Inhibitor | BX-517 Analog (compound 7b)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 11588244 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
CHK2
-5
 0
PHK
1
 0
MKK1
1
 0
MST2
2
 1
DYRK2
2
 0
FGF-R1
2
 0
ERK8
2
 0
PKD1
3
 0
MELK
3
 0
PDK1
3
 0
VEGFR1
3
 1
DYRK3
4
 1
CHK1
4
 0
MARK3
5
 1
PRK2
5
 3
AMPK
6
 4
HIPK2
7
 0
Src
7
 0
TBK1
7
 6
GSK3 beta
7
 3
YES1
8
 0
PIM1
9
 0
PIM3
9
 2
RSK1
10
 4
BRSK2
10
 3
Lck
10
 0
DYRK1A 11 6
SmMLCK 11 1
IKK epsilon 12 1
CDK2-Cyclin A 14 2
IRR 16 5
MST4 18 0
BTK 29 5
PAK4 31 0
RSK2 32 14
SGK1 32 0
S6K1 32 0
IGF-1R 33 7
PIM2 34 0
ROCK 2 37 4
SYK 40 1
ERK2 41 9
CAMKK beta 41 12
PLK1 42 4
PAK5 43 0
JNK2 43 0
MNK2 46 5
MAPKAP-K2 49 6
PRAK 50 6
MNK1 54 0
EPH-A2 54 5
CK1 delta 59 10
ERK1 60 52
p38 delta MAPK 62 1
CK2 65 5
PKC zeta 66 1
PKA 66 0
PKB alpha 69 0
CAMK1 69 5
CSK 69 6
MSK1 73 2
NEK2a 75 2
IKK beta 75 27
SRPK1 75 1
NEK6 76 10
PAK6 77 3
PKB beta 77 7
p38 alpha MAPK 80 4
p38 beta MAPK 80 5
PKC alpha 83 5
EF2K 86 3
p38 gamma MAPK 86 4
EPH-B3 90 11
JNK1 99 1
IR 101 11
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
CHK2
-1
 0
AMPK
5
 0
ERK8
5
 0
VEGFR1
7
 0
MKK1
8
 1
MST2
8
 0
GSK3 beta 11 1
BRSK2 13 3
PHK 13 0
MARK3 16 3
MELK 16 0
FGF-R1 17 3
DYRK2 19 3
DYRK3 19 3
PDK1 20 1
RSK1 24 4
PRK2 25 11
TBK1 27 17
PKD1 30 2
PIM3 30 0
YES1 32 4
HIPK2 33 1
IRR 35 0
RSK2 38 4
Src 41 2
DYRK1A 42 9
PIM1 43 2
Lck 44 4
IGF-1R 49 49
IKK epsilon 51 14
SmMLCK 54 7
MST4 55 32
CDK2-Cyclin A 63 0
PAK4 64 5
CAMKK beta 67 7
ERK1 71 7
IKK beta 75 1
MNK2 75 12
PAK5 75 10
S6K1 76 0
PIM2 76 6
SGK1 77 5
PKA 78 0
MNK1 80 0
ERK2 81 10
p38 alpha MAPK 81 8
CHK1 85 2
PKC zeta 85 4
p38 delta MAPK 85 9
PKB alpha 85 4
PLK1 86 5
BTK 86 11
MAPKAP-K2 86 3
PAK6 86 1
PKB beta 88 3
CK1 delta 90 0
SRPK1 90 4
NEK6 92 6
p38 gamma MAPK 93 6
EPH-A2 93 0
CK2 93 17
PRAK 95 6
SYK 95 23
CSK 98 0
MSK1 98 1
NEK2a 100 10
EF2K 102 14
ROCK 2 103 25
p38 beta MAPK 103 0
PKC alpha 106 3
EPH-B3 107 1
IR 112 14
CAMK1 112 12
JNK1 124 1
JNK2 214 172
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
DYRK2
0
 0
PHK
0
 0
MST2
0
 0
PDK1
0
 2
MELK
0
 0
SmMLCK
1
 1
Src
1
 0
DYRK3
1
 0
FGF-R1
1
 0
CHK1
1
 0
ERK8
1
 0
CHK2
1
 4
IGF-1R
1
 0
HIPK2
1
 0
VEGFR1
1
 0
MKK1
2
 1
PIM1
2
 2
PKD1
3
 2
Lck
3
 0
GSK3 beta
3
 2
YES1
3
 1
MARK3
3
 1
ERK1
4
 0
AMPK
4
 1
IRR
5
 2
RSK1
5
 0
SGK1
6
 2
CDK2-Cyclin A
6
 0
PRK2
6
 0
ROCK 2
7
 1
SYK
7
 0
PIM3
7
 2
PIM2
8
 0
PRAK
8
 1
PAK5
8
 0
BTK
9
 6
MAPKAP-K2
10
 6
IKK epsilon 11 6
TBK1 11 9
S6K1 12 1
MNK2 16 2
ERK2 16 3
JNK2 17 0
PLK1 18 6
BRSK2 18 3
CAMK1 19 0
EPH-A2 20 1
CK1 delta 20 5
CK2 21 1
MST4 21 6
PKC zeta 21 4
p38 delta MAPK 22 1
RSK2 22 3
IKK beta 26 4
IR 26 6
DYRK1A 27 33
PKC alpha 27 7
NEK2a 28 1
PAK4 29 31
MSK1 30 0
MNK1 30 14
PKA 32 5
CAMKK beta 35 3
PKB beta 36 4
SRPK1 36 3
PAK6 38 4
NEK6 38 2
CSK 42 6
p38 alpha MAPK 45 6
JNK1 48 4
p38 beta MAPK 49 9
EPH-B3 53 8
PKB alpha 62 7
p38 gamma MAPK 75 27
EF2K 116 7