK2	98	60
PIM2	98	4
PDGFRA	98	8
LKB1	99	3
ULK2	101	22
IKK epsilon	101	2
DDR2	101	8
SIK3	101	1
MARK3	101	2
MARK4	102	9
MEKK1	103	3
TESK1	103	6
ABL	103	6
JNK1	103	3
HER4	104	7
TLK1	104	14
IGF-1R	105	4
AMPK	105	10
TIE2	105	24
DYRK3	105	21
WNK1	105	1
OSR1	106	26
PAK5	107	9
MKK1	107	7
Aurora A	107	13
MNK2	109	17
PLK1	111	11
MKK2	113	14
CAMKK beta	115	4
JAK2	116	27
GSK3 beta	119	4
DYRK2	121	4
FGF-R1	128	20
TTBK1	129	28
Src	135	15
TTBK2	154	2
Lck	247	13

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
SGK1	71	2
CHK1	72	10
EPH-B1	72	3
EPH-B3	72	2
TAK1	74	7
BRSK2	76	14
MINK1	78	6
ERK8	79	4
PDK1	79	6
VEGFR1	79	16
PHK	79	15
RSK2	80	23
EPH-A4	80	15
ERK1	80	11
MST4	80	8
MAP4K5	80	1
MKK6	82	4
PDGFRA	82	1
EPH-B2	82	19
CDK9-Cyclin T1	82	0
BRSK1	83	5
ULK2	83	21
IRAK4	84	7
MST3	84	8
Lck	84	3
TESK1	84	7
ZAP70	84	3
MAP4K3	84	14
PAK4	84	1
NUAK1	85	4
YES1	85	13
JNK3	85	2
PRK2	85	1
PKD1	86	9
S6K1	86	13
MNK1	86	2
ASK1	86	2
ULK1	86	3
PAK5	87	7
RSK1	87	9
IKK beta	87	3
PKB beta	87	8
MARK1	87	2
SYK	87	21
PAK6	88	3
TTBK1	88	6
AMPK (hum)	88	1
HIPK2	88	5
ROCK 2	88	7
MARK4	88	5
TLK1	89	3
PRAK	89	6
DYRK2	89	1
TrkA	90	5
TTK	90	9
BRK	91	2
MAPKAP-K2	91	1
IRR	91	3
PKB alpha	91	16
ERK5	91	2
STK33	91	2
SIK3	91	4
MNK2	91	11
EPH-A2	92	9
MELK	92	2
DDR2	92	0
PIM1	92	8
p38 beta MAPK	92	10
MEKK1	93	6
RIPK2	93	9
PIM2	93	4
CLK2	93	6
Aurora B	93	3
CK1 gamma 2	93	5
PKC alpha	94	1
PKC zeta	94	3
MLK3	94	11
HIPK3	94	3
MARK2	94	7
p38 gamma MAPK	94	7
SRPK1	94	2
PKC gamma	95	3
CDK2-Cyclin A	95	1
OSR1	95	4
SIK2	95	6
PLK1	95	6
Aurora A	95	19
ABL	95	11
DAPK1	95	4
CK1 delta	96	14
TTBK2	96	8
MARK3	96	3
NEK2a	96	9
p38 delta MAPK	96	11
CSK	97	12
IRAK1	98	20
IR	98	0
CHK2	98	22
TGFBR1	98	7
BTK	98	0
AMPK	99	1
MLK1	99	10
PIM3	99	11
IGF-1R	100	23
PKA	100	12
MPSK1	100	24
p38 alpha MAPK	100	0
ERK2	101	16
JAK2	101	0
EIF2AK3	102	3
JNK2	102	8
TSSK1	102	20
EF2K	103	24
MAPKAP-K3	103	6
LKB1	103	3
Src	103	18
TAO1	103	5
TIE2	103	13
HIPK1	104	4
DYRK1A	105	27
HER4	106	11
MST2	106	18
JNK1	107	11
GCK	107	11
PAK2	107	6
MKK1	108	1
DYRK3	108	6
CAMK1	109	7
SmMLCK	109	6
GSK3 beta	110	2
MSK1	110	10
CK2	111	2
FGF-R1	111	17
IKK epsilon	114	33
NEK6	115	7
EPH-B4	116	6
WNK1	119	21
CAMKK beta	120	26
TBK1	120	31
MKK2	123	10