Inhibitor | Amgen TBK 1 inhibitor (Compound II)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ZAP70 22 4
YES1
7
 2
VEGFR1
2
 0
TTK 64 4
TTBK1 102 8
TSSK1
5
 0
TrkA 11 1
TLK1 39 0
TIE2 11 4
TESK1 24 5
TBK1
8
 1
TAO1 74 8
TAK1 19 12
SYK 13 0
STK33 23 3
SRPK1 87 1
Src
3
 0
SmMLCK 72 11
SGK1 61 1
S6K1 28 3
RSK2
9
 1
RSK1
7
 0
ROCK 2 25 5
RIPK2 14 1
PRK2 27 4
PRAK 85 1
PLK1 91 7
PKD1 48 6
PKC zeta 78 5
PKC gamma 71 19
PKC alpha 56 9
PKB beta 77 0
PKB alpha 89 7
PKA 26 5
PIM3 63 4
PIM2 106 6
PIM1 62 0
PHK 12 1
PDK1 36 3
PAK6 24 2
PAK5 18 0
PAK4
9
 0
PAK2 14 1
p38 gamma MAPK 95 1
p38 delta MAPK 68 2
p38 beta MAPK 95 14
p38 alpha MAPK 85 12
OSR1 71 4
NUAK1 13 1
NEK6 59 5
NEK2a
3
 1
MST4 67 2
MST2 61 39
MSK1 34 4
MPSK1 42 5
MNK2 17 5
MNK1 17 0
MLK3
8
 0
MLK1
6
 0
MKK6 75 4
MKK2 28 4
MKK1 13 2
MINK1 57 5
MELK 27 4
MEKK1 92 9
MARK4 24 5
MARK3 16 1
MARK2 28 9
MARK1 31 14
MAPKAP-K3 81 12
MAPKAP-K2 108 5
LKB1 73 2
Lck
4
 0
JNK3 39 0
JNK2 33 1
JNK1 38 0
JAK2
3
 1
IRR 35 3
IRAK4 20 1
IRAK1
5
 2
IR 21 7
IKK epsilon 18 4
IKK beta 55 6
IGF-1R
6
 1
HIPK3 19 0
HIPK2
10
 1
HIPK1 17 4
HER4 17 1
GSK3 beta
6
 1
GCK 56 22
FGF-R1
8
 4
ERK8
4
 1
ERK2 57 5
ERK1 82 0
EPH-B4
3
 0
EPH-B3 16 4
EPH-B2
6
 2
EPH-B1
3
 1
EPH-A4
5
 1
EPH-A2 32 26
EIF2AK3 31 0
EF2K 91 5
DYRK3
10
 2
DYRK2 16 2
DYRK1A 12 1
DAPK1 15 1
CSK 38 15
CLK2 11 4
CK2
6
 5
CK1 delta 69 8
CHK2 12 2
CHK1 20 1
CDK2-Cyclin A
7
 1
CAMKK beta 28 1
CAMK1 26 2
BTK 14 1
BRSK2 35 7
BRSK1 17 1
BRK
6
 1
Aurora B 11 3
Aurora A
3
 1
ASK1 77 5
AMPK 22 0
ABL
7
 3
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ZAP70 54 1
YES1 16 9
VEGFR1
5
 1
TTK 81 1
TTBK1 104 11
TSSK1 31 7
TrkA 32 4
TLK1 79 1
TIE2 60 4
TESK1 59 10
TBK1 14 0
TAO1 95 7
TAK1 14 3
SYK 58 7
STK33 30 2
SRPK1 104 4
Src
7
 1
SmMLCK 100 6
SGK1 107 10
S6K1 70 15
RSK2 38 1
RSK1 62 44
ROCK 2 49 5
RIPK2 28 5
PRK2 57 3
PRAK 98 12
PLK1 90 11
PKD1 100 0
PKC zeta 94 21
PKC gamma 117 7
PKC alpha 95 15
PKB beta 88 17
PKB alpha 99 12
PKA 78 11
PIM3 91 6
PIM2 108 16
PIM1 96 17
PHK 56 1
PDK1 96 4
PAK6 62 8
PAK5 53 0
PAK4 29 1
PAK2 50 14
p38 gamma MAPK 113 16
p38 delta MAPK 93 21
p38 beta MAPK 103 2
p38 alpha MAPK 98 4
OSR1 101 14
NUAK1 16 2
NEK6 89 2
NEK2a 22 2
MST4 90 18
MST2 78 5
MSK1 76 8
MPSK1 101 1
MNK2 67 9
MNK1 59 5
MLK3 15 5
MLK1
7
 1
MKK6 99 5
MKK2 55 7
MKK1 40 8
MINK1 104 14
MELK 37 0
MEKK1 103 7
MARK4 92 24
MARK3 41 9
MARK2 67 4
MARK1 63 6
MAPKAP-K3 97 3
MAPKAP-K2 105 25
LKB1 119 14
Lck
10
 2
JNK3 65 13
JNK2 85 21
JNK1 89 13
JAK2
4
 0
IRR 78 9
IRAK4 64 11
IRAK1 19 3
IR 79 4
IKK epsilon 28 6
IKK beta 86 8
IGF-1R 104 19
HIPK3 69 12
HIPK2 31 11
HIPK1 44 13
HER4 60 4
GSK3 beta 37 6
GCK 29 9
FGF-R1 20 1
ERK8 22 6
ERK2 84 13
ERK1 111 12
EPH-B4 69 13
EPH-B3 86 16
EPH-B2 23 11
EPH-B1
8
 0
EPH-A4 14 0
EPH-A2 28 12
EIF2AK3 90 20
EF2K 100 13
DYRK3 75 30
DYRK2 50 5
DYRK1A 57 3
DAPK1 51 5
CSK 65 5
CLK2 30 10
CK2 33 2
CK1 delta 95 1
CHK2 48 0
CHK1 72 0
CDK2-Cyclin A 34 2
CAMKK beta 58 4
CAMK1 67 2
BTK 22 2
BRSK2 84 5
BRSK1 74 2
BRK 46 4
Aurora B 36 1
Aurora A 18 3
ASK1 99 3
AMPK 25 4
ABL 31 2