Inhibitor | KIN 112  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
KIN 112   C32H36N6O4 568.67 Lck Martin M.W. (2006) J.Med.Chem. 49 4981-4991

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
EPH-B1
2
 0
EPH-B2
2
 0
Src
3
 0
BRK
4
 1
EPH-B4
5
 0
MLK1
6
 2
SIK3
7
 1
DDR2
7
 1
SIK2
7
 4
YES1
8
 1
EPH-A2
8
 1
EPH-A4
9
 1
RIPK2 11 3
FGF-R1 11 3
BTK 16 0
HER4 17 2
MLK3 17 0
TESK1 20 10
GCK 22 2
EPH-B3 24 1
VEGFR1 30 8
MINK1 32 1
CHK2 33 3
ABL 35 6
CSK 36 6
PKA 41 0
PAK2 44 0
Lck 48 7
TIE2 50 10
CAMKK beta 53 9
NUAK1 53 3
PHK 54 6
Aurora A 58 7
MEKK1 58 14
TrkA 63 15
PKB beta 64 4
RSK1 64 4
PKD1 65 10
SYK 68 4
JAK2 69 2
MARK1 70 5
TAO1 72 1
MARK3 72 1
HIPK1 72 19
IRAK1 73 10
MAPKAP-K3 74 2
OSR1 75 6
p38 beta MAPK 75 7
RSK2 77 5
MKK1 78 4
MST2 79 4
Aurora B 79 5
MST4 79 4
CK1 delta 82 9
IRAK4 82 2
MSK1 83 9
PKB alpha 84 20
IRR 84 0
ROCK 2 85 11
MST3 85 11
MKK2 85 0
ERK8 85 11
CK1 gamma 2 86 16
TLK1 86 9
PAK5 86 12
BRSK1 87 12
AMPK 87 1
DAPK1 87 5
p38 alpha MAPK 87 1
CHK1 87 2
IKK beta 88 25
JNK2 88 10
MARK2 88 11
HIPK3 89 19
CAMK1 89 6
p38 gamma MAPK 89 8
SRPK1 90 0
SmMLCK 90 11
JNK1 90 2
DYRK3 90 18
NEK2a 90 11
DYRK1A 92 12
JNK3 93 2
S6K1 94 8
EF2K 94 9
NEK6 94 5
SGK1 95 1
PLK1 95 4
MNK2 96 12
CDK9-Cyclin T1 96 9
TTK 96 3
PRK2 96 12
PAK4 96 11
STK33 96 3
GSK3 beta 96 2
PAK6 97 11
BRSK2 97 20
TBK1 97 20
p38 delta MAPK 97 5
PIM3 98 1
MAPKAP-K2 98 20
ERK1 98 8
TSSK1 99 1
IR 99 1
PDK1 100 7
DYRK2 100 2
CLK2 100 6
CK2 100 9
ZAP70 100 5
PIM2 100 58
LKB1 100 2
PKC zeta 101 3
HIPK2 102 1
MPSK1 103 6
WNK1 103 2
TAK1 105 3
ERK2 105 10
EIF2AK3 106 9
TTBK1 107 7
CDK2-Cyclin A 108 6
ASK1 108 19
MKK6 108 14
MELK 109 2
PKC alpha 109 3
PKC gamma 109 1
PIM1 109 4
MNK1 109 7
IKK epsilon 110 15
IGF-1R 112 38
MARK4 112 3
PRAK 122 8
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
DDR2
9
 1
SIK2
10
 5
Src
10
 2
BRK 11 1
EPH-B1 14 11
EPH-A2 16 2
EPH-A4 16 2
YES1 19 2
RIPK2 22 7
MLK1 26 5
SIK3 37 9
Lck 40 7
BTK 40 5
TESK1 52 15
ABL 53 9
EPH-B2 57 8
HER4 57 10
MLK3 62 10
PAK2 65 12
CHK2 65 8
EPH-B3 70 2
GCK 71 1
EPH-B4 71 18
MARK1 73 0
HIPK1 75 9
PKB beta 75 8
PKA 75 8
VEGFR1 77 5
HIPK3 79 3
DAPK1 80 7
PKD1 83 17
MKK2 83 14
IRAK1 83 4
FGF-R1 84 21
CAMKK beta 84 2
CK1 gamma 2 85 1
CK1 delta 85 2
SmMLCK 85 4
MARK3 85 2
OSR1 85 3
TBK1 86 2
PAK6 87 3
NUAK1 88 7
PIM2 88 31
MAPKAP-K3 88 16
TTBK1 88 3
AMPK 88 4
DYRK2 88 9
IRAK4 88 10
GSK3 beta 89 15
TLK1 89 10
PAK5 89 5
PKC zeta 90 2
MST4 90 14
CDK9-Cyclin T1 90 4
MSK1 90 3
MEKK1 90 17
MARK2 90 5
Aurora A 91 8
JAK2 91 6
DYRK3 91 17
ERK8 92 6
CSK 92 18
TAO1 92 7
S6K1 92 13
CAMK1 92 7
JNK2 92 1
PRK2 92 22
MKK1 93 1
p38 delta MAPK 93 18
PLK1 93 1
CK2 93 7
IRR 93 0
NEK6 93 8
PIM3 94 14
MINK1 94 13
SRPK1 94 6
PKB alpha 94 2
CHK1 94 8
ZAP70 95 4
RSK1 96 7
Aurora B 96 11
JNK3 96 3
PIM1 97 9
RSK2 97 2
EIF2AK3 97 2
IGF-1R 97 24
CLK2 97 2
TTK 97 6
SGK1 98 16
p38 beta MAPK 99 9
STK33 99 12
TSSK1 99 25
MNK1 99 6
WNK1 100 1
EF2K 100 10
IR 100 1
TIE2 100 12
PKC alpha 100 3
MELK 100 5
MAPKAP-K2 101 8
DYRK1A 101 10
ASK1 101 11
NEK2a 101 20
MARK4 101 8
PKC gamma 102 5
PDK1 103 5
HIPK2 103 21
ERK2 103 2
JNK1 103 8
PHK 103 3
BRSK1 103 3
MST3 103 8
MKK6 104 3
MNK2 104 3
TrkA 104 3
TAK1 104 4
PAK4 104 4
ROCK 2 104 13
LKB1 106 1
CDK2-Cyclin A 107 0
IKK beta 107 1
MST2 107 10
BRSK2 108 8
IKK epsilon 108 0
p38 gamma MAPK 110 23
MPSK1 110 6
ERK1 113 19
SYK 114 17
p38 alpha MAPK 115 1
PRAK 116 2
Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
DDR2 45 18
Src 45 8
YES1 52 5
Lck 57 6
EPH-A2 57 3
EPH-A4 58 5
SIK2 58 4
EPH-B1 68 4
HIPK1 68 1
HIPK3 77 5
PAK2 79 8
TESK1 80 6
MARK1 82 2
NEK6 82 11
BRK 83 4
MST3 83 30
DAPK1 85 3
PKB beta 85 12
SRPK1 86 9
CK1 delta 86 3
IKK beta 86 4
MNK1 87 2
MLK1 87 17
MLK3 87 27
BTK 87 11
RIPK2 89 11
MARK3 89 3
SIK3 89 3
PRK2 89 5
VEGFR1 89 13
MSK1 90 8
FGF-R1 90 10
CAMKK beta 90 0
IRAK4 90 9
ABL 90 0
EF2K 91 4
DYRK3 91 4
PKA 91 17
PIM2 91 5
JAK2 91 4
TrkA 91 11
IRAK1 92 9
PKC gamma 92 15
JNK1 92 18
BRSK2 93 5
SGK1 93 7
TTBK1 93 2
PLK1 94 1
DYRK2 94 10
TBK1 94 10
CHK2 94 10
TLK1 94 0
RSK1 95 10
HER4 95 7
S6K1 95 6
MAPKAP-K2 95 5
PKD1 95 8
PKB alpha 95 6
ZAP70 95 12
DYRK1A 95 15
MEKK1 96 20
Aurora B 96 7
GSK3 beta 96 5
IRR 96 5
MARK4 96 28
PKC alpha 97 8
CHK1 97 8
SmMLCK 97 5
PDK1 97 5
p38 delta MAPK 97 14
Aurora A 98 2
RSK2 98 5
NUAK1 98 11
NEK2a 98 12
MKK6 98 7
GCK 98 11
TAO1 98 10
IKK epsilon 99 13
CK1 gamma 2 99 16
PKC zeta 99 9
TTK 99 1
CK2 99 6
MKK2 99 27
ROCK 2 99 13
MAPKAP-K3 99 30
AMPK 99 14
MARK2 100 30
MNK2 100 7
EIF2AK3 100 16
MKK1 100 10
HIPK2 100 16
ERK2 100 9
CAMK1 101 11
PAK4 101 5
ERK1 101 1
EPH-B4 101 5
MELK 102 5
PIM3 102 2
MINK1 102 16
JNK2 103 23
JNK3 103 27
p38 gamma MAPK 103 5
PAK5 103 0
SYK 103 4
BRSK1 103 14
PAK6 103 1
ERK8 104 10
OSR1 104 18
EPH-B2 104 1
MST4 105 10
PIM1 106 2
ASK1 106 20
CDK9-Cyclin T1 106 4
WNK1 107 13
PHK 108 22
MPSK1 109 10
TSSK1 110 12
CLK2 110 1
LKB1 110 7
IR 111 2
MST2 113 29
p38 beta MAPK 113 10
STK33 113 28
CDK2-Cyclin A 115 14
CSK 117 15
p38 alpha MAPK 118 9
EPH-B3 121 8
TAK1 122 11
TIE2 125 3
IGF-1R 126 0
PRAK 138 28