Inhibitor | BX-517  

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CHK2	0	5
MKK1	7	0
AMPK	7	1
ERK8	7	2
MELK	9	0
MST2	10	2
BRSK2	12	0
VEGFR1	13	2
MARK3	14	3
DYRK2	18	3
FGF-R1	18	2
PHK	18	1
RSK2	19	1
PDK1	20	5
CHK1	21	2
RSK1	24	2
PIM3	25	4
PKD1	27	7
DYRK3	33	1
PRK2	36	5
YES1	42	2
TBK1	43	3
IRR	47	10
GSK3 beta	49	14
HIPK2	51	2
MST4	56	20
SGK1	58	9
CAMKK beta	60	12
Lck	64	4
SmMLCK	65	6
PIM2	65	14
DYRK1A	67	7
PIM1	69	0
IKK epsilon	69	0
Src	71	4
PLK1	72	8
PAK4	76	8
MNK2	78	8
PAK5	78	7
ERK2	79	5
PKB alpha	80	21
MSK1	80	6
PKA	81	13
NEK6	82	7
ERK1	82	15
p38 gamma MAPK	82	1
MNK1	82	1
S6K1	83	0
PKC zeta	83	0
PKB beta	84	22
IKK beta	84	20
ROCK 2	84	4
p38 alpha MAPK	84	11
CDK2-Cyclin A	85	13
NEK2a	86	14
p38 delta MAPK	86	9
CK2	86	0
EPH-A2	87	2
PAK6	88	9
CK1 delta	89	0
SRPK1	93	9
BTK	93	5
IGF-1R	94	2
MAPKAP-K2	94	33
PRAK	94	12
SYK	97	16
EPH-B3	101	2
CSK	102	10
CAMK1	103	17
p38 beta MAPK	105	3
JNK1	106	1
EF2K	106	1
PKC alpha	107	15
IR	110	3
JNK2	118	12

Screen Conc: 0.01µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CHK2	7	7
BRSK2	21	3
AMPK	25	4
MKK1	33	1
MST2	36	2
MELK	47	1
ERK8	49	1
VEGFR1	50	1
PKD1	55	2
DYRK2	59	0
YES1	60	9
PRK2	61	4
FGF-R1	61	4
MARK3	61	2
PDK1	62	3
IGF-1R	63	34
RSK2	65	2
PHK	66	5
CHK1	66	22
PIM3	73	3
IKK beta	74	0
DYRK3	74	4
IRR	75	7
RSK1	75	13
PKB alpha	76	6
Src	79	4
MST4	80	5
PKB beta	82	11
PLK1	82	8
HIPK2	82	3
TBK1	83	5
PAK5	83	24
NEK6	84	6
IKK epsilon	84	7
PKC zeta	84	2
PAK4	85	11
BTK	85	4
SGK1	86	4
p38 alpha MAPK	86	1
MNK2	86	6
MAPKAP-K2	86	1
PKA	87	8
CDK2-Cyclin A	87	3
p38 gamma MAPK	87	2
MSK1	87	0
MNK1	87	2
SmMLCK	89	5
p38 delta MAPK	89	6
ERK1	89	8
ROCK 2	90	3
PRAK	90	4
CAMKK beta	90	5
S6K1	91	10
CK2	91	10
DYRK1A	91	13
NEK2a	92	2
GSK3 beta	92	7
PIM2	92	4
CK1 delta	94	0
Lck	95	15
ERK2	95	8
SRPK1	96	2
CSK	97	9
PIM1	98	2
EPH-B3	99	2
p38 beta MAPK	100	3
EF2K	101	8
EPH-A2	101	15
PAK6	102	0
IR	102	7
SYK	104	5
PKC alpha	113	1
CAMK1	116	15
JNK1	117	18
JNK2	123	9

Screen Conc: 0.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
CHK2	32	7
BRSK2	59	5
AMPK	62	0
PRK2	67	3
IGF-1R	71	59
IKK beta	76	5
YES1	77	8
PKC zeta	78	8
PKB beta	79	7
PAK4	80	7
PKD1	81	2
RSK2	82	4
MST2	83	5
MSK1	83	1
DYRK3	83	3
PAK5	84	13
Src	84	0
ERK8	85	7
PKB alpha	85	1
IKK epsilon	85	6
PLK1	86	18
MELK	86	4
NEK6	86	7
p38 alpha MAPK	87	4
MST4	87	11
MKK1	87	0
ROCK 2	88	10
DYRK2	88	5
p38 gamma MAPK	89	12
HIPK2	89	6
RSK1	89	3
CHK1	89	8
SmMLCK	90	0
IRR	91	1
PKA	92	1
MNK1	92	9
CK2	92	7
NEK2a	92	14
MARK3	93	18
MNK2	93	2
CK1 delta	94	3
PDK1	94	6
VEGFR1	95	7
BTK	95	4
S6K1	95	16
FGF-R1	96	8
PIM3	96	13
p38 delta MAPK	96	10
PIM1	97	12
GSK3 beta	97	21
PIM2	97	23
EPH-A2	97	1
PAK6	97	10
Lck	97	10
PHK	97	10
ERK1	97	3
SRPK1	98	14
MAPKAP-K2	98	11
SGK1	98	16
EF2K	99	29
TBK1	99	4
SYK	100	7
PRAK	100	16
CAMKK beta	101	5
CDK2-Cyclin A	102	3
PKC alpha	102	9
p38 beta MAPK	104	15
CAMK1	104	12
ERK2	108	11
IR	109	20
DYRK1A	110	18
JNK1	114	2
EPH-B3	114	10
CSK	114	32
JNK2	159	63