Inhibitor | Hypothemycin  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Hypothemycin   C19H22O8 378.37 76958-67-3 6474405 cyclin D1 H. Sonoda (1999) Life Sci. 65 381 A. Zhao (1999) J. Antibiot. 52 1086

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ZAP70 101 7
YES1 85 18
WNK1 107 1
VEGFR1
5
 2
ULK2 96 2
ULK1 88 1
TTK 95 13
TTBK1 82 15
TSSK1 110 8
TrkA 90 19
TLK1 101 7
TIE2 101 11
TESK1 107 6
TBK1 112 6
TAO1 101 2
TAK1 48 5
SYK 108 2
STK33 105 1
SRPK1 95 11
Src 91 5
SmMLCK 102 4
SIK3 93 7
SIK2 107 2
SGK1 91 15
S6K1 92 9
RSK2 125 19
RSK1 92 10
ROCK 2 94 15
RIPK2 102 8
PRK2 101 23
PRAK 72 17
PLK1 107 7
PKD1 41 1
PKC zeta 78 12
PKC gamma 109 4
PKC alpha 88 3
PKB beta 103 7
PKB alpha 124 2
PKA 99 3
PIM3 98 6
PIM2 114 2
PIM1 87 10
PHK 98 2
PDK1 88 22
PAK6 95 4
PAK5 115 2
PAK4 100 5
PAK2 94 6
p38 gamma MAPK 105 18
p38 delta MAPK 100 3
p38 beta MAPK 93 1
p38 alpha MAPK 105 6
OSR1 99 4
NUAK1 99 3
NEK6 90 12
NEK2a 127 7
MST4 106 9
MST3 104 3
MST2 89 9
MSK1 104 10
MPSK1 86 30
MNK2 62 16
MNK1 87 5
MLK3 102 0
MLK1 117 4
MKK6 21 12
MKK2 21 1
MKK1 21 5
MINK1 111 8
MELK 100 2
MEKK1 101 13
MARK4 99 3
MARK3 102 3
MARK2 100 1
MARK1 99 2
MAPKAP-K3 99 2
MAPKAP-K2 101 4
LKB1 120 19
Lck 93 1
JNK3 101 18
JNK2 106 6
JNK1 98 8
JAK2 101 6
IRR 108 3
IRAK4 99 5
IRAK1 97 7
IR 116 1
IKK epsilon 105 4
IKK beta 100 3
IGF-1R 100 14
HIPK3 100 0
HIPK2 86 5
HIPK1 99 19
HER4 104 14
GSK3 beta 106 5
GCK 105 3
FGF-R1 154 18
ERK8 27 0
ERK2 87 17
ERK1 102 9
EPH-B4 116 14
EPH-B3 130 12
EPH-B2 118 2
EPH-B1 110 3
EPH-A4 122 2
EPH-A2 98 5
EIF2AK3 92 5
EF2K 103 4
DYRK3 109 3
DYRK2 105 6
DYRK1A 105 4
DDR2 113 10
DAPK1 108 10
CSK 105 9
CLK2 100 3
CK2 121 5
CK1 gamma 2 100 2
CK1 delta 101 3
CHK2 91 12
CHK1 93 14
CDK9-Cyclin T1 117 17
CDK2-Cyclin A 81 9
CAMKK beta 99 9
CAMK1 96 13
BTK 115 11
BRSK2 93 12
BRSK1 90 9
BRK 100 24
Aurora B 92 4
Aurora A 103 6
ASK1 103 3
AMPK 105 14
ABL 97 4
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ZAP70 103 10
YES1 81 21
WNK1 106 3
VEGFR1
3
 0
ULK2 118 35
ULK1 92 15
TTK 101 5
TTBK1 112 35
TSSK1 99 7
TrkA 67 9
TLK1 120 31
TIE2 122 11
TESK1 92 12
TBK1 93 5
TAO1 100 5
TAK1
2
 1
SYK 85 2
STK33 113 5
SRPK1 100 4
Src 86 3
SmMLCK 96 2
SIK3 94 7
SIK2 88 10
SGK1 104 17
S6K1 106 5
RSK2 129 19
RSK1 85 4
ROCK 2 99 13
RIPK2 85 6
PRK2 89 27
PRAK 32 3
PLK1 114 2
PKD1 11 1
PKC zeta 105 5
PKC gamma 89 0
PKC alpha 92 13
PKB beta 99 21
PKB alpha 107 3
PKA 100 18
PIM3 99 6
PIM2 117 29
PIM1 92 5
PHK 107 7
PDK1 93 9
PAK6 95 13
PAK5 103 20
PAK4 104 31
PAK2 95 13
p38 gamma MAPK 114 28
p38 delta MAPK 108 0
p38 beta MAPK 98 3
p38 alpha MAPK 105 13
OSR1 129 30
NUAK1 105 16
NEK6 98 7
NEK2a 105 4
MST4 86 1
MST3 114 13
MST2 102 3
MSK1 104 8
MPSK1 102 4
MNK2 44 6
MNK1 55 3
MLK3 90 9
MLK1 101 7
MKK6 20 15
MKK2
9
 0
MKK1
1
 1
MINK1 102 16
MELK 104 7
MEKK1 102 13
MARK4 94 23
MARK3 95 13
MARK2 100 4
MARK1 101 9
MAPKAP-K3 99 9
MAPKAP-K2 109 22
LKB1 104 2
Lck 69 8
JNK3 107 5
JNK2 99 3
JNK1 80 3
JAK2 109 25
IRR 113 11
IRAK4 57 2
IRAK1 109 43
IR 97 4
IKK epsilon 92 9
IKK beta 112 10
IGF-1R 119 44
HIPK3 102 4
HIPK2 72 12
HIPK1 95 12
HER4 105 3
GSK3 beta 113 48
GCK 97 7
FGF-R1 132 24
ERK8 11 0
ERK2 36 3
ERK1 57 3
EPH-B4 116 35
EPH-B3 92 6
EPH-B2 115 0
EPH-B1 84 9
EPH-A4 107 3
EPH-A2 56 3
EIF2AK3 121 48
EF2K 133 26
DYRK3 124 6
DYRK2 102 24
DYRK1A 101 11
DDR2 133 55
DAPK1 96 14
CSK 95 24
CLK2 114 24
CK2 133 7
CK1 gamma 2 109 6
CK1 delta 92 22
CHK2 106 20
CHK1 94 12
CDK9-Cyclin T1 111 3
CDK2-Cyclin A 76 2
CAMKK beta 94 29
CAMK1 112 6
BTK 109 2
BRSK2 96 3
BRSK1 82 9
BRK 48 2
Aurora B 107 1
Aurora A 108 5
ASK1 109 4
AMPK 94 3
ABL 105 5
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
ZAP70 99 20
YES1 87 0
WNK1 94 2
VEGFR1 65 15
ULK2 94 3
ULK1 91 2
TTK 101 4
TTBK1 89 4
TSSK1 112 9
TrkA 97 0
TLK1 95 5
TIE2 122 14
TESK1 120 36
TBK1 110 7
TAO1 106 3
TAK1 101 5
SYK 112 26
STK33 113 9
SRPK1 111 19
Src 96 15
SmMLCK 108 7
SIK3 102 4
SIK2 106 9
SGK1 93 2
S6K1 87 11
RSK2 129 16
RSK1 97 22
ROCK 2 91 5
RIPK2 104 10
PRK2 93 8
PRAK 74 11
PLK1 102 0
PKD1 89 13
PKC zeta 97 11
PKC gamma 103 17
PKC alpha 88 15
PKB beta 105 2
PKB alpha 109 2
PKA 91 10
PIM3 92 7
PIM2 93 3
PIM1 90 6
PHK 100 7
PDK1 89 5
PAK6 92 1
PAK5 102 0
PAK4 81 9
PAK2 99 1
p38 gamma MAPK 100 1
p38 delta MAPK 101 6
p38 beta MAPK 88 6
p38 alpha MAPK 108 18
OSR1 104 3
NUAK1 93 5
NEK6 97 19
NEK2a 103 11
MST4 96 9
MST3 106 10
MST2 97 6
MSK1 108 11
MPSK1 94 5
MNK2 91 2
MNK1 100 6
MLK3 91 20
MLK1 112 12
MKK6 59 0
MKK2 74 0
MKK1 101 3
MINK1 106 7
MELK 92 2
MEKK1 112 1
MARK4 103 1
MARK3 98 5
MARK2 90 7
MARK1 101 5
MAPKAP-K3 105 19
MAPKAP-K2 93 7
LKB1 119 10
Lck 79 6
JNK3 89 11
JNK2 105 14
JNK1 104 14
JAK2 84 2
IRR 104 2
IRAK4 112 3
IRAK1 97 4
IR 112 18
IKK epsilon 108 9
IKK beta 103 3
IGF-1R 103 14
HIPK3 104 1
HIPK2 96 12
HIPK1 111 9
HER4 132 24
GSK3 beta 91 5
GCK 114 7
FGF-R1 118 7
ERK8 80 14
ERK2 96 9
ERK1 111 5
EPH-B4 109 1
EPH-B3 118 19
EPH-B2 124 15
EPH-B1 97 5
EPH-A4 109 10
EPH-A2 97 3
EIF2AK3 105 6
EF2K 91 6
DYRK3 113 6
DYRK2 109 4
DYRK1A 98 1
DDR2 91 11
DAPK1 82 18
CSK 97 25
CLK2 94 2
CK2 123 1
CK1 gamma 2 100 10
CK1 delta 116 5
CHK2 91 3
CHK1 93 15
CDK9-Cyclin T1 97 5
CDK2-Cyclin A 91 6
CAMKK beta 102 10
CAMK1 96 0
BTK 105 9
BRSK2 114 11
BRSK1 90 17
BRK 101 12
Aurora B 90 5
Aurora A 106 5
ASK1 105 12
AMPK 105 2
ABL 96 6