Inhibitor | PD 0325901-Cl (CI-1055-Racemic mix of isomers)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PD 0325901-Cl (CI-1055-Racemic mix of isomers)   C16H14O4N2F2ClI 498.65 391210-10-9 MEK1

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
MKK1
3
 1
JAK2
8
 1
MKK2 23 0
VEGFR1 42 13
PIM3 65 5
MKK6 67 6
MARK1 71 4
PIM1 71 8
Src 72 1
MST2 75 16
PAK4 77 14
LKB1 77 3
EPH-B2 77 2
MAPKAP-K3 77 19
SYK 77 9
Aurora B 78 0
TrkA 78 14
IRAK1 79 2
ERK2 79 6
YES1 79 1
PRK2 79 13
PAK2 80 7
S6K1 80 17
EPH-B3 82 9
HER4 82 6
DYRK3 83 19
RIPK2 84 8
CAMK1 84 2
DYRK1A 85 8
MLK1 85 10
HIPK1 85 9
PAK5 86 3
MPSK1 86 16
EPH-B4 86 3
SmMLCK 86 12
SRPK1 86 7
PKC alpha 86 8
OSR1 87 5
IRR 87 20
PKD1 87 8
TIE2 87 5
MARK3 88 5
CSK 88 13
RSK2 89 3
IKK beta 89 9
MLK3 89 4
GSK3 beta 89 3
STK33 90 4
MNK2 90 5
PKB beta 90 13
PHK 90 5
JNK3 90 26
EIF2AK3 90 28
CLK2 91 4
IRAK4 91 11
GCK 91 1
PKC zeta 91 0
EPH-B1 92 6
JNK2 92 8
EF2K 92 1
TAK1 92 6
PLK1 93 1
PIM2 93 8
JNK1 93 2
MEKK1 93 7
CHK2 93 10
NEK2a 94 6
MST4 94 3
MNK1 95 15
NUAK1 95 4
MSK1 96 6
p38 gamma MAPK 96 3
p38 delta MAPK 97 7
IR 97 28
BTK 97 9
p38 alpha MAPK 97 0
CK1 delta 97 2
CDK2-Cyclin A 97 2
ERK8 98 19
RSK1 98 3
TTK 98 2
IGF-1R 98 8
DAPK1 98 17
ZAP70 98 0
CK2 98 13
PDK1 99 3
PKB alpha 99 4
TBK1 99 3
FGF-R1 99 37
TAO1 99 25
EPH-A4 100 4
TLK1 100 9
PRAK 100 13
PKC gamma 100 0
HIPK3 101 6
MARK2 101 3
ERK1 101 18
BRSK1 101 14
MAPKAP-K2 102 10
NEK6 103 15
PAK6 103 2
IKK epsilon 103 11
CAMKK beta 103 1
PKA 103 3
ROCK 2 103 16
Aurora A 104 12
Lck 104 11
EPH-A2 105 7
BRSK2 105 1
MELK 106 4
HIPK2 106 1
ABL 107 11
MARK4 108 10
BRK 110 8
DYRK2 111 5
SGK1 111 18
ASK1 112 14
CHK1 119 2
AMPK 120 4
MINK1 127 5
p38 beta MAPK 133 18
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
JAK2
5
 1
MKK1 36 14
MKK2 55 9
PRK2 70 1
SGK1 71 4
MST2 71 8
SYK 73 46
MARK3 73 9
YES1 76 1
IGF-1R 76 1
ZAP70 77 14
IRAK4 77 5
MARK1 77 1
IKK beta 78 3
TrkA 79 6
GCK 79 14
p38 gamma MAPK 80 3
LKB1 80 14
IRAK1 81 1
ERK2 83 8
MLK3 83 18
JNK3 83 16
MLK1 84 0
IRR 84 0
EF2K 84 7
p38 delta MAPK 84 3
RIPK2 86 7
HER4 86 4
JNK1 87 1
OSR1 87 22
MPSK1 87 10
MEKK1 88 5
JNK2 88 0
GSK3 beta 89 9
PKC zeta 89 2
MNK2 89 7
CSK 89 16
MKK6 90 2
HIPK3 90 2
PIM2 91 13
TAK1 91 14
DYRK1A 91 3
PKD1 91 4
TAO1 92 25
STK33 92 10
IR 93 28
PKC alpha 93 12
PRAK 93 8
Lck 93 8
PHK 94 2
PIM3 94 0
S6K1 94 4
PKA 94 7
CLK2 94 5
MAPKAP-K3 94 3
SRPK1 95 0
CDK2-Cyclin A 95 7
PAK2 95 3
TLK1 95 10
ERK8 95 8
CK1 delta 96 5
HIPK1 96 5
DAPK1 97 6
PLK1 97 1
EPH-A4 97 5
PKB beta 97 4
BRSK1 98 11
VEGFR1 98 8
NEK2a 98 4
PAK4 98 4
MSK1 98 0
PAK6 98 21
RSK2 98 15
EPH-B4 98 5
Aurora B 99 2
PKB alpha 99 21
ERK1 100 7
EPH-B2 100 20
PDK1 100 2
ABL 101 10
p38 beta MAPK 101 3
NEK6 101 11
MARK2 101 10
SmMLCK 102 23
BTK 102 9
ROCK 2 102 1
ASK1 102 13
HIPK2 102 7
p38 alpha MAPK 102 7
PAK5 102 13
IKK epsilon 102 9
PIM1 102 6
EIF2AK3 103 25
Aurora A 103 9
CHK2 104 2
MAPKAP-K2 104 12
TTK 105 3
TIE2 106 7
MNK1 106 5
CAMK1 106 1
DYRK2 107 13
DYRK3 107 0
EPH-B1 107 6
MST4 107 4
BRSK2 108 9
NUAK1 108 14
CAMKK beta 108 0
MELK 109 11
PKC gamma 110 13
FGF-R1 110 28
CK2 111 8
AMPK 111 18
TBK1 111 5
EPH-A2 112 11
EPH-B3 113 17
CHK1 116 17
MARK4 119 12
MINK1 119 10
RSK1 122 7
Src 124 4
BRK 126 13