Inhibitor | PF4708671  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PF4708671   C19H21F3N6 390.41 1255517-76-0 S6K1 Pearce (2010) Biochem.J. 431 245

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
RSK1
0
 2
MSK1
6
 0
S6K1
6
 2
RSK2 25 7
PKA 34 10
VEGFR1 37 2
MST4 46 3
AMPK 46 1
Aurora B 49 9
PKB alpha 52 5
ROCK 2 58 10
PKB beta 60 2
PKC alpha 62 0
FGF-R1 63 1
SGK1 65 6
PKD1 67 3
PKC zeta 70 16
ERK8 71 9
CK1 delta 71 2
CHK2 72 6
YES1 76 7
MST2 77 3
IRR 77 16
PIM1 78 6
EF2K 78 4
MAPKAP-K2 78 13
CAMK1 78 12
MNK1 79 2
MNK2 79 11
CAMKK beta 80 1
NEK6 80 11
MARK3 82 0
IGF-1R 82 9
ERK1 83 28
PIM3 83 2
BRSK2 83 2
CK2 83 12
DYRK3 83 11
CHK1 83 5
PRK2 84 3
DYRK1A 85 3
ERK2 86 6
p38 alpha MAPK 86 5
PAK6 86 4
MELK 87 1
PAK5 87 0
PRAK 87 6
SmMLCK 87 16
CDK2-Cyclin A 88 8
PLK1 88 4
HIPK2 88 2
PAK4 88 7
Lck 88 6
EPH-A2 89 15
SYK 91 4
p38 delta MAPK 91 3
NEK2a 91 3
GSK3 beta 92 2
BTK 92 8
Src 92 4
JNK1 95 0
PDK1 95 2
IKK epsilon 96 5
IR 96 8
MKK1 96 1
p38 beta MAPK 97 11
TBK1 97 2
JNK2 98 5
CSK 98 6
PIM2 100 12
SRPK1 101 16
EPH-B3 101 5
DYRK2 101 2
IKK beta 102 3
p38 gamma MAPK 103 4
PHK 104 7
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
S6K1 16 2
RSK1 33 4
MSK1 34 2
RSK2 67 8
PKB alpha 69 5
CHK2 73 17
PKB beta 73 2
EF2K 73 2
SGK1 74 7
NEK6 75 2
PKC zeta 75 19
MST4 77 5
SmMLCK 79 3
p38 alpha MAPK 79 12
p38 delta MAPK 82 0
ERK8 83 16
CHK1 83 16
PKA 83 1
PKD1 83 5
MARK3 83 4
VEGFR1 83 3
PAK6 83 9
YES1 84 1
BRSK2 84 6
ERK1 85 9
MST2 85 5
ERK2 85 1
PDK1 86 16
EPH-A2 86 5
PRK2 86 7
HIPK2 86 16
PLK1 87 1
Aurora B 87 3
BTK 87 7
PIM3 88 8
AMPK 88 3
PAK4 88 3
PAK5 88 11
p38 beta MAPK 89 10
PIM1 90 4
PIM2 90 7
ROCK 2 91 12
MNK1 91 3
Lck 92 10
DYRK3 92 6
FGF-R1 92 2
CK2 92 2
CSK 93 6
JNK2 93 2
MNK2 93 10
CK1 delta 93 3
CAMK1 94 22
NEK2a 94 3
DYRK1A 94 6
IGF-1R 95 19
IR 95 5
PHK 96 10
IRR 96 14
GSK3 beta 96 8
PRAK 97 10
CAMKK beta 98 0
IKK epsilon 99 1
Src 99 31
SYK 100 12
CDK2-Cyclin A 101 10
MELK 101 11
p38 gamma MAPK 102 0
DYRK2 104 3
MKK1 104 2
TBK1 105 12
MAPKAP-K2 105 3
SRPK1 106 15
PKC alpha 106 9
JNK1 107 6
IKK beta 119 11
EPH-B3 139 6
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
S6K1 39 8
RSK1 46 0
IGF-1R 72 6
PKB beta 74 7
PKC zeta 78 8
MSK1 80 6
BTK 83 4
PKA 84 0
ERK8 85 1
p38 alpha MAPK 86 3
RSK2 86 3
PKB alpha 87 2
GSK3 beta 87 5
MST4 87 4
p38 beta MAPK 88 7
BRSK2 88 4
MAPKAP-K2 88 22
NEK6 88 4
IRR 88 8
PIM1 88 2
Aurora B 89 5
p38 delta MAPK 89 10
EF2K 90 1
PDK1 90 6
CHK1 90 17
PIM2 90 6
Lck 91 7
FGF-R1 91 1
MNK2 92 2
JNK2 92 3
PAK4 93 7
ERK1 93 16
ERK2 93 8
PIM3 93 2
PKD1 94 5
MARK3 94 8
MELK 94 5
CSK 94 10
MST2 95 3
SmMLCK 95 9
NEK2a 95 3
EPH-A2 95 12
PRK2 95 1
CK1 delta 96 7
CK2 96 10
VEGFR1 97 10
DYRK2 97 17
ROCK 2 98 2
PLK1 98 6
YES1 98 1
PAK6 99 3
CAMKK beta 99 12
DYRK1A 99 4
AMPK 100 0
PAK5 100 23
PHK 100 7
MNK1 101 1
CHK2 101 3
CDK2-Cyclin A 102 21
IKK epsilon 103 6
Src 103 10
IKK beta 104 2
CAMK1 106 9
DYRK3 106 2
SGK1 106 3
p38 gamma MAPK 107 10
SRPK1 108 11
TBK1 108 7
HIPK2 108 8
IR 108 5
JNK1 111 34
PRAK 114 10
MKK1 117 8
PKC alpha 119 10
SYK 121 14
EPH-B3 132 2