Inhibitor | PCI-32765 (Ibrutinib)  

Screen Conc: 10.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
VEGFR1	2	1
RIPK2	2	0
CSK	3	0
HER4	5	1
Src	6	4
BRK	8	5
Lck	9	3
TIE2	9	1
Aurora A	10	1
EPH-B2	11	1
TrkA	13	7
Aurora B	13	1
YES1	13	0
FGF-R1	15	2
NUAK1	26	13
MLK1	27	18
MST4	27	6
MLK3	28	5
EIF2AK3	28	2
IRR	29	5
PKD1	30	6
IR	31	11
CAMK1	33	8
CHK2	35	9
NEK2a	35	2
TESK1	38	8
GCK	38	0
ABL	39	2
EPH-B4	39	0
MST2	41	9
BTK	42	4
PAK4	42	6
SmMLCK	44	6
EPH-A4	45	1
RSK1	46	5
BRSK1	49	11
PAK5	50	3
EPH-B3	51	2
SYK	52	6
PAK2	55	4
MSK1	55	6
MELK	56	18
MKK1	56	3
MEKK1	56	4
MINK1	57	3
BRSK2	61	12
MKK6	61	12
IGF-1R	63	19
MKK2	63	2
EPH-A2	64	5
TAK1	66	4
IKK epsilon	66	15
S6K1	66	1
HIPK2	66	2
MNK2	67	4
RSK2	68	7
TSSK1	68	5
p38 beta MAPK	68	4
DYRK3	68	5
ROCK 2	69	6
CLK2	71	10
PKB beta	71	4
ERK8	74	1
GSK3 beta	75	9
HIPK1	75	14
MAPKAP-K3	75	20
JNK1	75	1
MARK3	76	14
PLK1	76	3
CHK1	77	0
PKB alpha	78	1
AMPK	78	1
DYRK2	79	2
CAMKK beta	80	3
MARK4	80	6
p38 delta MAPK	80	3
TTBK1	81	11
PKC zeta	81	3
PIM1	81	3
PAK6	82	3
TTK	82	9
MARK2	82	7
OSR1	82	9
JAK2	83	13
PRAK	83	11
SGK1	84	1
MNK1	84	6
ERK1	84	7
CDK2-Cyclin A	84	6
TAO1	84	1
DAPK1	84	5
JNK3	86	2
EPH-B1	86	2
IRAK4	86	3
DYRK1A	87	1
p38 gamma MAPK	88	10
MARK1	88	11
PIM3	88	4
IKK beta	90	12
EF2K	90	6
TBK1	90	7
MAPKAP-K2	90	1
ERK2	90	12
PRK2	90	2
PHK	92	7
NEK6	93	12
TLK1	96	6
PKA	97	11
PIM2	97	15
IRAK1	98	32
SRPK1	99	0
PKC gamma	99	5
PKC alpha	100	12
LKB1	100	0
p38 alpha MAPK	101	8
ZAP70	101	10
PDK1	102	14
MPSK1	104	7
HIPK3	110	8
CK2	111	10
ASK1	111	6
STK33	113	101
CK1 delta	115	15
JNK2	123	29

Screen Conc: 1.00µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
BRK	4	1
RIPK2	5	0
VEGFR1	7	1
HER4	8	1
Src	13	1
Lck	14	2
CSK	15	13
YES1	16	0
FGF-R1	24	1
TIE2	34	4
TrkA	46	1
BTK	55	1
Aurora A	57	2
Aurora B	61	7
EPH-B2	65	0
MST2	65	2
MLK3	65	5
PKD1	69	7
TESK1	71	14
PAK2	72	4
MST4	73	4
EPH-B4	74	0
MKK1	76	3
GCK	77	6
CHK2	77	6
ABL	80	1
BRSK1	80	28
EIF2AK3	81	5
MNK2	82	21
NUAK1	82	8
STK33	84	10
PAK4	85	9
DYRK3	86	14
S6K1	86	8
HIPK1	87	2
MLK1	89	5
EPH-B1	90	9
SmMLCK	90	1
HIPK2	91	14
MINK1	91	4
BRSK2	91	2
EPH-A4	92	13
PKB beta	93	7
IGF-1R	93	1
ERK1	93	21
CHK1	93	9
MKK2	94	6
MARK3	94	3
PLK1	95	3
CLK2	95	9
MAPKAP-K2	95	9
IKK epsilon	95	19
PIM1	95	1
DAPK1	95	15
GSK3 beta	95	6
OSR1	96	4
EPH-B3	96	5
JNK3	96	5
PIM3	96	12
PKB alpha	97	1
PAK5	97	2
PAK6	97	3
MKK6	97	1
EPH-A2	98	9
ERK8	98	6
JNK1	98	7
PKC zeta	98	1
CDK2-Cyclin A	99	10
TLK1	99	2
NEK6	99	9
CAMK1	99	12
IR	99	10
ERK2	99	0
TTBK1	100	9
PIM2	100	17
PRK2	100	9
SYK	100	4
MSK1	101	6
RSK1	101	6
TTK	101	3
AMPK	101	7
PKA	101	0
IRR	101	0
JNK2	101	3
IRAK4	102	9
MARK2	102	6
EF2K	102	21
MARK1	103	12
JAK2	103	2
MEKK1	103	17
p38 alpha MAPK	103	3
p38 beta MAPK	103	8
p38 delta MAPK	104	14
PHK	104	10
PKC gamma	104	14
DYRK1A	105	8
DYRK2	105	9
MELK	105	37
TAK1	106	13
RSK2	106	19
PKC alpha	106	21
NEK2a	107	12
PRAK	107	6
SGK1	107	0
IKK beta	107	6
ZAP70	107	5
TSSK1	108	4
MAPKAP-K3	109	0
CAMKK beta	109	5
CK1 delta	111	8
ROCK 2	111	3
p38 gamma MAPK	112	1
TBK1	113	4
MARK4	114	5
CK2	115	7
MNK1	115	14
SRPK1	115	8
IRAK1	115	3
MPSK1	117	9
TAO1	119	1
HIPK3	123	4
PDK1	124	14
ASK1	128	1
LKB1	134	43

Screen Conc: 0.10µM

Kinase	% Activity Remaining Sort descending	Standard Deviation
HER4	7	0
BRK	10	3
YES1	20	0
RIPK2	21	1
Lck	22	1
CSK	25	6
Src	37	4
VEGFR1	40	3
FGF-R1	52	8
BTK	55	3
TrkA	64	9
PKD1	64	16
TESK1	69	9
MELK	69	5
TIE2	71	10
EPH-B1	72	4
HIPK1	75	4
CHK1	76	9
NEK6	76	11
IR	77	3
TTBK1	78	5
SmMLCK	79	1
PKB alpha	79	10
CAMK1	80	13
PKB beta	80	4
BRSK1	81	23
MKK6	82	0
DYRK2	83	1
ERK1	83	8
EPH-B4	83	9
JNK3	84	7
PKC gamma	85	0
ERK8	85	3
MKK1	85	2
CAMKK beta	86	5
PAK2	87	1
ABL	87	13
MLK3	87	0
MARK2	88	11
p38 delta MAPK	88	9
PLK1	88	13
MST2	88	3
MAPKAP-K2	88	5
AMPK	88	4
EF2K	88	0
PKA	89	1
JNK2	89	9
p38 gamma MAPK	89	9
CDK2-Cyclin A	89	5
JAK2	90	2
MINK1	90	0
SYK	90	7
PKC zeta	90	10
HIPK2	91	11
EPH-A2	91	10
MNK1	91	17
CHK2	92	8
Aurora A	92	0
S6K1	93	4
ROCK 2	93	3
DYRK3	93	8
PAK4	93	10
NEK2a	93	6
PAK5	93	13
ZAP70	93	16
PDK1	93	8
ERK2	94	7
IRR	94	3
PIM3	94	4
p38 beta MAPK	94	20
RSK1	94	12
MSK1	94	6
IKK beta	94	4
MKK2	94	1
SGK1	95	7
IGF-1R	95	0
DAPK1	95	4
TTK	95	1
PAK6	95	3
OSR1	96	1
Aurora B	96	13
TLK1	96	12
CLK2	96	15
EPH-A4	97	20
STK33	97	2
MARK3	98	11
GCK	98	5
JNK1	98	6
PIM1	98	2
CK1 delta	98	5
PIM2	99	1
PKC alpha	99	8
p38 alpha MAPK	99	1
NUAK1	99	10
EPH-B3	99	3
MPSK1	99	2
BRSK2	100	9
HIPK3	100	12
SRPK1	100	9
IKK epsilon	100	4
MST4	100	10
PRAK	101	8
MARK1	101	14
TBK1	102	3
EPH-B2	102	10
TAK1	102	10
IRAK4	103	12
ASK1	103	1
RSK2	103	6
GSK3 beta	104	17
CK2	104	15
MLK1	104	7
TSSK1	105	2
MEKK1	106	6
MNK2	106	9
LKB1	106	5
IRAK1	108	7
PRK2	109	9
MAPKAP-K3	109	5
EIF2AK3	110	13
MARK4	111	1
DYRK1A	112	8
TAO1	113	5
PHK	116	34