Inhibitor | GW843682X (GSK-PLK1 Compound 2)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
GW843682X (GSK-PLK1 Compound 2)   C22H18F3N3O4S 477.46 660868-91-7 9826308 PLK1 Emmitte K.A. (2009) Bioorganic and Medicinal Chemistry Letters 19 1018-1021

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 102 6
AMPK 88 4
ASK1 97 8
Aurora A 98 5
Aurora B 57 1
BRK 122 2
BRSK1 67 2
BRSK2 71 3
BTK 91 2
CAMK1 106 2
CAMKK beta 79 6
CDK2-Cyclin A 96 6
CDK9-Cyclin T1 97 1
CHK1 110 2
CHK2 85 12
CK1 delta 80 1
CK1 gamma 2 79 3
CK2 105 8
CLK2 92 12
CSK 85 4
DAPK1 104 2
DDR2 105 1
DYRK1A 99 1
DYRK2 89 0
DYRK3 99 5
EF2K 99 6
EIF2AK3 98 13
EPH-A2 106 13
EPH-A4 88 4
EPH-B1 90 6
EPH-B2 123 15
EPH-B3 100 3
EPH-B4 107 4
ERK1 96 9
ERK2 95 8
ERK8 77 3
FGF-R1 91 6
GCK 94 4
GSK3 beta 85 0
HER4 101 11
HIPK1 111 10
HIPK2 108 2
HIPK3 106 4
IGF-1R 101 8
IKK beta 92 3
IKK epsilon 100 2
IR 87 2
IRAK1 110 3
IRAK4 89 6
IRR 104 6
JAK2 102 4
JNK1 92 9
JNK2 99 7
JNK3 104 2
Lck 103 3
LKB1 108 5
MAPKAP-K2 85 7
MAPKAP-K3 88 5
MARK1 85 3
MARK2 102 8
MARK3 85 1
MARK4 115 3
MEKK1 65 13
MELK 104 7
MINK1 76 8
MKK1 97 6
MKK2 89 5
MKK6 96 3
MLK1 85 1
MLK3 81 2
MNK1 106 3
MNK2 107 10
MPSK1 105 11
MSK1 96 9
MST2 52 6
MST3 99 10
MST4 84 3
NEK2a 70 12
NEK6 98 4
NUAK1 44 4
OSR1 101 5
p38 alpha MAPK 104 11
p38 beta MAPK 100 13
p38 delta MAPK 104 4
p38 gamma MAPK 107 7
PAK2 93 7
PAK4 96 8
PAK5 100 5
PAK6 110 0
PDK1 102 5
PHK 92 5
PIM1 93 7
PIM2 102 9
PIM3 96 15
PKA 101 3
PKB alpha 98 2
PKB beta 93 3
PKC alpha 116 3
PKC gamma 107 13
PKC zeta 110 10
PKD1 97 8
PLK1
7
 2
PRAK 90 1
PRK2 66 7
RIPK2 77 5
ROCK 2 96 6
RSK1 96 2
RSK2 104 15
S6K1 96 8
SGK1 110 9
SIK2 83 2
SIK3 87 5
SmMLCK 87 5
Src 91 4
SRPK1 89 2
STK33 96 4
SYK 125 0
TAK1 97 8
TAO1 89 15
TBK1 95 8
TESK1 102 6
TIE2 90 6
TLK1 108 13
TrkA 94 10
TSSK1 98 0
TTBK1 98 10
TTK 105 8
VEGFR1 75 10
WNK1 99 1
YES1 109 7
ZAP70 93 11
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 86 6
AMPK 62 7
ASK1 74 9
Aurora A 97 5
Aurora B 16 2
BRK 101 5
BRSK1 18 1
BRSK2 23 1
BTK 62 1
CAMK1 93 0
CAMKK beta 49 0
CDK2-Cyclin A 77 7
CDK9-Cyclin T1 93 4
CHK1 79 12
CHK2 46 2
CK1 delta 79 10
CK1 gamma 2 85 1
CK2 96 3
CLK2 50 2
CSK 70 6
DAPK1 68 2
DDR2 96 0
DYRK1A 76 3
DYRK2 54 3
DYRK3 56 6
EF2K 94 1
EIF2AK3 91 6
EPH-A2 84 2
EPH-A4 69 7
EPH-B1 86 4
EPH-B2 96 6
EPH-B3 100 3
EPH-B4 104 3
ERK1 86 5
ERK2 75 7
ERK8 26 9
FGF-R1 32 1
GCK 48 3
GSK3 beta 59 1
HER4 87 0
HIPK1 95 2
HIPK2 81 2
HIPK3 93 8
IGF-1R 118 3
IKK beta 87 7
IKK epsilon 77 6
IR 81 9
IRAK1 96 15
IRAK4 64 10
IRR 76 15
JAK2 75 2
JNK1 82 9
JNK2 92 11
JNK3 83 2
Lck 54 3
LKB1 104 6
MAPKAP-K2 76 2
MAPKAP-K3 74 7
MARK1 71 0
MARK2 97 12
MARK3 49 7
MARK4 73 12
MEKK1 29 3
MELK 74 0
MINK1 45 4
MKK1 74 6
MKK2 81 11
MKK6 77 2
MLK1 43 2
MLK3 42 4
MNK1 99 1
MNK2 90 2
MPSK1 94 1
MSK1 89 1
MST2 22 3
MST3 86 7
MST4 159 14
NEK2a 23 3
NEK6 86 5
NUAK1
9
 2
OSR1 100 7
p38 alpha MAPK 88 5
p38 beta MAPK 99 4
p38 delta MAPK 104 0
p38 gamma MAPK 102 3
PAK2 87 2
PAK4 96 1
PAK5 77 1
PAK6 86 2
PDK1 84 5
PHK 90 8
PIM1 70 5
PIM2 98 12
PIM3 38 14
PKA 101 4
PKB alpha 82 4
PKB beta 86 3
PKC alpha 106 4
PKC gamma 111 0
PKC zeta 91 11
PKD1 82 11
PLK1
5
 2
PRAK 95 6
PRK2 22 2
RIPK2 29 0
ROCK 2 93 1
RSK1 53 11
RSK2 57 9
S6K1 81 2
SGK1 103 10
SIK2 27 0
SIK3 47 5
SmMLCK 57 1
Src 61 6
SRPK1 76 4
STK33 69 13
SYK 105 1
TAK1 70 1
TAO1 75 9
TBK1 53 9
TESK1 88 1
TIE2 56 10
TLK1 109 4
TrkA 72 7
TSSK1 70 4
TTBK1 95 3
TTK 82 6
VEGFR1 33 2
WNK1 95 2
YES1 69 7
ZAP70 100 6
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 58 7
AMPK 48 11
ASK1 39 8
Aurora A 60 11
Aurora B
3
 1
BRK 90 10
BRSK1
7
 1
BRSK2 18 3
BTK 38 2
CAMK1 89 2
CAMKK beta 61 46
CDK2-Cyclin A 56 8
CDK9-Cyclin T1 67 3
CHK1 77 4
CHK2 30 14
CK1 delta 73 8
CK1 gamma 2 91 1
CK2 87 12
CLK2 32 3
CSK 42 1
DAPK1 31 3
DDR2 77 12
DYRK1A 84 1
DYRK2 37 4
DYRK3 40 15
EF2K 97 1
EIF2AK3 96 11
EPH-A2 55 0
EPH-A4 55 2
EPH-B1 53 1
EPH-B2 82 1
EPH-B3 100 3
EPH-B4 89 12
ERK1 91 1
ERK2 93 2
ERK8 13 4
FGF-R1 17 1
GCK 24 2
GSK3 beta 41 2
HER4 77 12
HIPK1 98 4
HIPK2 54 7
HIPK3 84 7
IGF-1R 90 7
IKK beta 81 1
IKK epsilon 86 15
IR 68 1
IRAK1 55 14
IRAK4 49 7
IRR 77 18
JAK2 58 6
JNK1 69 6
JNK2 82 11
JNK3 65 12
Lck 24 3
LKB1 70 12
MAPKAP-K2 66 5
MAPKAP-K3 54 4
MARK1 71 27
MARK2 73 5
MARK3 36 11
MARK4 61 16
MEKK1 17 2
MELK 50 0
MINK1 53 28
MKK1 66 9
MKK2 74 6
MKK6 78 0
MLK1 26 10
MLK3 20 2
MNK1 84 15
MNK2 86 10
MPSK1 87 15
MSK1 51 5
MST2 12 1
MST3 138 86
MST4 278 15
NEK2a 18 2
NEK6 64 2
NUAK1
7
 3
OSR1 72 9
p38 alpha MAPK 82 1
p38 beta MAPK 79 0
p38 delta MAPK 105 4
p38 gamma MAPK 90 2
PAK2 124 20
PAK4 73 1
PAK5 78 6
PAK6 75 3
PDK1 66 7
PHK 73 1
PIM1 41 9
PIM2 96 11
PIM3 27 3
PKA 92 8
PKB alpha 94 2
PKB beta 54 2
PKC alpha 100 1
PKC gamma 87 5
PKC zeta 91 4
PKD1 74 21
PLK1
4
 2
PRAK 78 9
PRK2 12 2
RIPK2 14 2
ROCK 2 64 5
RSK1 54 40
RSK2 42 2
S6K1 75 20
SGK1 80 8
SIK2 14 1
SIK3 26 1
SmMLCK 32 3
Src 48 4
SRPK1 73 9
STK33 59 14
SYK 71 1
TAK1 42 6
TAO1 72 4
TBK1 63 13
TESK1 69 7
TIE2 26 2
TLK1 97 4
TrkA 45 4
TSSK1 53 4
TTBK1 87 12
TTK 80 10
VEGFR1 17 2
WNK1 74 6
YES1 50 6
ZAP70 89 13