Inhibitor | Hypothemycin  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Hypothemycin   C19H22O8 378.37 76958-67-3 6474405 cyclin D1 H. Sonoda (1999) Life Sci. 65 381 A. Zhao (1999) J. Antibiot. 52 1086

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
MKK1
1
 1
TAK1
2
 1
VEGFR1
3
 0
MKK2
9
 0
ERK8 11 0
PKD1 11 1
MKK6 20 15
PRAK 32 3
ERK2 36 3
MNK2 44 6
BRK 48 2
MNK1 55 3
EPH-A2 56 3
ERK1 57 3
IRAK4 57 2
TrkA 67 9
Lck 69 8
HIPK2 72 12
CDK2-Cyclin A 76 2
JNK1 80 3
YES1 81 21
BRSK1 82 9
EPH-B1 84 9
RIPK2 85 6
RSK1 85 4
SYK 85 2
MST4 86 1
Src 86 3
SIK2 88 10
PKC gamma 89 0
PRK2 89 27
MLK3 90 9
CK1 delta 92 22
IKK epsilon 92 9
TESK1 92 12
PIM1 92 5
ULK1 92 15
PKC alpha 92 13
EPH-B3 92 6
TBK1 93 5
PDK1 93 9
MARK4 94 23
CHK1 94 12
AMPK 94 3
CAMKK beta 94 29
SIK3 94 7
PAK6 95 13
CSK 95 24
HIPK1 95 12
PAK2 95 13
MARK3 95 13
DAPK1 96 14
BRSK2 96 3
SmMLCK 96 2
IR 97 4
GCK 97 7
NEK6 98 7
p38 beta MAPK 98 3
PKB beta 99 21
ROCK 2 99 13
MAPKAP-K3 99 9
JNK2 99 3
PIM3 99 6
TSSK1 99 7
PKA 100 18
TAO1 100 5
MARK2 100 4
SRPK1 100 4
MLK1 101 7
TTK 101 5
DYRK1A 101 11
MARK1 101 9
MST2 102 3
MPSK1 102 4
HIPK3 102 4
DYRK2 102 24
MINK1 102 16
MEKK1 102 13
PAK5 103 20
ZAP70 103 10
LKB1 104 2
MELK 104 7
SGK1 104 17
MSK1 104 8
PAK4 104 31
p38 alpha MAPK 105 13
HER4 105 3
PKC zeta 105 5
ABL 105 5
NUAK1 105 16
NEK2a 105 4
CHK2 106 20
WNK1 106 3
S6K1 106 5
PKB alpha 107 3
PHK 107 7
Aurora B 107 1
EPH-A4 107 3
JNK3 107 5
Aurora A 108 5
p38 delta MAPK 108 0
CK1 gamma 2 109 6
MAPKAP-K2 109 22
ASK1 109 4
BTK 109 2
JAK2 109 25
IRAK1 109 43
CDK9-Cyclin T1 111 3
IKK beta 112 10
TTBK1 112 35
CAMK1 112 6
GSK3 beta 113 48
IRR 113 11
STK33 113 5
MST3 114 13
p38 gamma MAPK 114 28
CLK2 114 24
PLK1 114 2
EPH-B2 115 0
EPH-B4 116 35
PIM2 117 29
ULK2 118 35
IGF-1R 119 44
TLK1 120 31
EIF2AK3 121 48
TIE2 122 11
DYRK3 124 6
OSR1 129 30
RSK2 129 19
FGF-R1 132 24
EF2K 133 26
CK2 133 7
DDR2 133 55
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
VEGFR1
5
 2
MKK1 21 5
MKK2 21 1
MKK6 21 12
ERK8 27 0
PKD1 41 1
TAK1 48 5
MNK2 62 16
PRAK 72 17
PKC zeta 78 12
CDK2-Cyclin A 81 9
TTBK1 82 15
YES1 85 18
MPSK1 86 30
HIPK2 86 5
PIM1 87 10
MNK1 87 5
ERK2 87 17
PKC alpha 88 3
ULK1 88 1
PDK1 88 22
MST2 89 9
NEK6 90 12
BRSK1 90 9
TrkA 90 19
CHK2 91 12
Src 91 5
SGK1 91 15
EIF2AK3 92 5
RSK1 92 10
Aurora B 92 4
S6K1 92 9
CHK1 93 14
p38 beta MAPK 93 1
BRSK2 93 12
SIK3 93 7
Lck 93 1
ROCK 2 94 15
PAK2 94 6
PAK6 95 4
TTK 95 13
SRPK1 95 11
ULK2 96 2
CAMK1 96 13
ABL 97 4
IRAK1 97 7
PHK 98 2
EPH-A2 98 5
JNK1 98 8
PIM3 98 6
OSR1 99 4
MARK4 99 3
HIPK1 99 19
NUAK1 99 3
MAPKAP-K3 99 2
IRAK4 99 5
CAMKK beta 99 9
MARK1 99 2
PKA 99 3
MARK2 100 1
BRK 100 24
IKK beta 100 3
IGF-1R 100 14
MELK 100 2
p38 delta MAPK 100 3
HIPK3 100 0
CLK2 100 3
CK1 gamma 2 100 2
PAK4 100 5
PRK2 101 23
TAO1 101 2
JAK2 101 6
MAPKAP-K2 101 4
CK1 delta 101 3
TLK1 101 7
MEKK1 101 13
ZAP70 101 7
TIE2 101 11
JNK3 101 18
MARK3 102 3
MLK3 102 0
ERK1 102 9
RIPK2 102 8
SmMLCK 102 4
EF2K 103 4
ASK1 103 3
Aurora A 103 6
PKB beta 103 7
MST3 104 3
MSK1 104 10
HER4 104 14
CSK 105 9
p38 alpha MAPK 105 6
IKK epsilon 105 4
p38 gamma MAPK 105 18
STK33 105 1
GCK 105 3
AMPK 105 14
DYRK1A 105 4
DYRK2 105 6
GSK3 beta 106 5
MST4 106 9
JNK2 106 6
TESK1 107 6
SIK2 107 2
WNK1 107 1
PLK1 107 7
DAPK1 108 10
IRR 108 3
SYK 108 2
DYRK3 109 3
PKC gamma 109 4
EPH-B1 110 3
TSSK1 110 8
MINK1 111 8
TBK1 112 6
DDR2 113 10
PIM2 114 2
BTK 115 11
PAK5 115 2
EPH-B4 116 14
IR 116 1
CDK9-Cyclin T1 117 17
MLK1 117 4
EPH-B2 118 2
LKB1 120 19
CK2 121 5
EPH-A4 122 2
PKB alpha 124 2
RSK2 125 19
NEK2a 127 7
EPH-B3 130 12
FGF-R1 154 18
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK6 59 0
VEGFR1 65 15
MKK2 74 0
PRAK 74 11
Lck 79 6
ERK8 80 14
PAK4 81 9
DAPK1 82 18
JAK2 84 2
S6K1 87 11
YES1 87 0
PKC alpha 88 15
p38 beta MAPK 88 6
PKD1 89 13
JNK3 89 11
PDK1 89 5
TTBK1 89 4
MARK2 90 7
Aurora B 90 5
BRSK1 90 17
PIM1 90 6
CDK2-Cyclin A 91 6
ULK1 91 2
DDR2 91 11
PKA 91 10
ROCK 2 91 5
EF2K 91 6
MNK2 91 2
MLK3 91 20
CHK2 91 3
GSK3 beta 91 5
PIM3 92 7
PAK6 92 1
MELK 92 2
SGK1 93 2
PIM2 93 3
PRK2 93 8
MAPKAP-K2 93 7
CHK1 93 15
NUAK1 93 5
CLK2 94 2
ULK2 94 3
MPSK1 94 5
WNK1 94 2
TLK1 95 5
CAMK1 96 0
Src 96 15
ERK2 96 9
HIPK2 96 12
ABL 96 6
MST4 96 9
TrkA 97 0
CDK9-Cyclin T1 97 5
IRAK1 97 4
NEK6 97 19
CSK 97 25
MST2 97 6
EPH-A2 97 3
RSK1 97 22
PKC zeta 97 11
EPH-B1 97 5
MARK3 98 5
DYRK1A 98 1
PAK2 99 1
ZAP70 99 20
p38 gamma MAPK 100 1
MNK1 100 6
PHK 100 7
CK1 gamma 2 100 10
MARK1 101 5
TAK1 101 5
p38 delta MAPK 101 6
BRK 101 12
MKK1 101 3
TTK 101 4
CAMKK beta 102 10
SIK3 102 4
PLK1 102 0
PAK5 102 0
NEK2a 103 11
MARK4 103 1
IKK beta 103 3
IGF-1R 103 14
PKC gamma 103 17
RIPK2 104 10
OSR1 104 3
JNK1 104 14
HIPK3 104 1
IRR 104 2
JNK2 105 14
EIF2AK3 105 6
MAPKAP-K3 105 19
PKB beta 105 2
AMPK 105 2
ASK1 105 12
BTK 105 9
SIK2 106 9
MINK1 106 7
Aurora A 106 5
MST3 106 10
TAO1 106 3
MSK1 108 11
SmMLCK 108 7
p38 alpha MAPK 108 18
IKK epsilon 108 9
DYRK2 109 4
EPH-B4 109 1
PKB alpha 109 2
EPH-A4 109 10
TBK1 110 7
SRPK1 111 19
ERK1 111 5
HIPK1 111 9
SYK 112 26
TSSK1 112 9
MEKK1 112 1
IRAK4 112 3
MLK1 112 12
IR 112 18
STK33 113 9
DYRK3 113 6
GCK 114 7
BRSK2 114 11
CK1 delta 116 5
EPH-B3 118 19
FGF-R1 118 7
LKB1 119 10
TESK1 120 36
TIE2 122 14
CK2 123 1
EPH-B2 124 15
RSK2 129 16
HER4 132 24